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Medicated leaven digestion promoting oral composition detection method

A detection method and composition technology, which is applied in the detection field of Shenqu Xiaoshi oral composition, can solve problems such as unsatisfactory chromatographic peak symmetry, decreased theoretical plate number, negative interference, etc.

Inactive Publication Date: 2017-05-31
YANGTZE RIVER PHARM GRP CO LTD +2
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AI Technical Summary

Problems solved by technology

[0007] The existing detection method is not suitable for the detection of the above-mentioned formula composition, the negative is slightly interfered, and the symmetry of the chromatographic peak is not very ideal due to the dissolution of the reference substance in methanol, the number of theoretical plates is usually between 3000 and 4200, and the acid in the mobile phase The content is high, which may have a great impact on the performance of the chromatographic column. As a result, the column will not be used for a long time, and its theoretical plate number will drop and fail to meet the requirements, so it needs to be further optimized

Method used

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  • Medicated leaven digestion promoting oral composition detection method
  • Medicated leaven digestion promoting oral composition detection method
  • Medicated leaven digestion promoting oral composition detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Chromatographic conditions

[0106] Octadecylsilane bonded silica gel is used as filler; acetonitrile-0.1% phosphoric acid solution (14:86) is used as mobile phase; detection wavelength is 232nm. The number of theoretical plates should not be less than 3000 based on the calculation of the peak of paeoniflorin.

[0107] Preparation of reference solution

[0108] Take an appropriate amount of reference substance of paeoniflorin, weigh it accurately, add methanol to make a solution containing 110-120 μg of paeoniflorin per 1 ml, and obtain it.

[0109] Preparation of the test solution

[0110] Precisely measure 10-12ml of this product, add it to a polyamide adsorption column, elute with 30-40ml of water, collect the eluate, put it in a 50ml measuring bottle, add water to the mark, and shake well. Filter with a microporous membrane (0.45 μm), and take the subsequent filtrate, that is, the obtained product.

[0111] Assay

[0112] Accurately draw 10 μl each of the refer...

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Abstract

The invention relates to a medicated leaven digestion promoting oral composition detection method, which comprises the following steps of 1) preparing a reference product solution; taking a paeoniflorin reference product; adding a methanol solution for preparing a paeoniflorin reference product solution; 2) preparing a trial product solution; feeding a polyamide absorption column with a trial product; performing elution by water; collecting elution liquid; performing filtering; taking subsequent filtrate; 3) performing determination; respectively taking the reference product solution and the trail production solution; injecting the reference product solution and the trail production solution into a liquid chromatograph to obtain a chromatogram; calculating the content of active ingredients in the trail product solution according to the peak area.

Description

technical field [0001] The invention relates to a detection method of active ingredients of traditional Chinese medicine, in particular to a detection method of Shenqu Xiaoshi oral composition used for treating children with weak spleen and stomach, stagnant diet and anorexia. Background technique [0002] Anorexia in children refers to long-term loss or disappearance of appetite and reduced food intake as the main symptoms. It is a common disease in children today. Severe cases can cause malnutrition and lack of multivitamins and trace elements, affecting the growth and development of children. [0003] Prior art discloses a kind of Piweining oral liquid such as Hubei College of Traditional Chinese Medicine Journal, Hubei Journal of Traditional Chinese Medicine, Chinese Hospital Pharmacy Journal, etc., which consists of: Hawthorn (fried charred) 75g, Liushenqu (fried charred) 75g, malt (fried charred) 75g, Radix Paeoniae Alba 125g, Codonopsis 75g, Poria cocos 75g, Atractyl...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/08A61P1/14G01N30/02
CPCA61K9/0095A61K36/00A61K36/076A61K36/284A61K36/285A61K36/344A61K36/484A61K36/65A61K36/66A61K36/71A61K36/734A61K36/8998A61K36/9064A61K2236/331A61K2236/39A61K2236/55G01N30/02A61K2300/00
Inventor 相婷郑璐张锴镔吴斌贾瑶王欣王绍青陈思妮
Owner YANGTZE RIVER PHARM GRP CO LTD
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