Preparation method of cartilage regeneration scaffold material for orthopedic sports trauma

Abstract

The invention discloses a preparation method of a cartilage regeneration scaffold material for orthopedic sports trauma, which belongs to the field of cartilage regeneration. A preparation method of a cartilage regeneration scaffold material for orthopedic sports trauma consists of wrapping a layer of self-eliminating superparamagnetic iron oxide nanoparticles Pore-forming water-soluble layer, when repairing damaged cartilage, under the action of cell tissue fluid, the pore-forming water-soluble layer is hydrolyzed, making the surface of the regeneration scaffold material appear porous, effectively inducing its own chondrocytes to move toward the regeneration scaffold material growth, so that the connection between the regenerated scaffold material and the patient's own cartilage is better, and the probability of secondary damage to the repaired cartilage is effectively reduced. The cartilage tissue grows and proliferates together toward the skeleton hollow ball, so that the repaired cartilage and the skeleton hollow ball are integrated, and compared with the prior art, the mechanical bearing capacity of the cartilage repaired by the regenerative scaffold material is significantly improved.

Description

technical field [0001] The invention relates to the field of cartilage regeneration, more particularly, to a preparation method of a cartilage regeneration scaffold material for orthopedic sports trauma. Background technique [0002] The current cartilage tissue engineering and regenerative medicine technology materials can be divided into three generations according to the surgical method and design concept. The first generation technology uses periosteum or other cell carriers combined with chondrocytes to repair cartilage defects. The surgical method is to remove cartilage without destroying subchondral bone. , The cells of this technology mainly come from the late composite or synovial migration, and the nutritional supply of tissue engineered cartilage (repair material) is mainly supplied by synovial fluid. The scaffold material or carrier material of the second generation technology has a certain activity or induction function. This scaffold can compound bone marrow st...

AI Technical Summary

Problems solved by technology

The scaffold material or carrier material of the second-generation technology has a certain activity or induction function. This scaffold can compound bone marrow stromal stem cells, and can make the composite bone marrow stromal stem cells differentiate into chondrocytes. At the same time, this scaffold material can also induce cells from other sources. Form cartilage; this tissue-engineered cartilage has a stronger ability to form cartilage than the first-generation tissue-engineered cartilage, but the surgery still uses an implantation method that does not destroy the subchondral bone

[0003] The cartilage regeneration composite materials currently on the market are not high in mechanical strength, and the degradation cycle is too fast, which cannot play the role of a scaffold material, which will affect the normal movement of the patient after the cartilage is repaired, and even cause secondary damage.

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