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Method for preparing high-sensitivity bezafibrate molecular imprinting electrochemical sensor

A bezafibrate and molecular imprinting technology, applied in the fields of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of low sensitivity, inappropriate matching of functional monomers with template molecules and cross-linking agents, and poor cross-linking rigidity. and other problems, to achieve the effect of simple equipment, excellent sensitivity, and easy production

Inactive Publication Date: 2017-05-31
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Method for preparing high-sensitivity bezafibrate molecular imprinting electrochemical sensor

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Embodiment 1

[0015] 1. Treatment of glassy carbon electrodes

[0016] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0017] 2. Preparation of molecularly imprinted electrochemical sensor for bezafibrate

[0018] Use water as a solvent to prepare 15ml of a mixed aqueous solution of copper sulfate with a concentration of 0.1mol / L and zinc sulfate with a concentration of 0.1mol / L, and use N,N-dimethylformamide as a solvent to prepare a concentration of 0.02mol / L 40ml of 1,4-cyclohexanedicarboxylic acid solution, then take the prepared 15ml mixed aqueous solution of copper sulfate and zinc sulfate and add it dropwise to the prepared 40ml 1,4-cyclohexanedicarboxylic acid solution at a rate of 5 drops / second. Stir vigorously at a speed of 3000 rpm during th...

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Abstract

The invention discloses a method for preparing a high-sensitivity bezafibrate molecular imprinting electrochemical sensor. According to the method, the high-sensitivity bezafibrate molecular imprinting electrochemical sensor is prepared from bezafibrate as template molecules, ceramide as a functional monomer, azodiisobutyronitrile as an initiator, a copper-zinc double-metal organic frame material as a doping agent and acetylshikonin as a cross-linking agent. The analysis method is simple and practical, and defects that a conventional analysis method is complex, expensive in equipment and low in sensitivity can be overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a highly sensitive bezafibrate molecularly imprinted electrochemical sensor. Background technique [0002] Bezafibrate (Bezafibrate) indications: for the treatment of hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia. However, long-term use of such drugs may cause gallbladder disease, myositis, myopathy and rhabdomyolysis syndrome. Large doses can cause renal and hepatic insufficiency. [0003] The methods for determining bezafibrate include high performance liquid chromatography, chromatography-mass spectrometry, and capillary electrophoresis. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, and low sensitivity. Therefore, it is of great significance to study a highly sensitive and convenient detection method for bezafibrate. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 韦冬萍余会成韦贻春
Owner GUANGXI UNIV FOR NATITIES
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