Method for removing cesium ions in blood

A cesium ion and blood technology, which is applied in the field of blood purification and nuclear medicine emergency, can solve the problem that the flame atomic absorption spectrophotometer cannot meet the detection requirements and takes a long time (it takes days to weeks, and it is not suitable for cesium ion removal) and other issues to achieve the effect of improving biocompatibility, preventing sedimentation, preventing agglomeration and sedimentation

Active Publication Date: 2017-05-31
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to these limitations, current materials and methods for the removal of cesium ions in aqueous solutions are not suitable for the removal of cesium ions in blood
In addition, although the excretion-promoting drug has a high removal rate of cesium ions in the organism, it takes a long time (it takes a few days to a few weeks), so it is not as efficient and fast as direct blood adsorption to remove cesium ions.
[0005] The prior art usually uses a flame atomic absorption spectrophotometer to measure cesium ions in blood. This instrument can only detect cesium ions at the ppm level. When the concentration of cesium ions in the sample to be tested is lower, the flame atomic absorption spectrophotometer can reach Not meet the testing requirements

Method used

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  • Method for removing cesium ions in blood
  • Method for removing cesium ions in blood
  • Method for removing cesium ions in blood

Examples

Experimental program
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Effect test

Embodiment 1

[0033] FeCl 3 ·6H 2 O (1.0g, 3.7mmol) was dissolved in 40mL of ethylene glycol, and then polyethylene glycol (0.1g, M n =2000g / mol), sodium acetate (0.8g, 9.7mmol) and sodium dodecylsulfonate (0.8g, 2.3mmol), then 5mL K 3 [Fe(CN) 6 ]·3H 2 O (0.4 g, 1.0 mmol) aqueous solution was added to the above mixture, and the stirring was continued until the system was uniform, and finally concentrated hydrochloric acid (0.6 mL, 37.5 wt %) was added. The mixture was then transferred to a stainless steel reactor with a polytetrafluoroethylene liner, heated to 180 °C and maintained for 6 hours. Then it was cooled to room temperature, washed once with ethanol, then washed once with water, and finally washed once with ethanol, and vacuum-dried to constant weight to obtain the magnetic Prussian blue adsorbent. Such as figure 1 as shown, figure 1 (A) is the dispersion state diagram of the magnetic Prussian blue nanoparticles in water. In water, the adsorbent dispersion liquid is uniform ...

Embodiment 2

[0044] Fe(NO 3 ) 3 9H 2 O (1.0g, 2.5mmol) was dissolved in 40mL of ethylene glycol, and then polyethylene glycol (0.1g, M n =2000g / mol), sodium acetate (0.8g, 9.7mmol) and sodium dodecylsulfonate (0.8g, 2.3mmol), then 5mL K 3 [Fe(CN) 6 ]·3H 2 O (0.4 g, 1.0 mmol) aqueous solution was added to the above mixture, and the stirring was continued until the system was uniform, and finally sulfuric acid (0.6 mL, 5 mol / L) was added. The mixture was then transferred into a stainless steel reactor with a polytetrafluoroethylene liner, heated to 200 °C and maintained for 6 hours. Then it was cooled to room temperature, washed once with ethanol, then washed once with water, and finally washed once with ethanol, and vacuum-dried to constant weight to obtain the magnetic Prussian blue adsorbent.

[0045] Disperse the above-prepared adsorbent in the blood. After the adsorption is balanced, the adsorbent is sucked out from the blood with a magnet, and 1 mL of blood is taken before and af...

Embodiment 3

[0048] Fe(SO 4 ) 3 ·5H 2 O (1.5g, 3.0mmol) was dissolved in 40mL of ethylene glycol, and then polyethylene glycol (0.1g, M n =2000g / mol), sodium acetate (0.8g, 9.7mmol) and sodium dodecylbenzenesulfonate (0.8g, 2.3mmol), then 5mL of Na 3 [Fe(CN) 6 ]·H 2 O (0.4g, 1.3mmol) aqueous solution was added to the above mixture, and the stirring was continued until the system was uniform, and finally sulfuric acid (0.6mL, 5mol / L) was added. The mixture was then transferred to a stainless steel reactor with a polytetrafluoroethylene liner, heated to 185 °C and maintained for 6 hours. Then it was cooled to room temperature, washed once with ethanol, then washed once with water, and finally washed once with ethanol, and vacuum-dried to constant weight to obtain the magnetic Prussian blue adsorbent.

[0049] Disperse the above-prepared adsorbent in the blood. After the adsorption is balanced, the adsorbent is sucked out from the blood with a magnet, and 1 mL of blood is taken before a...

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Abstract

The invention relates to a method for removing cesium ions in blood. The method comprises the following steps of, in a condition that polyethylene glycol, acetate and an anionic surfactant exist, adding a trivalent iron salt and a ferricyanide aqueous solution into ethylene glycol, and carrying out a closed reaction at 180 to 200 DEG C, so as to obtain magnetic Prussian blue particles; dispersing the magnetic Prussian blue particles in the blood, after adsorption equilibrium, separating the Prussian blue particles adsorbing the cesium ions from the blood. According to the method, an adsorbent having high selectivity and biocompatibility is prepared, and is used for adsorbing the cesium ions in the blood; the method has the characteristics of high efficiency and quickness; meanwhile, by using the method provided by the invention, the cesium ions in the blood can be measured more accurately.

Description

technical field [0001] The invention relates to the fields of blood purification and nuclear medicine emergency, in particular to a method for removing cesium ions in blood. Background technique [0002] In 2011, the Fukushima nuclear power plant accident caused a large amount of radioactive waste to leak, of which 137 The leakage and contamination of Cs are particularly serious. As the main component of radioactive waste liquid, 137 Cs has the characteristics of long half-life (30 years), high volatility, high activity and high solubility, and it is easy to migrate in the environment. Cesium ions can enter the human body through the food chain, and cause teratogenic, carcinogenic, and mutagenic effects, endangering human health. Moreover, the metabolic half-life of cesium ions in the human body needs at least 70 days. Therefore, it is of great strategic significance to study the effective removal of cesium ions in human blood. [0003] The current method for removing c...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): B01D15/00B01J20/22B01J20/28B01J20/30
CPCB01D15/00B01J20/223B01J20/28009B01J20/28016
Inventor华道本钱骏
OwnerSUZHOU UNIV