The invention provides an EPI SPION, which comprises ferrous chloride, ferric trichloride, sodium metasilicate, carbodiimide, EDC.HCI, N-hydroxyl succinimide and EPI. Fe<3+>, Fe<2+>, SiO3<2-> are taken as main raw materials, and the SPION is prepared through a chemical coprecipitation method; hydroxide radicals which exist on the surface of the SPION have a silane reaction with a silane coupling agent, and an active group carbonyl group is introduced; and by the aid of a nucleophilic reaction between amido and the carbonyl group, the EPI is grafted to the nanoparticle, so that a target product EPI SPION is obtained. The EPI-SPION has good conductivity and magnetic permeability, and under the action of an applied magnetic field, the nanoparticle can reach a tumor diseased region, normal tissue cells are not damaged, and an application value of targeted treatment for tumors is achieved.