The invention provides a
drug-
coating balloon catheter and a production method and application thereof. The method includes: preparing active
drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active
drug seed crystal suspension; adding the active drug
seed crystal suspension, an active drug solution and an additive solution into different channels of a
coating machine, mixing and atomizing the active drug
seed crystal suspension, the active drug solution and the additive solution at the
nozzle tip end of the ultrasonic
sprayer of the
coating machine, spraying to the surface of a
balloon dilatation catheter to obtain
drug coating with an appropriate
crystal size, and performing homogenizing post-
processing to obtain the drug-coating
balloon catheter with homogeneous crystals. The drug-coating
balloon catheter and the production method thereof have the advantages that the
drug coating is firmly combined with a balloon, and
drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the
blood vessel wall of a
lesion part is high, high drug loading efficiency is achieved, intravascular in-situ
stenosis or
restenosis can be treated effectively, the risks of late
thrombosis and
restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.