Polyethylene glycol modified metal organic nano material and preparation method and application thereof

A metal-organic and nano-material technology, applied in the field of metal nano-materials, can solve problems such as limited applications, and achieve the effects of obvious anti-cancer activity, good dispersibility, and increased half-life

Active Publication Date: 2017-04-26
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the long-term toxicity of inorganic nanocarriers and the degradability of most organic nanomaterials greatly limit their applications in biomedicine.

Method used

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  • Polyethylene glycol modified metal organic nano material and preparation method and application thereof
  • Polyethylene glycol modified metal organic nano material and preparation method and application thereof
  • Polyethylene glycol modified metal organic nano material and preparation method and application thereof

Examples

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preparation example Construction

[0057] The present invention also provides a method for preparing a polyethylene glycol-modified metal-organic nanomaterial, comprising the following steps:

[0058] A) Metal source, organic ligand, polyhistidine-polyethylene glycol, alkali and organic solvent are mixed and reacted to obtain polyethylene glycol-modified metal-organic nanomaterials.

[0059] The selection range and optimization principle of the raw materials in the preparation method in the present invention are consistent with the selection range and optimization principle of the aforementioned polyethylene glycol-modified metal-organic nanomaterials, and will not be repeated one by one again.

[0060] The present invention has no special restrictions on the selection of the metal source, conventional metal salts well known to those skilled in the art can be used, and those skilled in the art can select and adjust according to actual application conditions, raw material conditions and product requirements. The...

Embodiment 1

[0078] One-step preparation of polyethylene glycol-modified cisplatinoid metal-organic nanomaterials (Ca / Pt(IV)@pHis-PEG):

[0079] see figure 1 , figure 1 It is a schematic flowchart of the one-step synthesis of polyethylene glycol-modified metal-organic nanomaterials in the present invention. Such as figure 1 As shown, polyhistidine-polyethylene glycol and cisplatin prodrug Pt(IV)-SA were added to methanol solution containing calcium ions, and Ca / Pt(IV)@pHis-PEG was formed after reaction and dialysis.

[0080] Specific steps:

[0081] Weigh 30 mg of calcium chloride and dissolve it in 60 mL of methanol solution, add 100 mL of triethylamine, and stir at room temperature for 30 min. Weigh 40 mg of synthesized poly-L-histidine-polyethylene glycol pHis-PEG and 30 mg of cisplatin prodrug Pt(IV)-SA solution in 1 mL of DMSO solution, and ultrasonically dissolve them fully. The above-mentioned solution containing cisplatin prodrug and poly-L-histidine-polyethylene glycol was ad...

Embodiment 2

[0085] One-step preparation of a series of polyethylene glycol-modified metal-organic nanomaterials (NMOP-PEG)

[0086] A: Weigh 30mg of calcium chloride and dissolve it in 60mL of methanol solution, add 100mL of triethylamine, and stir at room temperature for 30min. Weigh 40 mg of synthesized poly-L-histidine-polyethylene glycol pHis-PEG and 30 mg of bisphosphorylated cisplatin prodrug Pt(IV) solution in 1 mL of DMSO solution, and ultrasonically dissolve them fully. The above-mentioned solution containing bisphosphorylated cisplatin prodrug and poly-L-histidine-polyethylene glycol was added dropwise into the methanol solution of calcium chloride at a rate of 1 mL / h. After stirring for 24 hours in the dark, unreacted substances were removed by centrifugation, washed twice with methanol, and finally polyethylene glycol-modified cisplatin-like metal-organic nanomaterials (Ca / phosphorylated Pt(IV)@pHis-PEG) were obtained.

[0087] The Ca / phosphorylated Pt(IV)@pHis-PEG prepared i...

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Abstract

The invention provides a polyethylene glycol modified metal organic nano material. The polyethylene glycol modified metal organic nano material is prepared from a metal organic nano material and poly-L-histidine-polyethylene glycol modified on the metal organic nano material. The polyethylene glycol modified metal organic nano material is particularly a poly-L-histidine-polyethylene glycol modified metal organic skeleton nano material and has good dispersibility, long blood circulation time and high tumor enrichment efficiency and very good water solubility and biocompatibility; the polyethylene glycol modified metal organic nano material can serve as a pure medicine carrier-free system and is applied to oncotherapy and particularly treatment of living body level, by means of tail intravenous injection, high enrichment can be achieved on the part of a tumor, and compared with the situation of directly using cisplatin, the antitumor activity is obviously improved; meanwhile, the toxic and side effects are effectively reduced, and damage cannot be caused to other parts.

Description

technical field [0001] The invention relates to the technical field of metal nanomaterials, in particular to a polyethylene glycol-modified metal-organic nanomaterial and a preparation method and application thereof. Background technique [0002] Due to the pollution of the social environment, electromagnetic radiation and the influence of human genetic factors, cancer has become one of several major malignant diseases that threaten human health in the 21st century. Although a large amount of human, material and financial resources have been invested in the prevention and treatment of cancer for decades since the 1950s, the progress made by human beings in this regard is still very limited. [0003] For example, cisplatin (cisplatin) is a non-specific drug for the cell cycle, which can inhibit the DNA replication process of cancer cells and inhibit cell division. features of cross-resistance. Clinically, it can show curative effect on various solid tumors such as ovarian c...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K33/24A61P35/00C08G83/00
CPCA61K33/24A61K47/34C08G83/008
Inventor 刘庄杨宇
Owner SUZHOU UNIV
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