Preparation method of cartilage regeneration scaffold material for sports wounds in orthopedics department

A technology for scaffold materials and sports trauma, applied in tissue regeneration, medical science, pharmaceutical formulations, etc., can solve problems such as inability to achieve the effect of scaffold materials, affect patients' normal actions, and fast degradation cycle, so as to achieve good regenerative repair effect and guarantee Regeneration effect, good effect

Active Publication Date: 2021-08-03
XIAN HONGHUI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The scaffold material or carrier material of the second-generation technology has a certain activity or induction function. This scaffold can compound bone marrow stromal stem cells, and can make the composite bone marrow stromal stem cells differentiate into chondrocytes. At the same time, this scaffold material can also induce cells from other sources. Form cartilage; this tissue-engineered cartilage has a stronger ability to form cartilage than the first-generation tissue-engineered cartilage, but the surgery still uses an implantation method that does not destroy the subchondral bone
[0003] The cartilage regeneration composite materials currently on the market are not high in mechanical strength, and the degradation cycle is too fast, which cannot play the role of a scaffold material, which will affect the normal movement of the patient after the cartilage is repaired, and even cause secondary damage.

Method used

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  • Preparation method of cartilage regeneration scaffold material for sports wounds in orthopedics department
  • Preparation method of cartilage regeneration scaffold material for sports wounds in orthopedics department
  • Preparation method of cartilage regeneration scaffold material for sports wounds in orthopedics department

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Experimental program
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Effect test

Embodiment 1

[0044] see figure 1 , a preparation method of orthopedic sports trauma cartilage regeneration scaffold material, comprising the following steps:

[0045] S1. First, select cartilage from animals that have just died, and perform ultra-low temperature, purification, inactivation, and cleaning treatments to obtain cartilage granules;

[0046] S2. Cartilage particles are laser cut to obtain nano cartilage powder particles;

[0047] S3, uniformly mixing the nano-cartilage powder, superparamagnetic iron oxide nanoparticles and sodium alginate composite hydrogel to obtain a regenerated colloid;

[0048] S4. The regenerated colloid is used to print the target scaffold material according to the needs through the three-dimensional printing technology, and then the scaffold material is soaked in the cartilage growth solution for 1-1.5 hours to complete the modification of the scaffold material.

[0049] The operation of uniform mixing in S3 is carried out in a constant temperature ultr...

Embodiment 2

[0052] A preparation method for orthopedic sports trauma cartilage regeneration scaffold material, comprising the following steps:

[0053] S1. First, select cartilage from animals that have just died, and perform ultra-low temperature, purification, inactivation, and cleaning treatments to obtain cartilage granules;

[0054] S2. Cartilage particles are laser cut to obtain nano cartilage powder particles;

[0055] S3. Pretreat the superparamagnetic iron oxide nanoparticles. The specific steps of the pretreatment are: spray the surface of the superparamagnetic iron oxide nanoparticles with water-soluble materials in an atomized state, and then stir and dry them to make the superparamagnetic iron oxide nanoparticles Iron oxide nanoparticles are wrapped with a self-dissolving pore-forming water-soluble layer;

[0056] Then, the nano-cartilage powder, the pretreated superparamagnetic iron oxide nanoparticles and the sodium alginate composite hydrogel are uniformly mixed to obtain...

Embodiment 3

[0059] A preparation method for orthopedic sports trauma cartilage regeneration scaffold material, comprising the following steps:

[0060] S1. First, select cartilage from animals that have just died, and perform ultra-low temperature, purification, inactivation, and cleaning treatments to obtain cartilage granules;

[0061] S2. Cartilage particles are laser cut to obtain nano-cartilage powder particles, and the cartilage powder particles are pretreated. The specific processing steps of the pretreatment are:

[0062] First heat the hollow skeleton balls, then place the empty skeleton balls into the container containing the cartilage powder, so that the cartilage powder submerges the hollow skeleton balls, and then perform cooling treatment to shrink the empty skeleton balls and adhere to the cartilage powder Enter into the skeleton hollow ball, make the cartilage powder use the skeleton hollow ball as a carrier, through the setting of the skeleton hollow ball, when repairing ...

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Abstract

The invention discloses a preparation method of a cartilage regeneration scaffold material for sports wounds in the orthopedics department, and belongs to the field of cartilage regeneration. The preparation method of the cartilage regeneration scaffold material for sports wounds in the orthopedics department comprises the following steps: coating a self-disaggregation pore-forming water-soluble layer outside superparamagnetic iron oxide nanoparticles; under the action of cell piece tissue fluid, the self-disaggregation pore-forming water-soluble layer is hydrolyzed, so that the surface of the regeneration scaffold material presents a porous form, and cartilage cells of the regeneration scaffold material are effectively induced to grow towards the interior of the regeneration scaffold material, so that the connectivity between the regeneration scaffold material and the cartilage of a patient is better; in addition, the cartilage powder particles and the cartilage tissue of the patient are effectively induced to jointly grow and proliferate towards the skeleton hollow sphere under the action of the skeleton hollow sphere, so that the repaired cartilage and the skeleton hollow sphere form a whole, and compared with the prior art, the cartilage repairing method has the advantages that the repairing cost is reduced, and the repairing efficiency is improved. The mechanical bearing capacity of the cartilage repaired by the regenerated scaffold material is obviously improved.

Description

technical field [0001] The invention relates to the field of cartilage regeneration, in particular to a method for preparing a cartilage regeneration scaffold material for orthopedic sports trauma. Background technique [0002] The current cartilage tissue engineering and regenerative medical technology materials can be divided into three generations according to the surgical method and design concept. The first generation technology uses periosteum or other cell carriers combined with chondrocytes to repair cartilage defects. The surgical method is to remove cartilage without destroying subchondral bone. , the cells of this technology are mainly derived from the late composite or synovial migration, and the nutrient supply of tissue engineered cartilage (repair material) is mainly supplied by synovial fluid. The scaffold material or carrier material of the second-generation technology has a certain activity or induction function. This scaffold can compound bone marrow strom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/22A61L27/44A61L27/52A61L27/54
CPCA61L27/3612A61L27/3691A61L27/52A61L27/446A61L27/3687A61L27/54A61L27/227A61L2430/06A61L2300/624A61L2300/102A61L2400/16A61L2300/414C08L5/04
Inventor 田斌康鑫张亮
Owner XIAN HONGHUI HOSPITAL
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