Nano bone repair material preparation method

A bone repair and nano technology, applied in the field of preparation of nano bone repair materials, can solve the problems of low mechanical strength, poor biocompatibility, difficult curing, etc., and achieve the effects of simple preparation steps, improved mechanical properties, and improved bone repair ability.

Inactive Publication Date: 2016-11-16
梅庆波
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention: Aiming at the drawbacks that currently used nano-bone repair materials need to be bonded to human bones for a long time, their biocompatibility is poor, their mechanical strength is low, and they are difficult to solidify when encountering body fluids and blood. The bovine bones are harvested, the bone marrow is removed, mixed with clean water and boiled, and then hydroxyapatite, nano-scale calcium carbonate powder and nano-scale calcium sulfate powder are added in sequence. The slurry is mixed with fresh water in proportion to feed the shells with a culture solution, and then the slurry is added to the culture solution every day to cultivate it. After the cultivation, the shells are taken out and the pearls are taken out from the shells, which are freeze-dried, ground, Method for preparing nano-bone repair material by vacuum drying, so as to achieve the purpose of improving its biocompatibility and mechanical strength

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] First weigh 2kg of beef bones, remove the bone marrow from the bones, rinse them with water once, then put them into a round-bottomed pot, and add water to the round-bottomed pot at the same time, the amount of water added should cover the beef bones by 3cm , and then heated up to 100°C at a rate of 10°C / min, and then cooked; then when the above-mentioned cooking until the color of beef bone soup was off-white, weighed 10g of hydroxyapatite, put it into a mill for grinding, and milled The obtained powder is put into the beef bone soup and boiled, and when the color of the beef bone soup is milky white, 8g of nano-scale calcium carbonate powder is added thereto, the temperature is lowered to 60°C, and the steaming is carried out; When it is milky white, add 4g of nano-scale calcium sulfate powder to it, lower the temperature to 40°C, cook until the beef bone broth boils, then add 10mL of γ-aminopropyltriethoxysilane to it, stir and mix at 300r / min Evenly, after 40 minute...

example 2

[0020] First weigh 3kg of beef bones, remove the bone marrow from the bones, wash them with water for 2 times, then put them into a round bottom pot, and add water to the round bottom pot at the same time, the amount of water added should be 4cm below the bones of the beef , and then heated up to 103°C at a rate of 10°C / min, and then cooked; then when the above-mentioned cooking until the color of the beef bone soup was off-white, weighed 15g of hydroxyapatite, put it into a mill for grinding, and then milled The obtained powder is put into the beef bone soup and boiled, and when the color of the beef bone soup is milky white, 9g of nano-scale calcium carbonate powder is added thereto, and the temperature is lowered to 70°C for cooking; until the color of the beef bone soup is When the milk is white, add 5g of nano-scale calcium sulfate powder to it, reduce the temperature to 45°C, cook until the beef bone broth boils, then add 11mL of γ-aminopropyltriethoxysilane to it, and st...

example 3

[0023]First weigh 3kg of beef bones, remove the bone marrow from the bones, rinse them with water for 2 times, then put them into a round bottom pot, and add water to the round bottom pot at the same time, the amount of water added should be 5cm below the bones of the beef , and then heated up to 105°C at a rate of 10°C / min, and then cooked; then when the above-mentioned cooking until the color of the beef bone soup was off-white, weighed 20g of hydroxyapatite, put it into a mill for grinding, and then milled The obtained powder is put into the beef bone soup for cooking, and when the color of the beef bone soup is milky white, 10 g of nano-scale calcium carbonate powder is added thereto, and the temperature is lowered to 80° C. for cooking; until the color of the beef bone soup is milky white. When the milk is white, add 6g of nano-scale calcium sulfate powder to it, lower the temperature to 50°C, cook until the beef bone broth boils, then add 12mL of γ-aminopropyltriethoxysil...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
bending strengthaaaaaaaaaa
flexural modulusaaaaaaaaaa
flexural strengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of a nanometer bone repair material, which belongs to the technical field of bone repair material preparation. The present invention takes bovine bones, removes the bone marrow, mixes them with clear water and cooks them, then adds hydroxyapatite, nano-scale calcium carbonate powder and nano-scale calcium sulfate powder in turn and cooks them, then adds γ-aminopropyl triethoxysilane, heat preservation and cooling The slurry is obtained, mixed with fresh water in proportion to feed the shells with a culture solution, and then the slurry is added to the culture solution every day to cultivate it. After the cultivation, the shells are taken out and the pearls are taken out from the shells, which are freeze-dried and ground. , Vacuum drying to prepare nano bone repair material. The beneficial effects of the present invention are: the preparation steps of the present invention are simple, the obtained product has good biocompatibility with human bone, and can effectively induce the growth of bone cells; the mechanical properties of the material are improved by 20-30%, and the bone repair ability is increased by more than 15.6% .

Description

technical field [0001] The invention relates to a preparation method of a nanometer bone repair material, belonging to the technical field of bone repair material preparation. Background technique [0002] Nano-bone repair material is a kind of artificially synthesized material with various excellent physical and chemical properties (self-curing, high mechanical strength, convenient use, etc.) and biological properties (no toxic side effects, absorbable and degradable, good biocompatibility , can induce bone cells and blood vessel growth, etc.) new bone repair materials. Bones are the weight-bearing organs of the human body, which support and protect the human body. There are two main types of bone: cancellous bone and compact bone. The two ends of the long bone are called the marrow, which is composed of cancellous bone, and the middle is called the diaphysis, which is composed of compact bone. The structural unit of compact bone is the Harvard system, and the structure ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/12A61L27/02A61L27/50
CPCA61L27/3604A61L27/025A61L27/12A61L27/365A61L27/50A61L2430/02
Inventor 梅庆波盛海丰
Owner 梅庆波
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap