A kind of traditional Chinese medicine composition and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and application, can solve problems such as no significant improvement in daily life and neuropsychiatric symptoms, psychosis, limited clinical application, poor clinical treatment effect, etc., to improve behavioral disorders , Excellent efficacy

Active Publication Date: 2020-12-29
JILIN INST OF CHEM TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main drugs for the treatment of AD are western medicines. The traditional drugs for the treatment of AD are mainly acetylcholinesterase inhibitors. By inhibiting acetylcholinesterase, the degradation of acetylcholine released from the central nervous system of the cerebral cortex is slowed down, thereby increasing the concentration of acetylcholine and improving the cognitive function of AD patients. and behavioral disorders, delaying the occurrence of the disease, but the clinical treatment effect is not good, so its clinical application is greatly limited
Moreover, acetylcholinesterase inhibitors only solve the "standard" problem without changing the "essence". These drugs can only improve the symptoms (such as cognitive ability) of AD patients in a short period of time (6-12 months), and they are not beneficial to patients. There is no significant improvement in daily life and neuropsychiatric symptoms (such as affective disturbance, anxiety, psychosis, etc.)

Method used

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  • A kind of traditional Chinese medicine composition and application
  • A kind of traditional Chinese medicine composition and application
  • A kind of traditional Chinese medicine composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Pharmacodynamic study of polygala saponin and ginsenoside composition improving AD behavioral disorder

[0035] 1.1 Experimental method

[0036] 1.1.1 Experimental grouping and administration

[0037] Wistar rats, male, weighing 180-220 g, were purchased from the Animal Experiment Center of Bethune School of Medicine, Jilin University, license number: SCXK (Ji) 2015-0007.

[0038] After one week of adaptive feeding, they were randomly divided into 7 groups, namely: blank group, model group, polygala saponin group, ginsenoside group, polygala saponin and ginsenoside combination 1:1 group, polygala saponin and ginsenoside combination 2:1 group, Polygala saponin and ginsenoside combination 1:2 group.

[0039] Except the blank group, all other groups were intraperitoneally injected with D-galactose 60mg / kg and gavaged with AlCl 3 200mg / kg for modeling, once a day for 60 days. On the 30th day, the blank group and the model group were given double distilled wat...

Embodiment 2

[0088] Example 2 Polygala saponin and ginsenoside composition on the pathological morphology of brain hippocampus in AD rats

[0089] 2.1 Experimental method

[0090] Decapitate the rat, take the brain, separate the hippocampal tissue and cortex, fix the hippocampal tissue by immersing in 4% paraformaldehyde, prepare paraffin sections by dehydration, wax immersion, and paraffin embedding, and then go through xylene dewaxing, descending gradient alcohol water, etc. Hematoxylin and eosin staining, gradient ethanol dehydration, xylene transparency, and neutral gum sealing were performed to prepare HE-stained myocardial tissue sections, and observe the pathological changes of hippocampal tissue under an optical microscope.

[0091] 2.2 Experimental results

[0092] The brain tissues of the rats in each group were taken, and the hippocampus was stained with HE. The results were as follows: the hippocampus and subcortical neurons in the blank group were intact, the nuclei were not ...

Embodiment 3

[0093] Example 3 Effect of polygala saponin and ginsenoside composition on the expression of related proteins in the brain of AD rats

[0094] 3.1 Experimental method

[0095]Four proteins related to the occurrence and development of AD in rat brain tissue: p-tau , GSK3, Aβ, and PP2A levels were expressed, GAPDH was used as an internal reference protein, and image J image processing software was used for grayscale analysis.

[0096] 3.2 Experimental results

[0097] Compared with the blank group, the levels of Aβ, p-tau, and GSK3 in the model group increased; compared with the model group, the composition of polygala saponins and ginsenosides could significantly reduce the levels of three proteins in the brain, p-tau, GSK3, and Aβ, and increase the protein level of PP2A. level, improve the cognitive impairment of AD rats, see the results Figure 4 , Figure 4 It is the expression chart of protein content in rats in each group, where A is the blank group, B is the model gro...

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Abstract

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises tenuigenin and ginsenoside, and a mass ratio of tenuigenin to ginsenoside is smaller than or equal to 1. Compared with the prior art, the traditional Chinese medicine composition has advantages that by joint use of two effective parts including tenuigenin and ginsenoside, behavioral disorder of rat with Alzheimer's disease can be remarkably improved, exact effects in treatment of Alzheimer's disease are achieved, and efficacies are evidently superior to those of any one of tenuigenin and ginsenoside in single use.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition and its application. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology, with cognitive decline as the main clinical manifestation, mainly manifested as progressive intellectual impairment, memory loss, accompanied by personality and emotional changes. With the aging of the population in our country, AD has become a serious social problem. Therefore, it is very necessary and significant to find various ways to realize the research work of treating and alleviating AD. [0003] At present, the main drugs for the treatment of AD are western medicines. The traditional drugs for the treatment of AD are mainly acetylcholinesterase inhibitors. By inhibiting acetylcholinesterase, the degradation of acetylcholine released from the central nervous system of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/69A61P25/28A23L33/10
CPCA23V2002/00A61K36/258A61K36/69A61K2300/00A23V2200/322
Inventor 张艳李卉金刚张扬杨秀东曲小姝
Owner JILIN INST OF CHEM TECH
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