Composition containing rhizoma atractylodis macrocephalae polysaccharides and rhizoma atractylodis stearin and preparation method and application of composition

A technology of Atractylodes atractylodes polysaccharide and atractylodes stearin, which is applied in the pharmaceutical composition of Atractylodes atractylodes atractylodes, containing Atractylodes atractylodes polysaccharides, can solve the problem of no synergistic anti-peptic ulcer effect of the composition, and achieve good synergistic effect and good curative effect

Inactive Publication Date: 2017-09-12
苏州半部堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, in the prior art, there is no report on the preparation of a pharmaceutical composition by mixing Atractylodes macrocephala polysaccharides and Atractylodes stearin, and there is no report that the composition can produce a synergistic anti-peptic ulcer effect

Method used

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  • Composition containing rhizoma atractylodis macrocephalae polysaccharides and rhizoma atractylodis stearin and preparation method and application of composition
  • Composition containing rhizoma atractylodis macrocephalae polysaccharides and rhizoma atractylodis stearin and preparation method and application of composition
  • Composition containing rhizoma atractylodis macrocephalae polysaccharides and rhizoma atractylodis stearin and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 1000 g of dried rhizome of Atractylodes macrocephala Koidz from the Compositae plant, soak in 95% (V / V) ethanol to degrease, centrifuge to remove ethanol, extract twice with 12L water at 90°C, combine the water extracts, concentrate under reduced pressure to the total extract With a volume of 8 L, add 24 L of 95% (V / V) ethanol, let stand overnight at 4°C, and centrifuge to obtain a precipitate;

[0042] Dissolve the obtained precipitate with 3L of pure water, centrifuge to remove insoluble matter, adjust the pH of the supernatant to 2.8 with 2N HCl, let stand at 4°C for about 4 hours, centrifuge to remove the precipitate, adjust the pH to 9 with 2N NaOH, add 90mL of 30% HO 2 0 2 After stirring and decolorizing at 60°C for 1 hour, add 9L of 95% (V / V) ethanol, let stand at 4°C for 12 hours, centrifuge to obtain a precipitate, wash the obtained precipitate twice with 2L of 90% ethanol, and dry under reduced pressure at room temperature to obtain Atractylodes macroceph...

Embodiment 2

[0048] Atractylodes stearin extract prepared by steam distillation

[0049] Put 1kg of dry rhizome granules of Atractylodes atractylodis into the grinding bottle of the volatile oil extractor, continue distilling for 5 hours according to the method in the appendix of Chinese Pharmacopoeia, then stop heating, pour water after cooling, and collect the oil on the surface of the distillate, which is Atractylodes stearin extract .

Embodiment 3

[0051] Preparation of Atractylodes stearin extract by organic solvent extraction

[0052] Put 1 kg of dry rhizome particles of Atractylodes atractylodis into a flask, use n-hexane as solvent, extract under reflux for 8 hours, and distill off the solvent under reduced pressure to obtain Atractylodes stearin extract.

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Abstract

The invention relates to a composition containing rhizoma atractylodis macrocephalae polysaccharides and rhizoma atractylodis stearin and a preparation method and application of the composition. The composition comprises rhizoma atractylodis macrocephalae polysaccharide extract and rhizoma atractylodis stearin extract, wherein the rhizoma atractylodis macrocephalae polysaccharide extract is total polysaccharides extracted from the dry rhizomes of compositae rhizoma atractylodis macrocephalae, the saccharide component content in the rhizoma atractylodis macrocephalae polysaccharide extract is not less than 70% of the total amount of the extract, and polysaccharide weight-average molecular weight is not lower than 10kD; the rhizoma atractylodis stearin extract is total volatile oil extracted from the dry rhizomes of rhizoma atractylodis, and the content sum of atractylol and eudesmol in the rhizoma atractylodis stearin extract is not less than 50wt% of the total amount of the extract. The two components of the composition are coordinated to achieve a synergic effect so as to increase the curative effect of the composition on peptic ulcer.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition containing Atractylodes atractylodes polysaccharide and atractylodes stearin, a preparation method and application thereof. Background technique [0002] Atractylodes macrocephala is used as medicine with rhizomes and has many medicinal functions. The main functions are: invigorating the spleen and replenishing qi, drying dampness and promoting diuresis, antiperspirant, and preventing miscarriage. It is generally used for spleen deficiency, lack of food, abdominal distension and diarrhea, phlegm and retention, dizziness and palpitations, edema, spontaneous sweating, and restless fetal movement. Tubaizhu strengthens the spleen, harmonizes the stomach and relieves miscarriage. [0003] The main function of Atractylodes Rhizoma Atractylodis is to invigorate the spleen, dry dampness, relieve stagnation, and ward off foulness. It is mainly used to tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A23L33/125A23L33/115A61P1/04A61K31/715
CPCA23L33/115A23L33/125A23V2002/00A61K31/715A61K36/284A61K2300/00A23V2200/32A23V2250/21A23V2250/18A23V2300/14
Inventor 纪旭
Owner 苏州半部堂生物科技有限公司
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