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A kind of molybdenum dioxide nano-photothermal conversion material and its preparation method and application

A technology of molybdenum dioxide and nano-materials, applied in the field of molybdenum dioxide nano-photothermal conversion materials and its preparation, can solve the problems of affecting light absorption effect, poor biodegradability, weak near-infrared absorption, etc., and achieve excellent photothermal Stability and biocompatibility, simple and rapid preparation method, effect of tumor size reduction

Active Publication Date: 2018-09-25
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The first generation is noble metal nanoparticles represented by gold and silver. These nanoparticles have strong surface plasmon resonance characteristics, so they have good light absorption efficiency, but because of their high price and difficulty in the surface plasmon resonance band The biological window is limited by matching the
The second-generation photothermal materials are mainly graphene-based carbon materials. These materials have a large photothermal conversion area, but their biodegradability is not good, and their near-infrared absorption is weak.
The third-generation materials include CuS and other heavily doped semiconductors and metal compounds. The surface plasmon resonance peak of the semiconductor can be adjusted to the biological window by doping, thereby producing obvious light absorption in the biological window, but the doping makes the surface plasmon resonance The intensity is weakened, which affects the light absorption effect, and the biocompatibility of sulfide is poor, so the application in photothermal therapy is limited
These methods usually require a relatively harsh synthetic environment, the synthesis steps are cumbersome, and the synthesis energy consumption is high. At the same time, these works have not reported the synthesized MoO 2 Has surface plasmon resonance properties

Method used

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  • A kind of molybdenum dioxide nano-photothermal conversion material and its preparation method and application
  • A kind of molybdenum dioxide nano-photothermal conversion material and its preparation method and application
  • A kind of molybdenum dioxide nano-photothermal conversion material and its preparation method and application

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Effect test

Embodiment 1

[0040] The combination of liquid phase laser ablation and solvothermal method is used to prepare molybdenum dioxide nano-photothermal conversion materials, which specifically includes the following steps:

[0041] Step 1, preparation of ethanol and H at a volume ratio of 2:1 2 o 2 The mixed solution, the high-purity molybdenum target (99.99%) is immersed in the mixed solution, stirred and mixed evenly;

[0042]Step 2, focusing a laser beam with a wavelength of 1064nm on the surface of simple molybdenum, with a laser pulse frequency of 10Hz, and ablating the molybdenum target for 20min under 250mJ laser energy to obtain a colloid containing molybdenum oxide nanoparticles;

[0043] Step 3. Insulate the colloid containing molybdenum oxide nanoparticles at 180°C for 2 hours, and perform solvothermal synthesis. After the reaction, cool to room temperature, remove the supernatant, and wash and centrifuge the bottom product of the reaction kettle with ethanol for 6 times. 8000r / min...

Embodiment 2

[0049] The combination of liquid phase laser ablation and solvothermal method is used to prepare molybdenum dioxide nano-photothermal conversion materials, which specifically includes the following steps:

[0050] Step 1, preparing ethanol and H at a volume ratio of 1:1 2 o 2 The mixed solution, the high-purity molybdenum target (99.99%) is immersed in the mixed solution, stirred and mixed evenly;

[0051] Step 2, focusing a laser beam with a wavelength of 1064nm on the surface of simple molybdenum, with a laser pulse frequency of 10Hz, and ablating the molybdenum target for 20min under 250mJ laser energy to obtain a colloid containing molybdenum oxide nanoparticles;

[0052] Step 3. Insulate the colloid containing molybdenum oxide nanoparticles at 160°C for 5 hours, and perform solvothermal synthesis. After the reaction, cool to room temperature, remove the supernatant, and wash and centrifuge the bottom product of the reaction kettle with ethanol for 6 times. 8000r / min, ce...

Embodiment 3

[0055] The combination of liquid phase laser ablation and solvothermal method is used to prepare molybdenum dioxide nano-photothermal conversion materials, which specifically includes the following steps:

[0056] Step 1, preparation of ethanol and H at a volume ratio of 2:1 2 o 2 The mixed solution, the high-purity molybdenum target (99.99%) is immersed in the mixed solution, stirred and mixed evenly;

[0057] Step 2, focusing a laser beam with a wavelength of 1064nm on the surface of simple molybdenum, with a laser pulse frequency of 10Hz, and ablating the molybdenum target for 45min under 100mJ laser energy to obtain a colloid containing molybdenum oxide nanoparticles;

[0058] Step 3. Insulate the colloid containing molybdenum oxide nanoparticles at 220°C for 2 hours, and perform solvothermal synthesis. After the reaction, cool to room temperature, remove the supernatant, and wash and centrifuge the bottom product of the reaction kettle with ethanol for 6 times. 8000r / mi...

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Abstract

The invention discloses a molybdenum dioxide nano photothermal conversion material and a preparation method and application thereof. A high activity solvothermal precursor is obtained by laser ablation of high pure molybdenum in a mixed solution by combination of a liquid phase laser ablation technique and a solvothermal method; and molybdenum dioxide nano nanoparticles are synthesized by reaction under mild conditions by the solvothermal method. The prepared molybdenum dioxide nano nanoparticles have surface plasmon resonance properties, can produce strong light absorption in a near infrared band, can be used for effective conversion of absorbed light into heat so as to kill cancer cells under near infrared laser irradiation, have excellent photothermal stability and biological compatibility, and can be used for the preparation of a photothermal treatment reagent, the photothermal treatment reagent comprising the molybdenum dioxide nano photothermal conversion material is injected into a tumor site, tumor is irradiated by near infrared laser, the growth of the tumor can be effectively inhibited, and the molybdenum dioxide nano photothermal conversion material has wide application prospect in the field of tumor photothermal therapy.

Description

technical field [0001] The invention belongs to the field of photothermal conversion materials, and in particular relates to a molybdenum dioxide nanometer photothermal conversion material and its preparation method and application. Background technique [0002] Photothermal therapy achieves the effect of treating cancer by injecting materials into tumors, using materials to absorb a large amount of light energy in the near-infrared band (biological window) and converting it into heat energy to kill cancer cells. Compared with traditional radiation therapy, chemotherapy and other cancer treatment technologies, photothermal therapy has the greatest advantage in precise treatment. It combines photothermal effect agents with antibodies, and can accurately reach around cancer cells through the targeting of antibodies. No harm to normal cells and tissues. In addition, the course of photothermal therapy is very short, just a few minutes, and has no other side effects. It is a can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G39/02B82Y30/00A61K41/00A61P35/00
CPCA61K41/0052B82Y30/00C01G39/02C01P2002/72C01P2002/82C01P2002/84C01P2004/03
Inventor 邹友生李举彬窦康曾海波刘佳欣
Owner NANJING UNIV OF SCI & TECH
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