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A kind of vascular stent and preparation method thereof

A vascular stent and element technology, applied in the medical field, can solve problems such as secondary damage to blood vessels, and achieve high accuracy.

Inactive Publication Date: 2020-12-01
SHENZHEN LIFE VALLEY SCI & TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Embodiments of the present invention provide a vascular stent and a preparation method thereof, aiming to solve the problem of necrotic damage to varying degrees around embolized or stenotic blood vessels due to blood supply problems before and during the placement of the vascular stent, causing secondary damage to the blood vessel , the need to repair vascular injury or promote angiogenesis at the site of ischemic injury

Method used

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  • A kind of vascular stent and preparation method thereof
  • A kind of vascular stent and preparation method thereof
  • A kind of vascular stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] In the embodiment of the present invention, copper chloride (CuCl 2 ) as the source of divalent copper element, polylactic acid-glycolic acid copolymer (PLGA) is used as an auxiliary material, and the molar ratio of copper chloride and polylactic acid-glycolic acid copolymer is 9:1, wherein the content of divalent copper element material The amount is 1.7 μmol, mix copper chloride and polylactic acid-glycolic acid copolymer and spray on the base of the stent, and then place the stent in 80ml of normal human plasma sample solution to determine the concentration of divalent copper ions, divalent The concentration of copper ions as figure 1 shown.

Embodiment 2

[0026] In the embodiment of the present invention, citric acid chelated copper is used as the source of divalent copper element, poly-DTH iminocarbonic acid, polyethylene terephthalate and poly-β-hydroxybutyrate are used as auxiliary materials, and citric acid chelated The ratio of the amount of copper substance to the sum of the amount of three auxiliary materials of poly DTH iminocarbonic acid, polyethylene terephthalate and poly β-hydroxybutyrate is 9:1, wherein, divalent copper element The amount of the substance is 1.9 μmol. After mixing copper citrate chelate with poly-DTH iminocarbonic acid, polyethylene terephthalate and poly-β-hydroxybutyrate, it is modified on the base of the vascular stent, and then the vascular stent Placed in 80ml of normal human plasma sample solution to determine the concentration of divalent copper ions, the concentration of divalent copper ions is as follows figure 2 shown.

Embodiment 3

[0028] In the embodiment of the present invention, copper chloride (CuCl 2 ) as a divalent copper element source, adopting polyfumaric acid as an auxiliary material, the amount ratio of cupric chloride and polyfumaric acid substance is 19:1, wherein, the amount of divalent copper element substance is 1.4 μ mol, and cupric chloride After mixing with polyfumaric acid, it is electroplated on the base of the vascular stent, and then the vascular stent is placed in 80ml of normal human plasma sample solution to measure the concentration of divalent copper ions. The concentration of divalent copper ions is as follows: image 3 shown.

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Abstract

A blood vessel stent and manufacturing method thereof. The blood vessel stent comprises: a blood vessel stent body, and a coating applied on the surface thereof. The coating comprises a copper(II). The blood vessel stent can promptly release copper(II) ions at a region of a blood vessel injured when placing the stent, thereby facilitating effective repair and regeneration of the blood vessel.

Description

technical field [0001] The invention relates to the medical field, in particular to a vascular stent and a preparation method thereof. Background technique [0002] With the changes in human diet structure and work habits, and the intensification of population aging, vascular diseases have become a huge problem for human beings. About 17 million people worldwide die of this disease every year. It is estimated that by 2020, cardiovascular and cerebrovascular diseases will The death toll from the disease will reach 25 million. [0003] Clinical medical research has found that the use of vascular stents can effectively treat cardiovascular and cerebrovascular diseases such as vascular stenosis and intraluminal obstruction. Since the invention of vascular stents widely used in coronary arteries in the 1980s, vascular stent technology has attracted more and more attention. The industrialization of vascular stent technology provides an effective solution for vascular patients. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/16
CPCA61L31/08A61L31/088A61L31/10A61L31/16A61L2300/102A61L2300/606C08L89/06C08L5/08C08L1/02C08L67/04
Inventor 张华利刘牧龙许文超
Owner SHENZHEN LIFE VALLEY SCI & TECH RES INST CO LTD