Anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and application of product

A technology of dehydrohaeline hydrochloride and Candida albicans, which is applied in the field of medicine, can solve the problems of high toxicity and side effects, achieve the effects of reducing toxicity and side effects, strong effect, and overcoming the problem of fungal drug resistance

Inactive Publication Date: 2017-12-29
QILU CHILDRENS HOSPITAL OF SHANDONG UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the above-mentioned prior art, the purpose of the invention is to provide a combination of dehydrohalamine hydrochloride in order to overcome the problem of relatively large toxic and side effects caused by the current fungal drug resistance and the high usage of dehydrohalamine hydrochloride. Antifungal products of fluconazole and their application

Method used

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  • Anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and application of product
  • Anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and application of product
  • Anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and application of product

Examples

Experimental program
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Embodiment 1

[0050] Example 1 Dehydrohaemaline hydrochloride and fluconazole joint antifungal action assay

[0051] 1. Materials

[0052] 1.1 Drugs and reagents

[0053] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0054] Ambroxol hydrochloride (HAR), Dalian Meilun Biotechnology Co., Ltd.;

[0055] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0056] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0057] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0058] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0059] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0060] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0061] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0062] Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0063] Potassium dihydrogen phosphate, Shanghai Xinbao Fine Chemical...

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Abstract

The invention discloses an anti-CA (candida albicans) product combining harmine hydrochloride and fluconazole and an application of the product and belongs to the technical field of medicines. The combined antifungal function of fluconazole and harmine hydrochloride on drug-resistant CA are researched with multiple methods. The effective concentration of fluconazole to harmine hydrochloride is 1:32 (mu g / mL, for CA3) or 1:16 (mu g / mL, for CA2) when fluconazole and harmine hydrochloride are combined to be applied, the minimum inhibitory concentration is 8 mu g / mL and 0.25 mu g / mL (for CA3) or 0.5 mu g / mL (for CA4). When harmine hydrochloride and fluconazole are combined, the antibacterial activity of fluconazole for drug-resistant CA can be enhanced, the coordinated antifungal action can be generated, the drug resistance of drug-resistant CA to fluconazole can be reversed, and a research direction is provided for development of new drugs and new application of old drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antifungal product of dehydrohamaline hydrochloride combined with fluconazole and its [0002] application. Background technique [0003] Candida albicans (Candida albicans, CA) is a common opportunistic pathogenic fungus, belonging to the yeast family Candida. Systemic fungal infections rarely occur in the case of normal human immune function, but in the past 30 years, due to the emergence of various predisposing factors such as immunosuppression, organ transplantation, acquired immunodeficiency syndrome, invasive candida infection (invasive Candidia infection, ICI) rate is on the rise, seriously threatening the lives of patients. Although ICI caused by various non-Candida albicans has increased, Candida albicans is still the most important pathogen causing ICI. Taking the results of a multi-center survey conducted in China in 2013 as an example, ICI caused by Candida alb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61K31/4196A61P31/10
CPCA61K31/4196A61K31/437A61K2300/00
Inventor 李秀云郝丽娜吴学新
Owner QILU CHILDRENS HOSPITAL OF SHANDONG UNIV
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