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Solid phase extraction sample pretreatment device and treatment method

A sample pretreatment and extraction technology, applied in the field of extraction, can solve problems such as processing and impossible blood samples, and achieve the effects of reducing diffusion, saving dosage, and improving separation efficiency

Active Publication Date: 2019-12-13
GUANGDONG RANGER BIOSCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If personalized medicine is implemented for most drugs to achieve the goal of precision medicine, no matter how large a hospital is, it is impossible to accommodate patients waiting for blood collection, let alone process all blood samples one by one with existing solid-phase extraction columns

Method used

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  • Solid phase extraction sample pretreatment device and treatment method
  • Solid phase extraction sample pretreatment device and treatment method
  • Solid phase extraction sample pretreatment device and treatment method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Please refer to figure 1 , the solid phase extraction sample pretreatment device 100 according to the present invention includes a columnar piston 10 and a cylindrical container 20, and the columnar piston and the cylindrical container 20 are mutually sealed. Cylindrical piston 10 comprises piston main body 12, collecting container 13, packing column 14, guide tube 15 and top cover 16, and piston main body 12 is a cylindrical body, and its bottom end has opening or bottom end has perforation, and opening or perforation are used. The sample is applied to the packing as it is loaded into the packing column 14 within the piston body 12 and in use. In this embodiment, the cylindrical piston 10 is a cylindrical piston, and the cylindrical container 20 is a cylindrical container. In other embodiments, the cylindrical piston 10 and the cylindrical container 20 may also be polygonal cylindrical.

[0046] In order to facilitate chromatographic separation, the external diameter...

Embodiment approach

[0053] The above-mentioned solid-phase extraction sample pretreatment device 100 was used for blood sample processing, and the modified cotton fibers carded into parallel lines were used as fillers, the length of the filler part was 26 mm, and the inner diameter was 1.5 mm. The human blood serum with the standard addition of reserpine was used as the sample, the concentration was 1ppm. The experimental steps are: put the columnar piston 10 upside down, directly add 20 microliters of the above-mentioned human blood serum sample into the packing column 14 with a pipette gun, then add 250 microliters of pure methanol into the cylindrical container 20, and stabilize the columnar piston 10 Insert the cylindrical container 20 and slowly press it down. At this time, the methanol in the cylindrical container 20 flows through the filler and the guide tube to elute the reserpine into the collection container 13, and the collected solid-phase extraction device is directly sent as a sample...

Embodiment 2

[0056] Please refer to image 3 The solid phase extraction sample pretreatment device 200 of the present invention includes a hollow column 201 with two ends open and a conduit 202. The hollow column 201 sequentially includes a liquid holding section 203 and a packing section 204 from the top to the bottom. The liquid holding section The diameter of 203 is greater than the diameter of packing section 204, and conduit 202 is arranged on the bottom of packing section 204 and is communicated with packing section 204, is filled with linear packing in packing section 204, and linear packing is along the axis of packing section 204 by the bottom of packing section 204 The ends are filled into the packing segment 204 and aligned in parallel. Wherein, hollow column 201 can be made of materials such as plastics, metal, glass, pottery, wood, and the diameter of conduit 202 is less than the diameter of packing section 204, and the inner diameter of packing section 204 is aV millimeter, a...

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Abstract

The invention discloses a pre-treatment device and a treatment method for a solid phase extraction sample. The device comprises a columnar piston and a cylindrical container; the cylindrical piston comprises a piston main body, a collecting container, a filler column, a flow guide tube and a top cover; the piston main body is hermetically matched with the cylindrical container; the collecting container is located in the piston main body and the top end of the collecting container has an opening and is closed by the top cover; the filler column is arranged in the piston main body, and the bottom end of the filler column communicates with the bottom end of the piston body and an opening is formed in the bottom end of the filler column; the top end of the filler column communicates with the collecting container through the flow guide tube; the filler column is filled with linear filler, and the liner filler is filled to the filler column from the opening in the bottom of the filler column along the axis of the filler column and is arranged in parallel. According to the pre-treatment device and the treatment method for the solid phase extraction sample disclosed by the invention, trace amount of sample can be treated, the separating efficiency is relatively high, the universality is high and the dosage of a solvent is small.

Description

technical field [0001] The invention relates to the technical field of extraction, in particular to a solid-phase extraction sample pretreatment device and a use method thereof. Background technique [0002] In most cases in the chemical analysis process, the sample must be pretreated to separate the analyte from the sample and concentrate it. The purpose is to eliminate the interference of the sample base material on the analysis and detection and improve the sensitivity and accuracy of the analysis. The most commonly used sample processing methods mainly fall into three categories: solid-phase extraction, liquid-liquid extraction, and precipitation separation. It is generally necessary to develop specific pretreatment devices for different samples. The most time-consuming link in establishing a complete analytical method is often the development of sample pretreatment, and the most time-consuming and laborious step to complete the analysis of a sample is often also sample ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06
CPCG01N30/06
Inventor 朱建雄
Owner GUANGDONG RANGER BIOSCI CO LTD