T1-T2 double-activated magnetic resonance imaging contrast agent as well as preparation method and application thereof

A magnetic resonance contrast agent, T1-T2 technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, pharmaceutical formulations, preparations for in vivo tests, etc., can solve the problems of poor sensitivity and specificity

Active Publication Date: 2021-03-16
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

but poor sensitivity and specificity

Method used

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  • T1-T2 double-activated magnetic resonance imaging contrast agent as well as preparation method and application thereof
  • T1-T2 double-activated magnetic resonance imaging contrast agent as well as preparation method and application thereof
  • T1-T2 double-activated magnetic resonance imaging contrast agent as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0065] This embodiment provides a T1-T2 dual-activation magnetic resonance imaging contrast agent. The T1-T2 dual-activation magnetic resonance imaging contrast agent uses superparamagnetic iron oxide nanoparticles modified with oleic acid as the core, and is coated sequentially from the inside to the outside. There are silicon dioxide layer and manganese oxide layer, and the outermost layer is modified with polyethylene glycol-phenylboronic acid, and the thickness of the silicon dioxide layer is 4nm. The preparation process of the T1-T2 dual activation magnetic resonance imaging contrast agent is as follows: figure 1 As shown, it specifically includes the following steps:

[0066] (1) Add 1 mg of oleic acid-modified superparamagnetic iron oxide nanoparticles to 5 mL of cyclohexane, sonicate for 5 min, add 0.5 g of polyoxyethylene (5) nonylphenyl ether and 50 μL of ammonia water, and sonicate for 10 min, Add 5 μL of tetraethyl silicate, stir for 2 hours, collect the precipita...

Embodiment 2

[0070] This embodiment provides a T1-T2 dual-activation magnetic resonance imaging contrast agent. The T1-T2 dual-activation magnetic resonance imaging contrast agent uses superparamagnetic iron oxide nanoparticles modified with oleic acid as the core, and is coated sequentially from the inside to the outside. There are silicon dioxide layer and manganese oxide layer, and the outermost layer is modified with polyethylene glycol-phenylboronic acid, and the thickness of the silicon dioxide layer is 8nm. The preparation process of the magnetic resonance imaging contrast agent comprises the following steps:

[0071] (1) Add 1 mg of oleic acid-modified superparamagnetic iron oxide nanoparticles to 5 mL of cyclohexane, sonicate for 5 min, add 0.5 g of polyoxyethylene (5) nonylphenyl ether and 50 μL of ammonia water, and sonicate for 10 min, Add 2 μL of tetraethyl silicate, stir for 12 hours, collect the precipitate by centrifugation, wash with ethanol and water for 3 times, and redi...

Embodiment 3

[0075]This embodiment provides a T1-T2 dual-activation magnetic resonance imaging contrast agent. The T1-T2 dual-activation magnetic resonance imaging contrast agent uses superparamagnetic iron oxide nanoparticles modified with oleic acid as the core, and is coated sequentially from the inside to the outside. There are silicon dioxide layer and manganese oxide layer, and the outermost layer is modified with polyethylene glycol-phenylboronic acid, and the thickness of the silicon dioxide layer is 12nm. The preparation process of the T1-T2 dual activation magnetic resonance imaging contrast agent comprises the following steps:

[0076] (1) Add 1 mg of oleic acid-modified superparamagnetic iron oxide nanoparticles to 5 mL of cyclohexane, sonicate for 5 min, add 0.5 g of polyoxyethylene (5) nonylphenyl ether and 50 μL of ammonia water, and sonicate for 10 min, Add 2 μL of tetraethyl silicate, stir for 24 hours, collect the precipitate by centrifugation, wash with ethanol and water...

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Abstract

The invention provides a T1-T2 double-activated magnetic resonance imaging contrast agent as well as a preparation method and application thereof. The T1-T2 double-activated magnetic resonance imagingcontrast agent has a core-shell structure and sequentially comprises T2 contrast agent nanoparticles, a silicon dioxide layer, a T1 contrast agent layer and a modification layer from inside to outside, and the T2 contrast agent nanoparticles are superparamagnetic iron oxide nanoparticles. The T1-T2 double-activated magnetic resonance imaging contrast agent is in a T1 and T2 contrast agent signaldouble-quenching state in normal tissues around an in-vivo tumor, and T1 and T2 contrast agent signals can be activated at the same time at a tumor part, so that the tumor part and the surrounding normal tissues have a remarkable MRI signal difference, and the T1-T2 double-activated magnetic resonance imaging contrast agent has targeting property on tumor cells, so as to realize high-quality imaging for the tumor part.

Description

technical field [0001] The invention belongs to the technical field of material science and biomedicine, and relates to a T1-T2 dual activation magnetic resonance imaging contrast agent and a preparation method and application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) has the advantages of high resolution, no ionizing radiation damage, multi-parameter, and multi-sequence imaging, and has become one of the most powerful detection methods in contemporary clinical diagnosis. In order to highlight the differences between tissues, especially the difference between normal tissues and diseased parts, contrast agents are often used to improve the imaging contrast. According to the principle of action, MRI contrast agents can be divided into longitudinal relaxation contrast agents (T1 contrast agents) and transverse relaxation contrast agents (T2 contrast agents). T1 contrast agents mainly accelerate T1 relaxation and produce "brightness" in T1-weighted ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08A61K49/18
CPCA61K49/08A61K49/183A61K49/1857
Inventor 田雷蕾卢宏伟张馨丹魏子翔
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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