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Pharmaceutical composition containing trandolapril taste masking composition

The technology of trandolapril and composition is applied in the field of medicine containing trandolapril taste-masking composition, can solve the problems of limited disintegration rate, slow metabolism, poor taste, etc., and achieves strong medical and health care effect, good taste, Good for masking bitterness

Inactive Publication Date: 2017-02-22
ABA CHEM SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the pharmaceutical composition containing the trandolapril taste-masking composition of the present invention has certain shortcomings: 1. Aspartame in the trandolapril taste-masking composition in the formula is an artificial sweetener, and its sweetness is high Due to natural sweeteners, it changes the taste of the medicinal composition to a certain extent, making the taste relatively poor; 2. The disintegrating agent is used in the formula, which can make the medicinal composition disintegrate quickly and overcome the slow absorption and slow metabolism. disadvantages, but the disintegration rate is still limited

Method used

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  • Pharmaceutical composition containing trandolapril taste masking composition
  • Pharmaceutical composition containing trandolapril taste masking composition
  • Pharmaceutical composition containing trandolapril taste masking composition

Examples

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Effect test

Embodiment 1

[0019] This embodiment contains the pharmaceutical composition of trandolapril taste-masking composition, which is composed of the following raw materials in parts by weight: 60 parts of trandolapril taste-masking composition, pregelatinized starch 1500 filler 20 (4 parts of corn starch, 12 parts of potato starch and 4 parts of rice starch), 9 parts of polyvinylpyrrolidone binder, 8 parts of disintegrant and 6 parts of lubricant; wherein, the taste-masking composition of trandolapril consists of 20.13 Parts by weight of mannitol, 20.13 parts by weight of gelatin, 0.29 parts by weight of disodium glycyrrhizinate and 1.45 parts by weight of trandolapril are mixed; 4.52 parts of croscarmellose sodium and 3.48 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 3 parts of magnesium lauryl sulfate and 3 parts of magnesium stearate.

Embodiment 2

[0021] This embodiment contains the pharmaceutical composition of trandolapril taste-masking composition, which is composed of the following raw materials in parts by weight: 60 parts of trandolapril taste-masking composition, pregelatinized starch 1500 filler 20 (4 parts of corn starch, 12 parts of potato starch and 4 parts of rice starch), 9 parts of polyvinylpyrrolidone binder, 8 parts of disintegrant and 6 parts of lubricant; wherein, the taste-masking composition of trandolapril consists of 20.13 Parts by weight of mannitol, 20.13 parts by weight of gelatin, 0.29 parts by weight of disodium glycyrrhizinate and 1.45 parts by weight of trandolapril are mixed; 5.04 parts of croscarmellose sodium and 2.96 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 3 parts of magnesium lauryl sulfate and 3 parts of magnesium stearate.

Embodiment 3

[0023] This embodiment contains the pharmaceutical composition of trandolapril taste-masking composition, which is composed of the following raw materials in parts by weight: 60 parts of trandolapril taste-masking composition, pregelatinized starch 1500 filler 20 (4 parts of corn starch, 12 parts of potato starch and 4 parts of rice starch), 9 parts of polyvinylpyrrolidone binder, 8 parts of disintegrant and 6 parts of lubricant; wherein, the taste-masking composition of trandolapril consists of 20.13 Parts by weight of mannitol, 20.13 parts by weight of gelatin, 0.29 parts by weight of disodium glycyrrhizinate and 1.45 parts by weight of trandolapril are mixed; 4.8 parts of croscarmellose sodium and 3.2 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 3 parts of magnesium lauryl sulfate and 3 parts of magnesium stearate.

[0024] The following table 1 is the mass ratio comparison table of croscarmellose sodium and crospovid...

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Abstract

The invention relates to a pharmaceutical composition containing a trandolapril taste masking composition. The pharmaceutical composition is prepared from, by weight, 60-80 parts of the trandolapril taste masking composition, 10-20 parts of filler, 5-9 parts of adhesive, 6-8 parts of disintegrant and 4-6 parts of lubricant, wherein the trandolapril taste masking composition is formed by mixing mannitol, gelatin, disodium glycyrrhizunate and trandolapril by the ratio of 20:20:0.1:1, and the disintegrant is a mixture of croscarmellose and polyvinylpolypyrrolidone by the mass ratio of (1.3-1.7):1. The pharmaceutical composition has the advantages of being capable of greatly improving the mouthfeel, and the disintegration speed of the pharmaceutical composition is increased.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a medicine containing trandolapril taste-masking composition [0002] with composition. Background technique [0003] Hypertension is defined as elevated arterial systolic and / or diastolic blood pressure at rest. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. There are many reasons for the onset of hypertension, which can be divided into two aspects: genetic and environmental. [0004] In addition, elevated blood pressure is also the fuse of many diseases, which will increase the risk of coronary heart disease, heart failure and kidney diseases. Since some hypertensive patients have no obvious clinical symptoms, hypertension is also known as the "invisible killer" of huma...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K9/20A61K47/42A61K47/26A61K47/10A61K47/36A61K47/32A61K47/20A61K47/12A61P9/12
CPCA61K9/2013A61K9/2018A61K9/2027A61K9/2059A61K9/2063A61K38/05
Inventor 肖方亮周宇张敏康毛建勇
Owner ABA CHEM SHANGHAI
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