T1-T2 double quenching-activated MRI contrast agent and preparation method thereof

A technology of T1-T2 and contrast agent, which is applied in preparations for in vivo tests, pharmaceutical formulations, nanotechnology for sensing, etc. It can solve problems such as long response time and unstable responsiveness, and achieve high sensitivity , fast response speed, and high release efficiency

Active Publication Date: 2022-04-05
广州远想医学生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this stimulus-response dissociation using micelles still has the disadvantages of unstable responsiveness and long response time.

Method used

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  • T1-T2 double quenching-activated MRI contrast agent and preparation method thereof
  • T1-T2 double quenching-activated MRI contrast agent and preparation method thereof
  • T1-T2 double quenching-activated MRI contrast agent and preparation method thereof

Examples

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Embodiment 1

[0049] Example 1 A T1-T2 double quenching-activation MRI contrast agent and its preparation method

[0050] The T1-T2 double-quenching-activation MRI contrast agent of this embodiment has a core-shell structure, which sequentially includes a T2 layer composed of T2 contrast agent, a MOF structure layer composed of metal organic framework particles, and a layer composed of T1 contrast agent. The T1 layer is composed of a metal organic framework particle coated with a T2 contrast agent;

[0051] In the present invention, the T2 contrast agent nanoparticles are oil-phase superparamagnetic iron oxide nanoparticles SPIO with a particle diameter of 10 nm, and the metal organic framework particles are ZIF-8 with a particle diameter of 50 nm; the T1 contrast agent to gadolinium nitrate. The dosage ratio of Fe in the T2 contrast agent to Gd in the T1 contrast agent is 1:20.

[0052] The preparation method of the T1-T2 double quenching-activation MRI contrast agent of this embodiment ...

Embodiment 2

[0061] Example 2 A T1-T2 double quenching-activation MRI contrast agent and its preparation method

[0062] The T1-T2 double-quenching-activation MRI contrast agent of this embodiment has a core-shell structure, which sequentially includes a T2 layer composed of T2 contrast agent, a MOF structure layer composed of metal organic framework particles, and a layer composed of T1 contrast agent. The T1 layer is composed of a metal organic framework particle coated with a T2 contrast agent;

[0063] In the present invention, the T2 contrast agent nanoparticles are oil-phase superparamagnetic iron oxide nanoparticles SPIO with a particle diameter of 8nm, and the metal organic framework particles are ZIF-90 with a particle diameter of 40nm; the T1 contrast agent to gadolinium chloride. The dosage ratio of Fe in the T2 contrast agent to Gd in the T1 contrast agent is 1:15.

[0064] The preparation method of the T1-T2 double quenching-activation MRI contrast agent of this embodiment c...

Embodiment 3

[0071]Example 3 A T1-T2 double quenching-activation MRI contrast agent and its preparation method

[0072] The T1-T2 double-quenching-activation MRI contrast agent of this embodiment has a core-shell structure, which sequentially includes a T2 layer composed of T2 contrast agent, a MOF structure layer composed of metal organic framework particles, and a layer composed of T1 contrast agent. The T1 layer is composed of a metal organic framework particle coated with a T2 contrast agent;

[0073] In the present invention, the T2 contrast agent nanoparticles are oil-phase superparamagnetic iron oxide nanoparticles SPIO with a particle diameter of 12nm, and the metal organic framework particles are ZIF-8 with a particle diameter of 60nm; the T1 contrast agent to gadolinium sulfate. The dosage ratio of Fe in the T2 contrast agent to Gd in the T1 contrast agent is 1:30.

[0074] The preparation method of the T1-T2 double quenching-activation MRI contrast agent of this embodiment com...

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Abstract

The invention discloses a T1-T2 double quenching-activation MRI contrast agent and a preparation method thereof, the MRI contrast agent has a core-shell structure, the core-shell structure sequentially comprises a T2 layer composed of a T2 contrast agent, an MOF structure layer composed of metal organic framework particles and a T1 layer composed of a T1 contrast agent from inside to outside, and one metal organic framework particle coats one T2 contrast agent; the T2 contrast agent is superparamagnetic iron oxide nanoparticles, the T1 contrast agent is a gadolinium-containing ionic compound or a manganese-containing ionic compound, and the dosage ratio of Fe in the T2 contrast agent to Gd or Mn in the T1 contrast agent is 1: (10-40). The MRI contrast agent provided by the invention can realize significant difference imaging signals between normal tissues and acidic lesion tissues, so that the purpose of imaging detection is achieved, and the MRI contrast agent has higher sensitivity, higher response speed and higher release efficiency.

Description

technical field [0001] The invention belongs to the technical field of material science and biomedicine, and more specifically, the invention relates to a T1-T2 double quenching-activation MRI contrast agent and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (MRI) is an imaging technique that uses the signal generated by the resonance of the atomic nucleus in a strong magnetic field to reconstruct the image, and is a nuclear physics phenomenon. It uses radio frequency pulses to excite atomic nuclei with non-zero spins in a magnetic field. After the radio frequency pulses stop, the atomic nuclei relax. During the relaxation process, the signals are collected by induction coils and reconstructed according to certain mathematical methods. Mathematical image. As a non-invasive molecular imaging technology, MRI has the characteristics of high spatial resolution and soft tissue resolution, no radiation, multi-parameter, multi-directional im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/10B82Y15/00B82Y30/00B82Y40/00
Inventor 卢宏伟邹衡芳周晗颜福霞
Owner 广州远想医学生物技术有限公司
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