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Application of phellinus linteus polysaccharides in preparing medicine and health care food

A technology of health food and Phellinus polysaccharide, which is applied in the direction of drug combination, medical preparations containing active ingredients, food science, etc., can solve the problems of no public reports on therapeutic or preventive effects, and achieve enhanced insulin sensitivity, improved function, The effect of preventing insulin resistance

Inactive Publication Date: 2018-01-09
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Phellinus linteus (Phellinus linteus), mostly parasitic on dead standing trees of broad-leaved trees such as mulberry, is a traditional fungal traditional Chinese medicine. Phellinus polysaccharide (PLP) is its main drug active ingredient. Studies have shown that Phellinus polysaccharide has anti- Cancer, cancer prevention, pain relief, regulation of human immunity, and prevention and treatment of liver cirrhosis, liver ascites, etc., but there is no public report on the treatment or prevention of chronic metabolic diseases such as obesity, type Ⅱ diabetes, and fatty liver

Method used

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  • Application of phellinus linteus polysaccharides in preparing medicine and health care food
  • Application of phellinus linteus polysaccharides in preparing medicine and health care food
  • Application of phellinus linteus polysaccharides in preparing medicine and health care food

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Embodiment Construction

[0025] The following experiment combined with the use of Phellinus polysaccharides to intervene in obese mice induced by high-sugar and high-fat diets illustrates the effect of the application of Phellinus polysaccharides in pharmaceuticals.

[0026] Taking 60 male C57BL / 6 mice as the experimental subjects, they were divided into three groups, 20 mice in each group, and the feeding method of each group was as follows:

[0027] Group a (standard feed group): fed with standard feed for 16 weeks, wherein the mice were gavaged with normal saline in the last 4 weeks, twice a day, and the dose of gavage of normal saline was 10 mL / kg body weight;

[0028] Group b (high-sugar and high-fat feed group): fed with high-sugar and high-fat feed for 16 weeks, and in the last 4 weeks, the mice were administered with normal saline twice a day, and the dose of normal saline was 10 mL / kg body weight ;

[0029] Group c (high-sugar and high-fat feed + Phellinus polysaccharide group): fed with hig...

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Abstract

The invention discloses application of phellinus linteus polysaccharides in the field of the preparation of medicines and health care food. The product has the functions of lowering the levels of fasting blood-glucose and insulin, improving liver phospholipid balance and the one carbon unit metabolism of a human body and enhancing insulin sensitivity. The product can be used for treating or preventing chronic metabolic diseases including insulin resistance, hyperglycemia, hyperinsulinemia, type 2 diabetes, fatness, non-alcoholic fatty liver, high blood pressure, hyperlipidemia and the like.

Description

technical field [0001] The invention relates to the technical field of pharmacy and health food, in particular to the application of Phellinus polysaccharide in the preparation of medicine and health food. Background technique [0002] Insulin resistance is an important symptom of metabolic diseases. Insulin resistance refers to the decline in the efficiency of insulin in promoting glucose uptake and utilization due to external reasons, that is, the decline in insulin sensitivity, and the body compensatoryly secretes excessive insulin to produce hyperinsulinemia. Insulin resistance leads to impairment of glycogen synthesis ability in the liver. In order to maintain normal blood sugar, pancreatic β cells compensatoryly increase insulin secretion. Long-term high levels of pancreatic islets cause the liver to increase the lipid uptake from peripheral blood and the fatty acid synthesized by itself from scratch, resulting in fat Aggregation and the occurrence of fatty liver, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10A61P3/04A61P9/12A61P3/06A61P1/16A61P5/50A23L33/125
Inventor 王华林冯涵刘志国温万芬
Owner WUHAN POLYTECHNIC UNIVERSITY
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