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Improved HIV-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture

A bispecific antibody and antibody technology, applied in the direction of antibodies, specific peptides, antiviral agents, etc., can solve problems such as the accessibility of unknown HIV envelope epitopes

Active Publication Date: 2016-11-09
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also unknown whether sufficient epitope accessibility exists on the HIV envelope

Method used

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  • Improved HIV-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture
  • Improved HIV-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture
  • Improved HIV-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture

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Embodiment Construction

[0050] Embodiments of the invention provide inhibition of HIV. In various implementations, bispecific antibodies are formed, each comprising heavy and light chain components from two different parental antibodies. One parent antibody specifically binds HIV, eg the HIV envelope protein Env. The other parent antibody specifically binds cell membrane proteins such as CD4 and CCR5. In a bispecific antibody, the heavy and light chains of each antibody from two parental antibodies are combined, thereby providing an antibody in which fragment antigen-binding 1 (Fab1) and Fab2 have different binding specificities. In certain embodiments, the bispecific antibody is such as figure 1 Antibodies in CrossMab format as indicated. In the CrossMab format, one heavy chain includes a "knob" structure and the other includes a corresponding "hole" structure, and the positions of the constant domains (i.e., CL and CH1) from one parental antibody switch, together ensuring the correct pairing of...

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Abstract

In various embodiments, the present invention relates generally to using bispecific antibodies in the prevention and treatment of HIV.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to, and the benefit of, U.S. Provisional Patent Application No. 61 / 910,685, entitled IMPROVED HIV-1-NEUTRALIZING ANTIBODY POTENCY AND BREADTH VIA CELL RECEPTORANCHORING USING BISPECIFIC ANTIBODIES WITH NATIVE ARCHITECTURE, filed December 2, 2013, and Incorporated herein by reference in its entirety. field of invention [0003] In various embodiments, the invention generally relates to the use of bispecific antibodies for the prevention and treatment of HIV. Background technique [0004] Passive immunization with antibodies (Ab) is a well-established method for the prevention and treatment of infectious diseases. This method may involve preparing human immunoglobulins from a donor who has recovered from an infectious disease and using such preparations containing Ab specific for the infecting organism to protect recipients against the same disease. Alternatively, therapeutic antibodies...

Claims

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Application Information

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IPC IPC(8): A61P31/18A61K39/42C07K16/46
CPCC07K2317/24C07K2317/94C07K16/1063C07K16/2812C07K16/2866C07K2317/76C07K2317/31A61P31/18A61K2039/505C07K2317/51C07K2317/515
Inventor 何大一黄耀星于健
Owner THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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