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Effervescent tablet containing alpha-ketoacid and preparation method of effervescent tablet

A technology of effervescent tablets and ketoacid, which is applied in the field of medicine, can solve problems such as single compatibility, single applicable population, and poor taste, and achieve the effects of simple process, uniform ingredients, and convenient operation

Active Publication Date: 2018-01-09
JING JING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the existing problems of effervescent tablets containing α-ketoacids in the prior art, the amino acid compatibility and α-ketoacid compatibility are single, resulting in poor taste and single applicable population, etc., the present invention provides an effervescent tablet containing α-ketoacids and its preparation method

Method used

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preparation example Construction

[0032] In one embodiment, the preparation method at least includes the following steps:

[0033] (1) After mixing the trehalose, α-keto acid, α-keto acid salt, L-glutamine, aminoacetic acid and zinc carnosine, wet granulation to obtain complex A;

[0034] (2) After mixing lysine, arginine and flavoring agent, wet granulation to obtain complex B;

[0035] (3) According to the same weight ratio, take part of complex A and complex B respectively, configure it into an aqueous solution, add an alkaline regulator to the aqueous solution, adjust the pH to 7.35-7.45, record the basic regulator and complex A, and The ratio of substance B;

[0036] (4) According to the proportioning in the step (3), the remaining complex A, the complex B and the alkaline regulator are mixed to obtain the mixed material;

[0037] (5) Evenly spray the binder whose weight is 2-7% of the total weight of the mixed material into the mixed material, and carry out tabletting treatment to obtain effervescent t...

Embodiment 1

[0048] The preparation method of the effervescent tablet containing α-keto acid, comprises the steps:

[0049](1) In the C-class area of ​​the clean room, the humidity is controlled to be ≤45%, and the temperature is controlled at 23-25°C. By weight, 4.0kg of trehalose, 2.0kg of α-ketoglutarate, and α-ketovaline are weighed. Calcium 7.5kg, α-hydroxymethionine 4.5kg, α-ketoleucine calcium 7.5kg, α-ketoisoleucine calcium 4.0kg, α-ketoacid calcium 3.0kg, α-ketophenylalanine calcium 3.0kg , L-glutamine 1.0kg, magnesium glycine 0.5kg, and carnosine zinc 0.5kg, a total of 11 substances were mixed uniformly in a double-cone mixer, and carried out aqueous phase wet granulation, passed through a granulator, and selected a 120μm sieve. Sieve and prepare α-ketoacid complex A for future use, with a total weight of 38.7kg;

[0050] (2) At the same time, in another mixer, 1.0kg of lysine, 1.0kg of arginine, and 1.5kg of pineapple essence and flavoring agent were subjected to wet granulatio...

Embodiment 2

[0054] The preparation method of the effervescent tablet containing α-keto acid, comprises the steps:

[0055] (1) In the C-class area of ​​the clean room, the humidity is controlled to be ≤45%, and the temperature is controlled at 23-25°C. By weight, 8.0kg of trehalose, 2.0kg of α-ketoglutarate, and α-ketovaline are weighed. Calcium 8.0kg, α-hydroxymethionine 5.5kg, α-ketoleucine calcium 6.5kg, α-ketoisoleucine calcium 5.5kg, α-ketoacid calcium 3.0kg, α-ketophenylalanine calcium 3.0kg , 1.0kg of L-glutamine, 1.0kg of magnesium glycine, and 0.5kg of zinc carnosine were mixed uniformly in a double-cone mixer, and carried out aqueous phase wet granulation, passed through a granulator, and sieved with a 120 μm sieve. Prepare α-ketoacid complex A for use, with a total weight of 45.0kg;

[0056] (2) At the same time, in another mixer, 1.0kg of lysine, 1.0kg of arginine, and 3.5kg of strawberry essence were wet-granulated, passed through a granulator and a 120 μm screen, and prepar...

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Abstract

The invention relates to the technical field of medicines, in particular discloses an effervescent tablet containing alpha-ketoacid and a preparation method of the effervescent tablet. The effervescent tablet containing the alpha-ketoacid is prepared from the following ingredients in parts by weight: 60-100 parts of alpha-ketoacid, 230-410 parts of alpha-ketoacid salt, 20-100 parts of trehalose, 10-60 parts of L-glutamine, 1-10 parts of amino magnesium acetate, 1-10 parts of carnosine zinc, 1-10 parts of lysine, 1-10 parts of arginine and 5-60 parts of a flavor agent. According to the effervescent tablet containing the alpha-ketoacid, which is provided by the invention, specific alpha-ketoacid, specific alpha-ketoacid salt and specific amino acid serve as main ingredients, various ingredients are compatible, the replenishment of energy and amino acid is effectively improved, the body fluid equilibrium is promoted, so that the effervescent tablet containing the alpha-ketoacid can be used as a health care product to relieve the symptoms of sub-healthy crowds such as psoas ache, weakness and dizziness, meanwhile, the trehalose and the flavor agent are added in the effervescent tabletcontaining the alpha-ketoacid, the mouthfeel of the effervescent tablet is improved, a user can rapidly get rid of a sub-healthy state, so that the effervescent tablet is conducive to recovering somatic functions.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an effervescent tablet containing α-keto acid and a preparation method thereof. Background technique [0002] An α-keto acid is a keto acid in which two carboxyl groups are directly adjacent, and pyruvate is the simplest α-keto acid. Pyruvate can be decomposed into acetaldehyde and carbon dioxide during alcoholic fermentation. It can also be decomposed into acetyl coenzyme A and sulfur dioxide under the action of enzymes. There is a similar reaction in the tricarboxylic acid cycle. Another typical reaction is the transamination reaction, in which an α-keto acid gains an amino group and a glutamic acid loses an amino group without releasing ammonia. Through this reaction pyruvate can be converted to alanine, oxaloacetate (which is both an alpha-keto acid and a beta-keto acid) to aspartate, and alpha-ketoglutarate to glutamate. The α-ketoacids generated after deamination of am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A23L33/125A23L33/175A23L33/16A23L33/18A61K9/46A61K47/26A61K38/05A61P29/00A61P25/00A61P39/00A61K33/30A61K31/194A61K31/198
Inventor 何连顺米造吉李斌水马静
Owner JING JING PHARMA
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