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Mobility selective attenuation

A selective, ion-mobility technology that can be used in instruments, analytical materials, discharge tubes, etc., to solve problems such as transmission loss, low duty cycle, and impossibility to control high-mobility ions.

Active Publication Date: 2017-02-22
MICROMASS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is not possible to control the amount of high-mobility ions transferred
[0012] Furthermore, the system disclosed in US-7105808 (Brownberg) has the disadvantage of low duty cycle due to the large transmission losses caused by the grid and preconcentrator arrangement

Method used

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Examples

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Embodiment Construction

[0161] Embodiments will now be described.

[0162] figure 1 An example is shown in which ions are optionally generated in the ion source 1 and then optionally accumulated in the first ion accumulation device 2 . The ion pulse from the first ion accumulator 2 is optionally passed into a first ion mobility spectrometer or separator 3 . Optionally, in a first ion mobility spectrometer or separator 3, the ions are separated according to ion mobility.

[0163] The ions or flow of ions emerging from the first ion mobility spectrometer or separator 3 are optionally attenuated by an attenuation device 4 . The amount or degree of attenuation or the attenuation coefficient is optionally set differently depending, for example, on the elution time and / or ion mobility and / or drift of the ions separated in the first ion mobility spectrometer or separator 3 time. The operation of the attenuation device 4 is optionally synchronized to or with the ion mobility and / or drift of the ions rele...

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Abstract

A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and / or drift time ranges so as to form a second population of ions. The step of selectively attenuating ions comprises applying a varying, increasing or decreasing attenuation factor to ions in different ion mobility and / or drift time ranges. The method further comprises separating the second population of ions according to their ion mobility.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and benefit from UK Patent Application No. 1410052.3, filed 6 June 2014, and European Patent Application No. 14171487.3, filed 6 June 2014. The entire contents of these applications are incorporated herein by reference. technical field [0003] The present invention relates generally to mass spectrometry, and more particularly to mass spectrometers and mass spectrometry methods. Various embodiments relate to apparatus and methods for reducing space charge and saturation effects in ion mobility spectrometry experiments. Background technique [0004] In many cases, the ion population transmitted to an ion mobility spectrometer or separator contains ionic species that are not of interest for a particular analysis, or are so abundant that they can cause downstream ion detectors to saturate or Drift times or peak shapes recorded during ion mobility separations are distorted by space cha...

Claims

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Application Information

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IPC IPC(8): G01N27/62
CPCG01N27/623H01J49/0031H01J49/004
Inventor 马丁·雷蒙德·格林詹森·李·维尔德古斯
Owner MICROMASS UK LTD
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