Application of a kind of ursolic acid-aspirin conjugate in preparation of liver-protecting medicine
A technology of aspirin and conjugates, which is applied in the field of medicine and can solve the problems of high establishment requirements, liver cell damage, and inconvenient use
Inactive Publication Date: 2018-11-27
FUZHOU UNIV
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Problems solved by technology
Currently commonly used liver-protecting drugs in clinical practice are limited in use due to high price, inconvenient use, or relatively large side effects.
[0003] The classic liver injury models in research and application mainly include chemical, immune, biological, alcoholic liver injury models, etc. Among them, the establishment of biological liver injury models requires high requirements, and pathogens are susceptible to infection, which limits its application in research. , the immune liver injury model induces an immune response to produce specific antibodies, resulting in liver cell damage
Method used
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Embodiment 1
[0013] Protection of ASP-UA conjugates against carbon tetrachloride-induced liver injury in mice (in vivo liver injury model in animals)
[0014] Drugs and reagents: AST, ALT, SOD kits were purchased from Nanjing Jiancheng Institute of Bioengineering; carbon tetrachloride (CCl 4 , analytically pure), use soybean oil to make a 0.3% soybean oil solution; ursolic acid (UA) standard product is dissolved in soybean oil before use to make a solution; aspirin (ASP) is first used with 7% absolute ethanol Dissolve, then add 7% soybean oil to dissolve, and finally add phosphate buffer to prepare a solution.
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The invention relates to an application of an ursolic acid-aspirin conjugate as shown in Formula I and specifically relates to the application of the ursolic acid-aspirin conjugate in preparing a liver-protecting drug. The determination for AST, ALT and SOD activity proves that the conjugate has a better liver-protecting effect and has a wide application prospect in preparing the liver-protecting drug.
Description
technical field [0001] The invention belongs to the technical field of medicine and relates to a conjugate of ursolic acid and aspirin, in particular to the liver-protecting effect of the ursolic acid-aspirin conjugate and its application in the preparation of liver-protecting medicine. Background technique [0002] The main functions of the liver are to secrete bile, store glycogen, regulate the metabolism of protein, fat and carbohydrates, as well as detoxify, hematopoietic and coagulation. The liver is also the largest detoxification organ in the human body. Toxins and wastes produced in the body, poisons ingested, and drugs that damage the liver must also be detoxified by the liver. The liver decomposes toxic substances absorbed by the intestines or produced by other parts of the body, and then secreted into bile or blood in the form of harmless substances and then excreted from the body, so the liver is one of the most important organs in the human body. Liver disease ...
Claims
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IPC IPC(8): A61K31/616A61K31/56A61K47/55A61P1/16
CPCA61K31/56A61K31/616A61K2300/00
Inventor 邵敬伟赵瑞瑞郭燕沈志春李涛刘亚军
Owner FUZHOU UNIV
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