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Medical nano composite

A nanocomposite, biocompatible technology, applied in biological testing, drug delivery, pharmaceutical formulations, etc., can solve problems such as stable dispersion of hydrophobic SPIO particles

Inactive Publication Date: 2014-07-02
SHANGHAI TREEFUL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, a single dextran alone cannot make the hydrophobic SPIO particles disperse stably in aqueous solution.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Folic acid was selected as the target molecule, folic acid, Freund's immune adjuvant, phospholipid, and cholesterol were mixed and ground in appropriate amounts to prepare the immunogen, and the above immunogen was injected subcutaneously into the thigh and back of mice at multiple points, and blood was collected 30-60 days later to detect the folic acid antibody. The mouse serum was collected to extract the folic acid antibody, and the mouse anti-folate antibody was diluted with PBS buffer and coated with a polyethylene small-well plate under appropriate temperature conditions. During the experiment, an appropriate amount of folic acid was diluted and added to a polyethylene small-well plate coated with anti-folate antibody to incubate for an appropriate time, and unbound free folic acid molecules were washed with PBS buffer solution, vacuum-dried at low temperature, sealed and stored in a refrigerator at 4°C for later use.

[0015] Incubate about 0.5nmol biotin-l...

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PUM

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Abstract

The invention provides a medical nano composite including (a) an oligonucleotides or peptide aptamer for molecular identification; (b) a superparamagnetic iron oxide nanoparticle; and (c) a biocompatible amphiphilic glucan block copolymer carrier used for the superparamagnetic iron oxide nanoparticle and connecting the oligonucleotides or peptide aptamer for molecular identification. The medical nano composite is assembled by use of the aptamer, the superparamagnetic iron oxide nanoparticle, and a polyethylene glycol, polycaprolactone and polysaccharide block copolymer, by use of the targeting effect of specific binding of the aptamer and a target molecule and magnetic resonance imaging (mri) features of the superparamagnetic iron oxide (SPIO) nanoparticle, composite nano micelle is constructed by a biocompatible block copolymer, enters the body for target positioning of small disease focus, and is used for early target positioning diagnosis of minimal lesion in vitro and vivo by use of conventional nuclear magnetic resonance imaging diagnostic equipment. By choosing of an appropriate target molecule aptamer, the medical nano composite also can be used in cell signaling, metabolic process, gene detection, virus detection, tumor detection and other bioresearches.

Description

technical field [0001] The invention relates to a medical nanocomposite, which is suitable for early adjuvant treatment of small lesion localization. Background technique [0002] Due to the current trend of aging society and the increase of people's life expectancy worldwide, people gradually realize the importance of how to achieve personal healthy life. Accordingly, the need for early diagnosis of major diseases such as cancer and other life-threatening diseases has been emphasized, and thus there has been an urgent need to develop a diagnostic technique that can be used for early diagnosis when it is considered necessary and has precise localization of minute lesions. In this context, people have been working hard to develop novel diagnostic and therapeutic technologies, combining the rich biological information obtained from the Human Genome Project with nanotechnology, and using the combination of the two to create highly sensitive and precisely targeted organisms. Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12C12Q1/68C12Q1/70C12Q1/04G01N33/574G01N33/566G01N33/68
Inventor 陈亚玲
Owner SHANGHAI TREEFUL PHARMA
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