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A combination of genetic markers, individual genetic ID card, two-dimensional code, kit and use thereof

A technology of genetic markers and two-dimensional codes, applied in recombinant DNA technology, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problems of personal privacy information disclosure and other issues

Inactive Publication Date: 2020-07-28
黄捷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, this kind of SNP detection is generally not used to identify the authenticity of a certain person's sample or the relationship between two people, and the detected SNP sites may contain those sites that have obvious correlations with signs, health and diseases, making the individual's Private information may be disclosed

Method used

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  • A combination of genetic markers, individual genetic ID card, two-dimensional code, kit and use thereof
  • A combination of genetic markers, individual genetic ID card, two-dimensional code, kit and use thereof
  • A combination of genetic markers, individual genetic ID card, two-dimensional code, kit and use thereof

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Experimental program
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Embodiment 1

[0019] Obtaining the Genetic Marker Combinations of the Invention

[0020] According to the embodiment of the present invention, the inventor obtained the SNP sites in Table 1 by designing the following method, that is, through the analysis of mainstream gene chips in the international market, combined with statistical methods, 74 gene sites were found, details as follows:

[0021] First, from Affymetrix, analyze and screen biallelic SNPs (autosome bi-allelic SNPs) in three widely used whole-genome sequences, including Axiom Biobank Array, Axiom UK biobankArray and the newly announced Axiom Precision Medicine Research Array ( PMRA)( http: / / www.affymetrix.com / catalog / prod730013 / AFFY / Axiom%26%23174%3B- Biobank-Genotyping-Arrays#1_3 ).

[0022] From Illumina, analyze and screen biallelic SNPs in three widely used whole-genome sequences, including infinium-omniexpress-24-v1-2-a1 (used by 23&Me), Illumina HumanExome-12v1-2array and the newly announcedGlobal Screening array (G...

Embodiment 2

[0031] Verification of Uniqueness of Genetic Marker Combination

[0032] In order to verify whether the SNP site of the present invention can uniquely mark the individual identity, the present invention utilizes a large database including UK Biobank data (UKBiobank data, N=150,000) and the Million Veteran Program (the Million Veteran Program, N=400,000) The large-scale population data is verified, and the genotypes of the above 74 SNP sites of all individuals in the above-mentioned population are extracted by using PLINK software, and then the uniqueness of the individual genotypes is tested. The results showed that the genotypes of the 74 SNP sites in the above-mentioned population were different and unique.

[0033] Those skilled in the art are well aware that many known methods can be used to type a locus, which is not limited in the present invention. For example, for typing SNP sites, methods that can be used include but are not limited to direct sequencing, fragment len...

Embodiment 3

[0059] The making of the two-dimensional code comprising the gene information of the SNP locus of the present invention

[0060] First, mark all the 74 positions in Table 1 with an index mark such as an index number. For example, each position can be represented by two digits, respectively 01, 02...74. Then high-throughput sequencing analysis was used to type all the 74 loci in Table 1 of the individual samples to obtain the corresponding genotypes. Then, the detection results of each point are matched with the corresponding index values, and a series of combinations of values ​​and symbols are obtained. For example see attached figure 1 , on the left is the genetic information of a sample, followed by the genetic information of this locus. A combination of such values ​​and symbols is used to generate a two-dimensional code through commonly used two-dimensional code generation software and equipment, that is, figure 1 The QR code shown on the right.

[0061] Such a two-di...

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Abstract

The invention discloses genetic marker combination. The genetic marker combination comprises an SNP (single nucleotide polymorphism) site. The invention also discloses an individual gene identity card, a two-dimensional code and a kit. The genetic marker, the individual gene identity card, the two-dimensional code and / or the kit can be effectively applied to individual genetic information authentication and / or individual identity distinguishing.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a combination of genetic markers, an individual gene ID card, a two-dimensional code, a kit and uses thereof. Background technique [0002] Using genetic information to identify whether a genetic sample belongs to a certain person has been very commonly used in judicial identification. The general approach is to detect multiple, for example, 13 genetic loci with high variability in the population. The detection site is called STR (short tandem repeat, short segment repeat sequence), which widely exists in the genomes of humans and mammals and is highly polymorphic. They generally consist of 2-6 bases to form a core sequence. The core sequence is arranged in tandem repeats, and length polymorphisms are generated by changes in the number of core sequence repeats. These loci are highly hereditary and generally do not change from parent to child. But it is generally different...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6888C12N15/11
CPCC12Q1/6888C12Q2600/106C12Q2600/156
Inventor 黄捷
Owner 黄捷
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