Porous bioceramic support and preparation method thereof

Abstract

The invention discloses a porous biological ceramic scaffold and a preparation method thereof. The preparation method comprises: mixing and stacking large particle size paraffin microspheres and small particle size paraffin microspheres, and heating to form a pore forming agent template with a characteristic of radial particle size gradient change; mixing ceramic powder and a dispersing agent solution to obtain a ceramic slurry; injecting the ceramic slurry into the pore forming agent template, and grouting to obtain a ceramic billet; and pre-freezing the ceramic billet, carrying out freeze drying, dewaxing and sintering the ceramic billet, and cooling to obtain the porous biological ceramic scaffold. According to the present invention, the large particle size paraffin microspheres and the small particle size paraffin microspheres are subjected to the mixing stacking, and the heating is performed to form the pore forming agent template with the characteristic of radial particle size gradient change, such that the pore structure of the prepared porous biological ceramic scaffold is close to the structure of the natural bone, and the prepared porous biological ceramic scaffold is the excellent bone repair material.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a porous bioceramic support and a preparation method thereof. Background technique [0002] Compared with the traditional bone repair solutions - autologous bone, allogeneic bone and xenogeneic bone materials, artificial bone repair materials have the advantages of no immune rejection, no risk of animal origin, low cost, wide range of sources, and exemption from secondary surgery for patients. It is considered to be one of the most promising bone repair materials. [0003] In order to make it easier for cells and blood vessels to grow into the material to promote the rapid formation of new bone tissue, artificial bone repair materials are often prepared in the shape of a connected porous scaffold that mimics the natural bone structure. The natural bone structure is a radial gradient structure with a loose interior and a relatively dense exterior. Holes of different sizes are sui...

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Problems solved by technology

Liu Weijian et al. (Preparation and Characterization of Gradient Scaffold Materials for Tissue Engineering, Beijing University of Chemical Technology, 2006) used a stacking template of sodium chloride particles with different particle sizes. Although the template has a certain gradient structure, the sodium chloride particle It is square, and the uniformity of the interconnected pores formed after stacking is low. In addition, the polylactic acid and the porogen are mixed first and then injected into the mold. The pore structure of the obtained porous bioceramic scaffold is quite different from that of natural bone, which affects the application

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