Method for preparing high-sensitivity bezafibrate molecular imprinting electrochemical sensor

A bezafibrate and molecular imprinting technology, applied in the fields of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of low sensitivity, inappropriate matching of functional monomers with template molecules and cross-linking agents, and poor cross-linking rigidity. and other problems, to achieve the effect of simple equipment, excellent sensitivity, and easy production

Inactive Publication Date: 2017-05-31
GUANGXI UNIV FOR NATITIES
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing high-sensitivity bezafibrate molecular imprinting electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Treatment of glassy carbon electrodes

[0016] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0017] 2. Preparation of molecularly imprinted electrochemical sensor for bezafibrate

[0018] Use water as a solvent to prepare 15ml of a mixed aqueous solution of copper sulfate with a concentration of 0.1mol / L and zinc sulfate with a concentration of 0.1mol / L, and use N,N-dimethylformamide as a solvent to prepare a concentration of 0.02mol / L 40ml of 1,4-cyclohexanedicarboxylic acid solution, then take the prepared 15ml mixed aqueous solution of copper sulfate and zinc sulfate and add it dropwise to the prepared 40ml 1,4-cyclohexanedicarboxylic acid solution at a rate of 5 drops / second. Stir vigorously at a speed of 3000 rpm during th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for preparing a high-sensitivity bezafibrate molecular imprinting electrochemical sensor. According to the method, the high-sensitivity bezafibrate molecular imprinting electrochemical sensor is prepared from bezafibrate as template molecules, ceramide as a functional monomer, azodiisobutyronitrile as an initiator, a copper-zinc double-metal organic frame material as a doping agent and acetylshikonin as a cross-linking agent. The analysis method is simple and practical, and defects that a conventional analysis method is complex, expensive in equipment and low in sensitivity can be overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a highly sensitive bezafibrate molecularly imprinted electrochemical sensor. Background technique [0002] Bezafibrate (Bezafibrate) indications: for the treatment of hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia. However, long-term use of such drugs may cause gallbladder disease, myositis, myopathy and rhabdomyolysis syndrome. Large doses can cause renal and hepatic insufficiency. [0003] The methods for determining bezafibrate include high performance liquid chromatography, chromatography-mass spectrometry, and capillary electrophoresis. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, and low sensitivity. Therefore, it is of great significance to study a highly sensitive and convenient detection method for bezafibrate. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 韦冬萍余会成韦贻春
Owner GUANGXI UNIV FOR NATITIES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap