Perfume with low irritation to skin and high storage stability and preparation method of perfume
A storage stability and skin irritation technology, applied in the formulation of perfume preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of low perfume stability, affecting the quality of perfume, strong skin irritation, etc. , to achieve the effect of long lasting fragrance, less irritation and less skin irritation
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Embodiment 1
[0025] (1) Add 2g of tocopherol and 1g of paraben into 4g of ethanol, stir until they are completely dissolved, seal, and age at room temperature for 1 month before use;
[0026] (2) 15g butoxydibenzoylmethane, 35g deionized water, 15g sorbitan fatty acid ester, 25g composite stabilizer and step (1) gained mixed solution are added in the emulsifier, at 1300r / min After stirring at low temperature for 25 minutes, aging at -18°C for 7 days, filtering to remove the precipitate, and degassing the filtrate under low pressure to obtain the desired perfume;
[0027] The compound stabilizer described in step (1) is composed of the following parts by weight: 30 parts of polyethylene glycol, 10 parts of cetyltrimethylammonium chloride, 25 parts of 1,4-butanediol and 10 parts of octadecyl Alkylamine polyoxyethylene ether.
[0028] The prepared perfume did not produce precipitation and stratification after one year of storage.
Embodiment 2
[0030] (1) Add 1g of tert-butyl hydroxytoluene and 2g of isothiazolinone into 3g of ethanol, stir until they are completely dissolved, seal, and age at room temperature for 1 month before use;
[0031] (2) 18g ethylhexyl methoxycinnamate, 30g deionized water, 12g polyoxyethylene sorbitan monooleate, 20g composite stabilizer and step (1) gained mixed solution are added in the emulsifier, and Stir at 1200r / min for 20 minutes, age at -18°C for 7 days, filter to remove the precipitate, and degas the filtrate under low pressure to obtain the desired perfume;
[0032] The compound stabilizer described in step (1) is composed of the following parts by weight: 35 parts of polyethylene glycol, 8 parts of cetyltrimethylammonium bromide, 20 parts of 1,4-butanediol and 12 parts of octadecyl Alkylamine polyoxyethylene ether.
[0033] The prepared perfume did not produce precipitation and stratification after one year of storage.
Embodiment 3
[0035] (1) Add 3 g of propyl gallate and 0.5 g of imidazolidinyl urea into 5 g of ethanol, stir until they are completely dissolved, seal, and age at room temperature for 1 month before use;
[0036] (2) 20g musk 105, 40g deionized water, 10g sorbitan fatty acid ester, 30g composite stabilizer and step (1) gained mixed solution are added in the emulsifier, after stirring at 1500r / min for 30 minutes, After aging at -18°C for 7 days, filter to remove the precipitate, and the filtrate is degassed under low pressure to obtain the required perfume;
[0037] The composite stabilizer described in step (1) is composed of the following parts by weight: 40 parts of polyethylene glycol, 15 parts of cetyltrimethylammonium chloride, 30 parts of 1,4-butanediol and 15 parts of octadecyl Alkylamine polyoxyethylene ether.
[0038] The prepared perfume did not produce precipitation and stratification after one year of storage.
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