Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system

A bioreactor and decellularization technology, applied in the field of waste purification systems and systems that automatically implement organ decellularization programs, can solve problems such as disadvantages, waste of time and resources, and increased risk of pollution

Pending Publication Date: 2017-08-29
UNITED THERAPEUTICS CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Human intervention and manipulation during manually performed decellularization protocols increases the risk of contamination, reduces the consistency of the final product, an

Method used

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  • Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system
  • Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system
  • Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system

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[0016] overview

[0017] The automated bioreactor system described herein provides a bioreactor that can be configured to automatically perform all steps of a decellularization protocol, after initiation of which requires little or no user input for successful execution of the protocol. The automated bioreactor system includes a main chamber in which decellularization occurs and a series of reagent chambers supplying the main chamber with reagents required to facilitate decellularization in a continuous closed conduit. A control cell with a controller and user interface was incorporated into the automated bioreactor system to fully automate the decellularization process in a closed system via valves and pumps that direct the flow of reagents through the steps of the protocol. By providing full automation of the decellularization process, the direct interface between humans and the components of the bioreactor is reduced, thereby increasing sterility, consistency, and efficie...

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Abstract

An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 044,647, filed September 2, 2014, which is incorporated herein by reference in its entirety. field of invention [0003] The systems and methods described herein generally relate to bioreactors and systems therefor, and more specifically, to automated bioreactor systems for organ decellularization, systems for automating organ decellularization protocols, and bioreactor systems. Waste purification system. Background technique [0004] Although allogeneic lung transplantation is a treatment for advanced lung disease, the number of patients waiting for lung transplantation has steadily increased and only a small proportion of patients receive organ transplantation due to the limited number of donor organs. For example, chronic obstructive pulmonary disease (COPD) affects more than 64 million people worldwide. The World Health Organization...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247A61L2/0017A61L27/36G01G19/00G01K13/02G01L7/00
Inventor R·邦维兰J·切多T·彼得森
Owner UNITED THERAPEUTICS CORP
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