Red peony root injection and its preparation method

An injection, the technology of Radix Paeoniae Rubra, applied in the field of preparation of Radix Radix Radix Radix Radix Paeoniae Rubra Injection, can solve the problems of low active ingredient content, unstable quality, and affecting therapeutic effect, etc., and achieve high bioavailability, rapid onset of effect, and good therapeutic effect Effect

Inactive Publication Date: 2005-11-02
秦吉兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chishao injection currently used clinically is a small water needle prepared by the hydroalcoholic method, which has low content of active ingredients and unstable quality, which affects the therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 400g of Radix Paeoniae Rubra, cut into decoction pieces, use 6 times the amount of 70% ethanol to reflux extract twice, the first time for 2 hours, and the second time for 1 hour, combine the extracts, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relatively high temperature. For clear paste with a density of 1.18 (50°C), add 4 times the amount of water, stir well, refrigerate for 24 hours, centrifuge at a high speed (20000r / min), and concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.25 (50°C). Add ethanol to make the alcohol content to 85%, refrigerate for 24 hours, filter the supernatant and add ammonia water to adjust the pH to 8.0, refrigerate for 24 hours, filter, recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.08 (50°C) The concentrated solution was extracted 4 times each time with an equal volume of water-saturated n-buta...

Embodiment 2

[0013] Take 300g of Radix Paeoniae Rubra, cut into decoction pieces, reflux extract with 8 times the amount of 60% ethanol for 3 times, each time for 1.5 hours, combine the extracts, filter, and recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.23 (50°C) Add 3 times the amount of water, stir evenly, refrigerate for 36 hours, centrifuge at a high speed (20000r / min), concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.27 (50°C), add ethanol to make the alcohol content to 80%, refrigerated for 48 hours, filtered the supernatant and added ammonia to adjust the pH to 8.0, refrigerated for 28 hours, filtered, the filtrate was decompressed to recover ethanol and concentrated to a concentrated solution with a relative density of 1.14 (50°C), and added to the macropore On the adsorption resin chromatography column, first elute with water 30 times the weight of the concentrated solution, discar...

Embodiment 3

[0015] Take 1000g of Radix Paeoniae Rubra, cut into decoction pieces, reflux extract with 8 times the amount of 70% ethanol for 3 times, each time for 1 hour, combine the extracts, filter, and recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.16 (50°C) Add 5 times the amount of water, stir evenly, refrigerate for 36 hours, centrifuge at a high speed (20000r / min), concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.26 (50°C), add ethanol to make the alcohol content to 85%, refrigerated for 24 hours, filtered the supernatant and added ammonia water to adjust the pH to 8.0, refrigerated for 30 hours, filtered, and the filtrate was decompressed to recover ethanol and concentrated to a concentrated solution with a relative density of 1.10 (50°C). The volume of water-saturated n-butanol was extracted 5 times, the extracts were combined, the n-butanol was recovered under reduced pressure and...

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PUM

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Abstract

The present invention is one kind of red peony injection prepared with red peony root as material and through alcohol extraction, n-butanol extraction or macroporous resin purification, and adding proper amount of medicinal supplementary material and injection water. It is stable and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic experiment shows that the medicine of the present invention can improve the behavior disorder of rat with cerebral infarction obviously, reduce the area of cerebral infarction, decrease water content in infracted brain tissue, reduce the peroxidation damage of lipoid in brain tissue and raise the acute oxygen lack tolerance of mouse and thus has excellent treat effect on cerebral infarction.

Description

technical field [0001] The invention relates to a preparation method of Radix Paeoniae Rubra Injection. Background technique [0002] Radix Paeoniae Rubra is a traditional traditional Chinese medicine, which is derived from the dried root of Paeonia Lactiflora Pall. or Paeonia veilchii Lyncnn. It is recorded in the "Pharmacopoeia of the People's Republic of China" 2000 edition. It has the effects of clearing away heat and cooling blood, dissipating blood stasis and relieving pain. Meridian, fall injury embolism. Pharmacological studies in recent years have shown that Radix Paeoniae Rubra has many pharmacological effects such as protecting the heart, increasing coronary blood flow, anti-thrombosis and atherosclerosis, sedative and analgesic, anti-inflammatory, anti-bacterial, and anti-oxidant. Phytochemical research results show that the main active ingredients of red peony are paeoniflorin, paeoniflorin, hydroxypaeoniflorin and other monoterpenoids. At present, the Chisha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61P7/02A61P9/10
Inventor 秦吉兴
Owner 秦吉兴
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