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Preparing method of electrode material of glucose sensor without enzyme

A glucose sensor and electrode material technology, which is applied in the direction of material analysis, analysis materials, instruments, etc. by electromagnetic means, can solve problems such as poor stability, and achieve good sensing performance, high performance, and wide linear detection range.

Inactive Publication Date: 2017-01-11
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because glucose oxidase has great sensitivity to environmental factors such as temperature, humidity, and pH value, it has poor stability in the process of production, transportation and storage.

Method used

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  • Preparing method of electrode material of glucose sensor without enzyme
  • Preparing method of electrode material of glucose sensor without enzyme
  • Preparing method of electrode material of glucose sensor without enzyme

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 0.25 g of copper nitrate and dissolve it in 4.75 ml of deionized water, then weigh 0.25 g of polyvinyl pyrrolidone, add it to the above copper nitrate solution, and stir at room temperature for 12 hours to obtain uniform and clear copper nitrate / Precursor solution of polyvinylpyrrolidone.

[0023] (2) The copper nitrate / polyvinylpyrrolidone precursor solution prepared above is formed on the FTO by the method of drawing a die to form a liquid phase film with a uniform thickness.

[0024] (3) Slowly put the FTO loaded with the precursor liquid phase film into liquid nitrogen (about -196 o C), freeze for 10 minutes.

[0025] (4) Quickly transfer the frozen samples to the hanging bottle of the vacuum freeze dryer, and the temperature of the cold trap of the vacuum freeze dryer is -70~-80 o C, the pressure is 10~20 Pa. Drying time is 24 hours.

[0026] (5) Put the vacuum freeze-dried sample into a tube furnace for calcination. start with 1 o C / min rate from ...

Embodiment 2

[0030] The difference between this example and Example 1 is that the polyvinylpyrrolidone in step (1) is 0.125 g. Others are the same as the specific embodiment 1.

Embodiment 3

[0032] The difference between this example and Example 1 is that the polyvinylpyrrolidone in step (1) is 0.5 g. Others are the same as the specific embodiment 1.

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Abstract

The invention discloses a preparing method and application of electrode material of glucose sensor without enzyme. The method comprises steps of making the prepared aqueous of solution cupric nitrate / PVP polyvinyl pyrrolidone form liquid-phase thin film with uniform thickness on cleaned conductive base; placing the conductive base of the liquid-phase thin film to liquid nitrogen slowly, and calcination treatment in vacuum freeze drying machine; and conducting hydrothermal reduction to get electrode material with three-dimensional open micro-nano porous structure. The electrode material has three-dimensional open macroporous structure, micropore structure and mesoporous structure. As electrode material of glucose sensor without enzyme, the material has good activity of electrocatalytic oxidation, high sensitivity, wide linear response scope, and better selectivity. The preparing technology is simple, has low influence on environment and low cost, and can be put into large scale of production.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensors, in particular to a preparation method and application of an electrode material for an enzyme-free glucose sensor. Background technique [0002] Diabetes is a frequently-occurring and common disease worldwide. At present, the treatment of diabetes is mainly through patients frequently monitoring their own blood sugar concentration and injecting an appropriate amount of insulin to keep the blood sugar concentration at the normal level of the human body, which can greatly reduce the incidence of diabetes complications. degree of morbidity. At present, the more common blood glucose meters on the market are enzyme glucose biosensors with glucose oxidase as the electrocatalyst. However, since glucose oxidase is highly sensitive to environmental factors such as temperature, humidity and pH value, it has poor stability during production, transportation and storage. Therefore, the develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3277G01N27/3278
Inventor 邵长路吕娜苗富军李兴华张昕彤刘益春
Owner NORTHEAST NORMAL UNIVERSITY
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