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Method for preparing monodispersed superparamagnetic iron oxide nanoparticles by pyrolysis of ferrocene

A superparamagnetic iron oxide and nanoparticle technology, applied in iron oxide/iron hydroxide, nanotechnology, nanotechnology, etc., can solve the problems of no iron oxide magnetic nanoparticle research, high requirements for the reaction system, etc., and achieve good magnetic properties Ability, the effect that the size is small

Active Publication Date: 2016-01-27
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The iron sources used in the preparation of iron oxide by thermal decomposition in the existing published literature are mainly iron oleate, iron acetylacetonate and iron pentacarbonyl. There is no research on the preparation of iron oxide magnetic nanoparticles by thermal decomposition of ferrocene, and The current pyrolysis method has high requirements on the reaction system, the solvent must be degassed in advance, and the entire reaction process also needs to be carried out under the protection of an inert gas to ensure that the system is anhydrous and oxygen-free

Method used

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  • Method for preparing monodispersed superparamagnetic iron oxide nanoparticles by pyrolysis of ferrocene
  • Method for preparing monodispersed superparamagnetic iron oxide nanoparticles by pyrolysis of ferrocene

Examples

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Effect test

Embodiment 1

[0021] Example 1: Preparation of superparamagnetic monodisperse nanoparticles by thermal decomposition of ferrocene

[0022] Disperse 0.74g of ferrocene in 20g of octadecene, then add 0.57g of oleic acid, pour it into a three-necked flask with a thermometer and a condenser after dispersing, raise the temperature to 95°C, keep it for 10min, and then increase the temperature at 3.3°C / min The heating rate was raised to 320°C and kept for 3h. When the temperature was lowered to room temperature after the reaction, the product was poured out, and the product was washed 5 times with a mixed solvent of n-hexane and ethanol with a volume ratio of 1:3 to obtain monodisperse superparamagnetic nanoparticles, and finally the product was dispersed in chloroform for storage.

Embodiment 2

[0023] Example 2: Preparation of superparamagnetic monodisperse nanoparticles by thermal decomposition of ferrocene

[0024] Disperse 1.48g of ferrocene in 20g of eicosene, then add 0.57g of oleic acid, pour it into a three-necked flask with a thermometer and a condenser after dispersing, raise the temperature to 90°C, keep it for 20min, and then increase the temperature at 3.3°C / min The heating rate was increased to 330°C and kept for 5h. When the temperature was lowered to room temperature after the reaction, the product was poured out, and the product was washed 5 times with a mixed solvent of n-hexane and ethanol with a volume ratio of 1:3 to obtain monodisperse superparamagnetic nanoparticles, and finally the product was dispersed in chloroform for storage.

Embodiment 3

[0025] Example 3: Preparation of superparamagnetic monodisperse nanoparticles by thermal decomposition of ferrocene

[0026] Disperse 1.48g of ferrocene in 40g of octadecene, then add 6.84g of oleic acid, pour it into a three-necked flask with a thermometer and a condenser after dispersing, raise the temperature to 90°C, keep it for 20min, and then increase the temperature at 3.3°C / min The heating rate was raised to 320°C and kept for 1h. When the reaction is completed and the temperature is lowered to room temperature, the product is poured out, and the product is washed 5 times with a mixed solvent with a volume ratio of n-hexane and ethanol of 1:3 to obtain monodisperse superparamagnetic nanoparticles, and finally the product is dispersed in dichloromethane for preservation .

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Abstract

The invention relates to a method for preparing monodispersed superparamagnetic iron oxide nanoparticles by pyrolysis of ferrocene. The method comprises the following steps: using ferrocene as an iron source and dispersing ferrocene in a high boiling point solvent, adding a surfactant, reacting at high temperature without inert gas shielding, naturally cooling the system after the reaction, fully washing a product with a solvent and removing unreacted raw materials, the high boiling point solvent and the surfactant so as to obtain monodispersed superparamagnetic iron oxide nanoparticles. The invention has advantages as follows: there is no need to prepare an iron source in advance; inert gas shielding is not required during the pyrolysis reaction process; the prepared magnetic nanoparticles are monodispersed and superparamagnetic and have good magnetic performance; specific saturation magnetization reaches 43 emu / g; dimension of the nanoparticles is small, and particle size is 6-10 nm; and the monodispersed superparamagnetic iron oxide nanoparticles can be widely applied in biomedical fields such as magnetic bioseparation, magnetic targeted drug release, magnetic resonance imaging, magnetic biolabeling and the like.

Description

technical field [0001] The invention relates to a method for preparing superparamagnetic iron oxide nanoparticles, in particular to a method for preparing monodisperse superparamagnetic iron oxide nanoparticles by pyrolyzing ferrocene. Background technique [0002] Magnetic nanoparticles are currently a research hotspot in the field of functionalized nanomaterials. Because of their unique magnetic responsiveness, they can be controlled by directional operation through an external magnetic field, which is conducive to the simplification and automation of the reaction process. Therefore, they are widely used in the biological field, such as Bioseparation, targeted drug release, biomagnetic separation, biomagnetic labeling, magnetic resonance imaging and magnetic recording of biochips, etc. Existing methods for preparing iron oxide magnetic nanoparticles mainly include solvothermal method, co-precipitation method, pyrolysis method and the like. Among them, the size and shape o...

Claims

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Application Information

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IPC IPC(8): C01G49/02B82Y30/00
Inventor 张秋禹贾向坤范新龙张宝亮张和鹏
Owner NORTHWESTERN POLYTECHNICAL UNIV
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