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A kind of preparation method of enzyme-free glucose sensor electrode material

A technology of glucose sensor and electrode material, which is applied in the direction of material analysis, analysis materials, and instruments by electromagnetic means, can solve problems such as poor stability, and achieve the effects of good sensing performance, wide linear detection range and high performance.

Inactive Publication Date: 2018-08-21
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because glucose oxidase has great sensitivity to environmental factors such as temperature, humidity, and pH value, it has poor stability in the process of production, transportation and storage.

Method used

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  • A kind of preparation method of enzyme-free glucose sensor electrode material
  • A kind of preparation method of enzyme-free glucose sensor electrode material
  • A kind of preparation method of enzyme-free glucose sensor electrode material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 0.25 g of copper nitrate and dissolve it in 4.75 ml of deionized water, then weigh 0.25 g of polyvinylpyrrolidone, add it to the above copper nitrate solution, and stir at room temperature for 12 hours to obtain uniform and clear copper nitrate / Precursor solution of polyvinylpyrrolidone.

[0023] (2) The copper nitrate / polyvinylpyrrolidone precursor solution prepared above was formed on the FTO by a die-drawing method to form a liquid phase film with uniform thickness.

[0024] (3) Slowly put the FTO loaded with the precursor liquid film into liquid nitrogen (about -196 o C), freeze for 10 minutes.

[0025] (4) Quickly transfer the frozen sample to the hanging bottle of the vacuum freeze dryer, and the temperature of the cold trap of the vacuum freeze dryer is -70~-80 o C, the pressure is 10~20 Pa. The drying time is 24 hours.

[0026] (5) Put the vacuum freeze-dried samples into a tube furnace for calcination. start with 1 o The speed of C / min is raise...

Embodiment 2

[0030] The difference between this example and Example 1 is: the polyvinylpyrrolidone in step (1) is 0.125 g. Others are the same as in Example 1.

Embodiment 3

[0032] The difference between this example and Example 1 is: the polyvinylpyrrolidone in step (1) is 0.5 g. Others are the same as in Example 1.

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Abstract

The invention discloses a preparing method and application of electrode material of glucose sensor without enzyme. The method comprises steps of making the prepared aqueous of solution cupric nitrate / PVP polyvinyl pyrrolidone form liquid-phase thin film with uniform thickness on cleaned conductive base; placing the conductive base of the liquid-phase thin film to liquid nitrogen slowly, and calcination treatment in vacuum freeze drying machine; and conducting hydrothermal reduction to get electrode material with three-dimensional open micro-nano porous structure. The electrode material has three-dimensional open macroporous structure, micropore structure and mesoporous structure. As electrode material of glucose sensor without enzyme, the material has good activity of electrocatalytic oxidation, high sensitivity, wide linear response scope, and better selectivity. The preparing technology is simple, has low influence on environment and low cost, and can be put into large scale of production.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensors, in particular to a preparation method and application of an enzyme-free glucose sensor electrode material. Background technique [0002] Diabetes is a frequently-occurring and common disease in the world. At present, the treatment of diabetes is mainly through the frequent monitoring of blood sugar concentration of patients and the injection of appropriate amount of insulin to keep the blood sugar concentration at the normal level of the human body, which can greatly reduce the risk of complications of diabetes. The degree of disease. At present, the more common blood glucose meters on the market are enzymatic glucose biosensors using glucose oxidase as an electrocatalyst. However, because glucose oxidase has greater sensitivity to environmental factors such as temperature, humidity, and pH value, it has poor stability during production, transportation, and storage. Therefore, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
CPCG01N27/3277G01N27/3278
Inventor 邵长路吕娜苗富军李兴华张昕彤刘益春
Owner NORTHEAST NORMAL UNIVERSITY
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