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Compositions and methods of using il-8 to increase milk production and improve reproductive health and inhibit hyperketosis in mammals

A mammal, milk production technology, applied in the direction of drug combination, dairy products, milk preparations, etc., can solve the problems of reproductive performance impact, elimination, and milk production reduction.

Active Publication Date: 2021-09-14
CORNELL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Postpartum uterine disorders (eg, metritis, endometritis, and retained placenta) are important for animal welfare, causing discomfort and culling of cows from the herd; they also lead to profoundly affected reproductive performance, reduced milk production, and treatment fee

Method used

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  • Compositions and methods of using il-8 to increase milk production and improve reproductive health and inhibit hyperketosis in mammals
  • Compositions and methods of using il-8 to increase milk production and improve reproductive health and inhibit hyperketosis in mammals
  • Compositions and methods of using il-8 to increase milk production and improve reproductive health and inhibit hyperketosis in mammals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] This example provides a description of the materials and methods used to generate the data described in Example 2.

[0071] Farm and Management

[0072] The study was conducted on a large commercial dairy farm in Cayoga County, near Ithaca, New York. The farm milks 3300 Holstein cows 3 times a day in a double 52 stall parallel parlor. Cows are housed in free-range barns with concrete stalls covered with mats and manure solids. All cows were fed a fully mixed ration consisting of approximately 55% forage (corn silage, semi-dry silage, and wheat straw) and 45% concentrate (corn meal, soybean meal, canola, cottonseed, and citrus pomace) (dry material basis) . Diets were formulated to meet or exceed the NRC nutritional requirements for lactating Holstein cows weighing 650 kg and producing 45 kg of 3.5% fat corrected milk (NRC, 2001). On-farm reproductive management using a combination of Presynch, Ovsynch, Resynch, and estrus detection, 25-30% of cows are fed through ...

Embodiment 2

[0090] This example presents the results obtained using the materials and methods described in Example 1.

[0091] Regarding the number of multiparous and primiparous animals enrolled, the number of enrolled animals with positive E. coli cultures in utero, the number of enrolled animals with placenta present at enrollment, the number of enrolled animals with Descriptive statistics for the number of enrolled animals with calves that were female, male, twin, or stillborn, mean gestational days at delivery, mean body condition score at delivery, and mean rectal temperature at enrollment are presented in Table 1.

[0092] Table 1: Descriptive statistics for the 213 study cows enrolled in the three treatment groups.

[0093]

[0094] figure 1 The effects of treatments on lactation week milk production in primiparous and multiparous cows are presented in . IL-8 treated cows had higher overall milk production; control, L-IL8 and H-IL8 cows were 33.1 kg / d (95% CI = 32.0-34.2), 3...

Embodiment 3

[0109] This example replicates the methods described in Examples 1 and 2 above, and further demonstrates that a wider range of rIL-8 dosages is effective in improving milk production and milk content. The study was also conducted on a commercial dairy farm in Cayoga, NY. A total of 341 new cows were enrolled in the study for 116 days. Within 12 hours of farrowing, cows were randomly assigned to receive an intrauterine infusion of 9.5 mg rIL-8 (high IL-8; n=86), 0.095 mg rIL-8 (medium IL-8; n=82), 0.0095 mg rIL8 (low IL8; n=88), or received no treatment (control; n=85). Postpartum cows are handled within 12 hours of farrowing. Cows were restrained in a head-fixed position and the perineal area was disinfected with ethanol (70% v / v). A sterile gold-plated artificial insemination catheter (Livestock Concepts Inc., Black Wadden, Iowa) attached to a 250 ml saline bag each containing each dose of rIL8 was introduced craniovaginally, maneuvered through the cervix, and the treatmen...

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Abstract

The present disclosure provides compositions and methods for improving the reproductive health of mammals and increasing milk production from female mammals. The method involves administering to a female mammal an effective amount of IL-8 such that the reproductive health of the mammal is improved, or the milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect, the present disclosure encompasses the prevention and / or treatment of uterine disorders by administering IL-8 to a female mammal.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Patent Application No. 62 / 099,643, filed January 5, 2015, the disclosure of which is incorporated herein by reference. [0003] field of invention [0004] The present disclosure generally relates to improving milk production and reproductive health in mammals by administering interleukin-8 (IL-8). Background technique [0005] As the world population grows and, more importantly, as per capita purchasing power parity increases, the demand for animal protein (milk, meat and eggs) will increase steadily and inevitably; to avoid inflationary pressures, animal The supply of protein products must increase significantly and sustainably, but at the same time minimize the expansion of agricultural land. Furthermore, feed efficiency has been reported to be the single largest contributor to changes in carbon footprint, and improving feed conversion efficiency can reduce greenhouse gas emis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/20A61P15/14A61P15/00A23K20/147A23K50/10
CPCA23V2002/00A23K20/147A23K50/10A61P3/00A61P15/14A61K38/2053A23V2250/542A23L33/00A61P43/00A23C9/14A61K38/20A23C9/20A23C2230/10A61K9/0034
Inventor R·C·比卡尔霍
Owner CORNELL UNIVERSITY
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