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Products and methods for the identification of hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker

A technology for hepatocellular carcinoma and cell carcinoma, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as low sensitivity and specificity, limited application value, and difficulty in solving pathological diagnosis, so as to improve the quality of life and reduce Economic burden, effect of improving prognosis

Active Publication Date: 2018-07-24
ANHUI MEDICAL UNIV
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Problems solved by technology

[0003] Existing markers for distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinoma include AFP / CA199 / Hep Par1 / CK19, etc., but due to their low sensitivity and specificity, their application value in clinical diagnosis and treatment is currently limited, and it is often difficult to resolve pathological changes. Diagnose the problem

Method used

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  • Products and methods for the identification of hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker
  • Products and methods for the identification of hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker
  • Products and methods for the identification of hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker

Examples

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Embodiment 1

[0020] Example 1. Differentiation of patients with hepatocellular carcinoma and patients with intrahepatic cholangiocarcinoma among patients with primary liver cancer

[0021] Such as figure 1 As shown, the specific method for identifying patients with HCC and patients with intrahepatic cholangiocarcinoma among patients with primary liver cancer is as follows:

[0022] Step S1, collecting paraffin wax specimens of primary liver cancer tumor tissues from 230 primary liver cancer patients with complete clinical and pathological data in a hospital in China in recent years, among which, 150 cases were hepatocellular carcinoma tumor tissue paraffin specimens, and 80 cases were liver tumor tissue paraffin specimens. Paraffin specimens of intracholangiocarcinoma tumor tissue.

[0023] Among them, the diagnosis of primary liver cancer, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma is combined with clinical, histopathological and immunohistochemical staining for compre...

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Abstract

The invention discloses a product and a method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on an MANF as a marker. The invention provides an application of a system for detecting the expression quantity of the MANF in preparation of products for identification or supplementary identification of hepatocellular carcinoma patients and intrahepatic cholangiocarcinoma patients. The hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are identified by taking the MANF as the marker and detecting the expression level of the MANF in a primary hepatocellular carcinoma tissue, a method and an index for effectively identifying the hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are built, the sensitivity is 92.5% and the specificity is 74.7%. A foundation is laid for targeted appropriate treatment and improvement of prognosis of the patients to improve the living quality of the patients and to reduce the economic burden of the patients.

Description

technical field [0001] The invention relates to a product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker in the field of biotechnology. Background technique [0002] Liver space-occupying lesions can be benign or malignant tumors, and malignant tumors can be metastatic or primary. Primary liver cancer (primary carcinoma of the liver) is one of the common malignant tumors in my country. The main types of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). At present, the principle of pathological diagnosis for patients with primary liver cancer after surgery is mainly based on histological examination of surgically resected tumor tissue and clinical examination of patients. Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are often difficult to diagnose due to their similar histological morphology and cross-immune phenotypes; on the other hand, the t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57438
Inventor 沈玉先吴正升李红李庆沈玉君
Owner ANHUI MEDICAL UNIV
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