A compound natural traditional Chinese medicine preservative composition and its preparation method and application
A technology of preservatives and compositions, which is applied in the field of compound natural traditional Chinese medicine preservative compositions, can solve the problems of reducing the usage of single herbal medicines, and achieve the effects of reducing usage, good application prospects, and good antibacterial broad-spectrum
Active Publication Date: 2019-11-22
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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Problems solved by technology
[0004] However, there is no report on the combination of schisandrin, baicalein and resveratrol used as a preservative in cosmetics and food. The present invention compounded schisandrin, resveratrol and baicalein, and found three After compounding, it has a synergistic bactericidal effect on Escherichia coli, Staphylococcus aureus and Candida albicans, which not only reduces the amount of single drug used, but also expands the antibacterial spectrum of the compound
Method used
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Embodiment 1
[0014] Example 1 Preparation of compound natural traditional Chinese medicine preservative composition and verification of bactericidal effect
[0015] 1 Materials and methods
[0016] 1.1 Experimental materials and instruments
[0017] 1.1.1 Experimental strains
[0018] Escherichia coli (Escherichia coli, ATCC 8739), Staphylococcus aureus (Staphylococcusaureus, ATCC6538), Candida albicans (Candida albicans, ATCC10231), Staphylococcus epidermidis (Staphylococcus epidermidis, ATCC12228)
[0019] 1.1.2 Experimental reagents
[0020] Schisandra B is a white crystal with a purity of 98.8%, which was purchased from the China Institute for Food and Drug Control.
[0021] Baicalein is a yellow needle-like crystal with a purity of 97.8%, which was purchased from the China National Institute for Food and Drug Control.
[0022] Resveratrol is white powder with a purity of 98%, batch number 130423 (Beijing Technology and Business University Plant Raw Materials Technology Laboratory)...
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The invention discloses a compound type natural traditional Chinese medicine preservative composition as well as a preparation method and application thereof. The compound type natural traditional Chinese medicine preservative composition provided by the invention comprises effective components including schisandrin, baicalein and resveratrol. Preferably, the weight ratio of the schisandrin to the baicalein to the resveratrol is (1-3) to (50-100) to (25-50); more preferably 1 to 50 to 25. An experiment process that the compound type natural traditional Chinese medicine preservative composition has a synergetic bactericidal effect on escherichia coli, staphylococcus aureus and Candida albicans; the dosage of a single drug is reduced; and meanwhile, the compound type natural traditional Chinese medicine preservative composition has a good broad-spectrum antibacterial property, can be used for inhibiting growth of common bacteria of cosmetics and cannot be used for completely killing staphylococcus epidermidis. The compound plant-derived preservative disclosed by the invention has the characteristics of safety and high efficiency, can be used in the fields including the cosmetics, medicines, foods and the like, especially skin-care cosmetics, and has a good application prospect.
Description
technical field [0001] The invention relates to a preservative, in particular to a compound natural traditional Chinese medicine preservative composition, which has the characteristics of safety, high efficiency, non-toxicity and no side effects, and good antibacterial broad-spectrum. The preservative can not only kill cosmetics and cannot be detected The growth of bacteria, while the killing effect of Staphylococcus epidermidis, which is a resident bacteria of the skin, is small. Background technique [0002] At present, cosmetics with plant formulations are more and more popular with consumers, and plant extracts are more and more widely used in cosmetics. Traditional Chinese medicine extracts have become a new direction in the research and development of modern natural preservatives because of their antiseptic and cosmetic effects, but the problems of color, odor, stability and unclear ingredients limit their practical applications (plant preservatives and their applicati...
Claims
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IPC IPC(8): A61K8/34A61K8/49A61Q17/00A61Q19/00A61K47/10A61K47/22A23L3/3544
CPCA23L3/3544A61K8/347A61K8/4973A61K8/498A61K47/10A61K47/22A61K2800/524A61Q17/005A61Q19/00
Inventor 宋丽雅何聪芬崔树梅马强王茜贺可可
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY