New Uses for Grass Fruit Oil

A kind of grass fruit oil and grass fruit technology, applied in the field of medicine, can solve the problems of no relevant literature reports, etc., and achieve the effect of not easy to produce drug resistance, enhance in vitro anti-MRSA activity, safe and non-toxic to produce drug resistance

Active Publication Date: 2021-03-12
CHENGDU MEDICAL COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of "super" drug-resistant bacteria, especially methicillin-resistant Staphylococcus aureus infection, there is no relevant literature report

Method used

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  • New Uses for Grass Fruit Oil
  • New Uses for Grass Fruit Oil
  • New Uses for Grass Fruit Oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 medicament grass fruit oil of the present invention

[0021] Take the grass fruit, crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak for 1-5 hours, and extract it by steam distillation for 2-6 hours to obtain the grass fruit oil of the present invention.

[0022] The grass fruit oil of the present invention can also be extracted according to the pharmacopoeia (2005 edition) appendix XD volatile oil determination method, can also adopt organic solvent extraction, supercritical CO Extraction and other existing technologies to extract, or obtain by purchasing commercially available products.

[0023] Prove the beneficial effect of the present invention below by concrete pharmacodynamics test.

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Abstract

The invention provides an application of amomum tsao-ko oil in preparing a medicine for treating methicillin-resistant staphylococcus aureus infectious disease. The invention also provides an application of conjunctive use of the amomum tsao-ko oil with beta-lactam antibiotics in preparing a medicine for treating the methicillin-resistant staphylococcus aureus infectious disease. The amomum tsao-ko oil provided by the invention has obvious MRSA resistant activity in vitro and MRSA infection resistant curative effect in vivo, and can enhance the MRSA resistant activity of the beta-lactam antibiotics in vitro, thereby showing that the amomum tsao-ko oil not only has the development and application prospects as a singly used anti-infective new drug, but also has the development and application prospects as a traditional Chinese medicine new drug conjunctively used with the beta-lactam antibiotics to restore the MRSA resistant activity thereof and reverse multiple drug-resistant activities of MRSA.

Description

technical field [0001] The invention relates to the use of grass fruit oil in the preparation of medicines for treating infections caused by methicillin-resistant Staphylococcus aureus, which belongs to the field of medicines. Background technique [0002] Staphylococcus aureus is a clinically common and highly toxic bacterium. Since the advent of penicillin in the 1940s, infectious diseases caused by Staphylococcus aureus have been largely controlled, but with the widespread use of penicillin, some golden yellow Staphylococci produce penicillinase, which can hydrolyze the β-lactam ring, showing resistance to penicillin. Scientists have developed a new semi-synthetic penicillin that is resistant to penicillinase, namely methicillin. After it was applied clinically in 1959, it has effectively controlled the infection of Staphylococcus aureus enzyme-producing strains. Since Jevons first discovered methicillin-resistant Staphylococcus aureus (MRSA) in the UK in 1961, MRSA has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P31/04A61K31/43A61K31/545A61K31/546
CPCA61K31/43A61K31/545A61K31/546A61K36/9064A61K2236/37A61K2300/00
Inventor 代敏彭成孙丰慧龙娜娜李建龙林琳
Owner CHENGDU MEDICAL COLLEGE
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