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Polymeric biguanide preservation of precipitated calcium carbonate

A technology of precipitating calcium carbonate and polymerizing biguanide, which can be used in pharmaceutical combinations, medical preparations containing active ingredients, dentistry, etc., and can solve problems such as ineffective long-term preservatives and instability

Inactive Publication Date: 2017-08-29
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, glutaraldehyde is unstable at alkaline pH and therefore not effective as a long-term preservative

Method used

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  • Polymeric biguanide preservation of precipitated calcium carbonate
  • Polymeric biguanide preservation of precipitated calcium carbonate
  • Polymeric biguanide preservation of precipitated calcium carbonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Poly[(hexamethylene)biguanide] (PHMB) was added during the PCC manufacturing process. Specifically, PHMB was added after neutralizing the freshly precipitated calcium carbonate slurry with phosphoric acid. Slurry samples were subjected to the Micro Robustness Test (MRT), a challenge test to evaluate the antimicrobial efficacy of PHMB against a pool of microorganisms including:

[0059] Burkholderia cepacia ( Burkholderia cepacia )

[0060] Enterobacter cloacae ( Enterobacter cloacae )

[0061] Escherichia coli ( Escherichia coli )

[0062] Klebsiella oxytoca ( Klebsiella oxytoca )

[0063] Klebsiella pneumoniae ( Klebsiella pneumoniae )

[0064] Serratia marcescens ( Serratia marcescens )

[0065] Providencia rettii ( Providencia retgeri )

[0066] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0067] Pseudomonas putida ( Pseudomonas putida )

[0068] Staphylococcus aureus ( Staphylococcus aureus )

[0069] Staphylococcus saprophyticus ...

Embodiment 2

[0076] The preservative activity of PHMB-associated PCC in toothpaste formulations was tested. PHMB-associated PCC was formulated into each of two toothpaste formulations (formulations A and B) including sorbitol, carboxymethylcellulose, sodium lauryl sulfate, monofluorophosphate, sodium bicarbonate, Sodium silicate, flavoring and water, and subjected to MRT testing as described in Example 1.

[0077] Table 2

[0078]

[0079]Formulation A includes sorbitol, sodium saccharin, sodium carboxymethylcellulose, sodium monofluorophosphate, sodium bicarbonate, sodium lauryl sulfate, sodium silicate, water, flavor A, and PCC preserved with PHMB; formulation B includes sorbitol Sugar Alcohols, Sodium Saccharin, Sodium Carboxymethylcellulose, Sodium Monofluorophosphate, Sodium Bicarbonate, Sodium Lauryl Sulfate, Sodium Silicate, Water, Fragrance B and PCC Preserved with PHMB. Consistent with the data from Example 1, a PHMB concentration of 0.03% proved to be sufficient to preserve ...

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Abstract

Biguanide-preserved precipitated calcium carbonate oral care compositions and methods of manufacture thereof are disclosed.

Description

[0001] This application is a divisional application of an invention patent with an application date of December 17, 2010, an application number of 201080057673.0, and an invention title of "Polymeric Biguanide Anticorrosion of Precipitated Calcium Carbonate". [0002] Cross References to Related Applications [0003] This application claims priority to US Provisional Patent Application Serial No. 61 / 287,847, filed December 18, 2009, which is incorporated herein by reference. Background of the invention [0004] Precipitated calcium carbonate (PCC) is manufactured on an industrial scale for use in a variety of industrial, cosmetic and pharmaceutical products. Generally, precipitated calcium carbonate is produced by heating crushed limestone at high temperature to decompose the raw calcium carbonate into lime (CaO) and carbon dioxide gas (CO 2 ). Adding water to lime (a process called "digestion") yields Ca(OH 2 ). The digested lime (or "milk of lime") is treated with carbon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/43A61K8/19A61Q11/00A61K8/84
CPCA61K8/19A61K8/43A61K8/84A61K2800/30A61K2800/524A61Q11/00A61P1/02
Inventor N.施莫希劳O.T.亚马内A.科雷亚K.科斯塔E.乌蒂马A.S.戴维
Owner COLGATE PALMOLIVE CO