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Propofol flexible nano-liposome patch and application thereof

A flexible and nano-liposome technology of propofol, applied in the field of medicine, can solve the problems of strengthening, unsatisfactory effect, slow conditioning effect, etc., achieves enhanced curative effect, avoids liver first-pass effect and gastrointestinal inactivation, and has good effect. Effect

Active Publication Date: 2016-12-14
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 2) Chinese patent medicine: systemic conditioning takes effect slowly
This foot patch introduces medicine into the three yin meridians and three yang meridians of the foot. After the foot receives the medicine, it is transmitted to the corresponding viscera through the three yin and three yang, thereby achieving the effect of strengthening metabolism and promoting sleep. However, the effect of this foot patch is not ideal

Method used

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  • Propofol flexible nano-liposome patch and application thereof
  • Propofol flexible nano-liposome patch and application thereof
  • Propofol flexible nano-liposome patch and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, the preparation embodiment of propofol flexible nano liposome patch

[0078] The invention screens and verifies the dosage range and preparation process of various excipients in the formulation of the propofol-free flexible nano liposome patch. The present invention is described in detail below in conjunction with embodiment, but not limited to following example.

[0079] One, the preparation example of propofol flexible nano liposome

[0080] (1) Propofol flexible nanoliposomes prepared with different ratios of phospholipids

[0081] Example 1.1 Prescription:

[0082]

[0083] Preparation:

[0084] Step 1: Dissolve 1g of propofol, 21g of dipalmitoylphosphatidylcholine, 7g of dipalmitoylphosphatidylglycerol and 5g of cholesterol in absolute ethanol, stir to dissolve, and then depressurize the resulting solution in a water bath at 60°C Remove the organic solvent to prepare a uniform liposome film containing propofol;

[0085]Step 2: Add 20g of sodiu...

Embodiment 2

[0130] Embodiment 2, the preparation embodiment of propofol flexible nano-liposome patch

[0131] (1) Propofol flexible nano-lipid body temperature-sensitive gel patch

[0132] Example 2.1 Prescription:

[0133]

[0134] Preparation:

[0135] Step 1: Dissolve 1g of propofol, 21g of dipalmitoylphosphatidylcholine, 7g of dipalmitoylphosphatidylglycerol and 5g of cholesterol in absolute ethanol, stir to dissolve, and then depressurize the resulting solution in a water bath at 60°C Remove the organic solvent to prepare a uniform liposome film containing propofol;

[0136] Step 2: Add 20g of sodium cholate into water to fully dissolve. After the dissolution is complete, slowly add it dropwise to the liposome film obtained in step 1 under the protection of nitrogen, and disperse at a high speed for 5 minutes under the condition of 10000r / min to elute the phospholipid film And fully swell and hydrate, then adjust the pH to 7.0 with 0.1mol / L NaOH or HCL, and then carry out extru...

Embodiment 3

[0175] Embodiment 3, the quality research of propofol flexible nano-liposome patch

[0176] (1) Particle size and potential detection of propofol flexible nanoliposomes

[0177] A dynamic light scintillation particle size / potential meter was used to detect the particle size and potential of the propofol flexible nanoliposomes prepared in the above three examples, and the results are shown in Table 1.

[0178] Table 1 The particle size of propofol flexible nanoliposomes

[0179]

[0180] *PdI: Polydispersion index polydispersity index (used to measure the particle size distribution range)

[0181] It can be seen from Table 1 that the particle sizes obtained by the above three prescriptions and preparation processes all meet the requirements, and the particle size distribution diagrams are shown in figure 2 , 3 , 4.

[0182] The present invention continued to detect the potential of Example 2.4. The test results are attached Figure 5 As shown, the average value of its...

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Abstract

The invention discloses a propofol flexible nano-liposome patch which can promote sleeping and improve the sleeping quality. The patch is composed of a propofol flexible nano-liposome solution and a substrate layer. The propofol flexible nano-liposome solution is mainly composed of propofol, phospholipids and a flexible agent, wherein the grain size of the solution is tens to hundreds nanometers, and a colloidal solution exists on the appearance. The patch has the advantages of high deformation, high hydrophilia, efficient permeability and high stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a flexible propofol nano liposome patch, a preparation method and an application thereof. Background technique [0002] Sleep problems have become a major hidden danger affecting public health, and about 27% of people around the world suffer from sleep disorders. Most foreign epidemiological surveys show that about 33% of people experience sleep disorders every year, and 17% of them suffer from severe insomnia. Domestic research data show that the incidence of insomnia among Chinese adults is 38.2%, and the incidence of severe insomnia is 9.38%. [0003] Insomnia is characterized by insufficient sleep time, insufficient sleep depth and failure to eliminate fatigue and restore physical strength and energy. Among them, those with insufficient sleep time can manifest as difficulty in falling asleep, easy to wake up at night, difficulty in falling asleep after waki...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/05A61K31/445A61K36/232A61P25/20
CPCA61K9/7023A61K31/05A61K31/445A61K36/232A61K2300/00
Inventor 巨建博陈涛傅经国马玉樊
Owner XIAN LIBANG PHARMA
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