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Medicine for preventing or treating diabetes, composition and preparation thereof

A kind of pharmaceutical preparation, diabetes technology, applied in the field of medicines, compositions and preparations for the prevention or treatment of diabetes

Active Publication Date: 2017-03-01
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the treatment of diabetes with tervinetin

Method used

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  • Medicine for preventing or treating diabetes, composition and preparation thereof
  • Medicine for preventing or treating diabetes, composition and preparation thereof
  • Medicine for preventing or treating diabetes, composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the hypoglycemic effect of teruciside

[0028] experimental method

[0029] In order to study the effect of teruzhengside on type II diabetes, the classic type II diabetes model was used in this experiment, and C57BL mice were randomly divided into 3 groups, normal control group (10 rats), model group (10 rats), special female Zhenzhi treatment group (10 rats), wherein the model group and the privetin treatment group were modeled with a high-fat diet (20% lard was added to the basal feed) for 8 weeks, and the privetin treatment group was administered orally in the high-fat diet at the same time. Oral gavage (50 mg / kg / d) was administered, and overnight fasting was performed after administration, and fasting blood glucose, glucose tolerance and insulin tolerance were measured.

[0030] Glucose tolerance test method: the mice were fasted overnight, and after oral administration of glucose 2g / kg at 0, 15, 30, 60, 90, and 120 minutes respectively, blood was ...

Embodiment 2

[0054] Example 2: The synergistic hypoglycemic effect of privetin and glimepiride

[0055] Sugar intake disorder is one of the main causes of diabetes. The inventor starved the hepatocytes for 6 hours, and then gave the corresponding treatment with drugs, and took the glucose uptake rate of the hepatocytes as an index of drug efficacy. The sugar intake was measured by the glucose uptake assay kit of Amicate Technology Co., Ltd., and the assay method was carried out according to the instructions. Based on the Median-effect Principle (median-effect principle), applying the CombiDrug statistical Combination Index (CI) to quantitatively evaluate the synergistic, antagonistic or additive relationship between two drugs is a common method for evaluating synergistic effects at present.

[0056] Concrete steps are as follows: drug action effect (fa) is the glucose uptake rate, according to the middle effect equation fa / fu=(D / Dm) m , take the logarithm logfa / fu=mlogD-mlogDm on both ...

Embodiment 3

[0060] Embodiment 3: formulation example

[0061] Teruvirin Tablets

[0062] 10mg of privetin, 88g of starch, 3g of magnesium stearate.

[0063] Preparation process: take privetin, mix with starch and magnesium stearate evenly, make granules, dry, and compress into tablets.

[0064] Tetravirin Capsules

[0065] 10mg of privetin, 88g of starch, 3g of magnesium stearate.

[0066] Preparation process: take privetin, add starch, and magnesium stearate, mix evenly, make granules, dry, pack into capsules, and obtain.

[0067] Teruzhenin Injection

[0068] 47mg of privetin and 7mg of sodium chloride for injection.

[0069] Preparation process: Dissolve privetin with 1.9mL water for injection, add sodium chloride for injection to isotonicity, adjust the pH value to 7-7.1, filter, refrigerate for 24 hours, add water for injection to the specified amount, filter, Potting, sterilization, that is.

[0070] Combination Tablets of Ternvirin and Glimepiride

[0071] 5mg of privetin...

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PUM

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Abstract

The invention discloses a medicine for preventing or treating diabetes, a composition and a preparation thereof. The medicine for preventing or treating diabetes comprises an active component specnuezhenide and glimepiride, and also comprises a pharmaceutically acceptable carrier or an excipient to prepare a pharmaceutically acceptable dosage form. The specnuezhenide has effect for reducing blood glucose, can be used for preventing or treating diabetes, by combining with glimepiride, the effect is better, and specnuezhenide and glimepiride have obvious synergistic interaction.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the discovery of diabetes prevention or treatment medicine, in particular to a medicine, composition and preparation thereof for prevention or treatment of diabetes. Background technique [0002] The World Health Organization released a report on April 6, 2016, stating that the number of diabetic patients in the world has exceeded 400 million, and most of them live in developing countries. In 2014, there were 422 million patients worldwide, accounting for about 8.5% of the global population. This number is only 108 million, or about 4.7% of the global population. The incidence of diabetes in China is also exploding. Blood sugar exceeding the ideal value will increase the risk of cardiovascular disease and other diseases, which makes diabetes an important disease that threatens human health. Diabetes caused approximately 1.5 million deaths worldwide in 2012. [0003] Diabetes mellitus is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/64A61P3/10A23L33/00
CPCA23V2002/00A61K31/64A61K31/7048A61K2300/00A23V2200/328
Inventor 张基田鑫张晓坚梁艳杨志衡薛文华张丽珍常媛媛
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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