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Promoting the expression of sarcoplasmic reticulum calcium pump to treat chronic heart failure Chinese medicine composition formula

A technology of chronic heart failure and sarcoplasmic reticulum, which is applied in the direction of medical formula, drug combination, plant raw materials, etc., can solve the problems of high morbidity and mortality, and achieve the effect of reliable curative effect, small dosage and convenient administration

Active Publication Date: 2020-07-03
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Despite continuous improvements in the prevention and treatment of CHF, its morbidity and mortality remain high

Method used

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  • Promoting the expression of sarcoplasmic reticulum calcium pump to treat chronic heart failure Chinese medicine composition formula
  • Promoting the expression of sarcoplasmic reticulum calcium pump to treat chronic heart failure Chinese medicine composition formula
  • Promoting the expression of sarcoplasmic reticulum calcium pump to treat chronic heart failure Chinese medicine composition formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh the following raw materials: Aconite 16g, Astragalus 10g, Curcuma 20g, Ophiopogon japonicus 8g;

[0035] Put each raw material drug in a closed container and decoct it twice. During the first decoction, use 6 times the weight of the raw material drug, heat it at 88°C for 32 minutes after boiling, and obtain the decoction of the first decoction after filtering. Boil liquid; when boiling for the second time, use 8 times the water volume of the raw material drug, heat it at 92°C for 18 minutes after boiling, and obtain the second decoction liquid after filtering; combine the two decoction liquids, filter, and combine filtrate. Concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and pulverize into fine powder (for example: pass through 80 mesh). Sterilize with Co60 (for example, irradiation dose 8k). Made into powder. Usage: 2 times a day, 7 days a week, 2 weeks as a course of treatment.

[0036] In order to verify the therapeut...

Embodiment 2

[0075] Weigh the following raw materials: Aconite 12g, Astragalus 40g, Curcuma 10g, Ophiopogon japonicus 20g;

[0076] Put each raw material drug in a closed container and decoct twice. During the first decoction, use 7 times the weight of the raw material drug. After boiling, keep it at 89°C for 31 minutes. After filtering, the decoction of the first decoction is obtained. Boil liquid; when boiling for the second time, use water 7 times the weight of the raw material drug, after boiling, keep warm at 91°C for 19 minutes, and obtain the second decoction liquid after filtering; combine the two decoction liquids, filter, and combine filtrate. Concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and then add appropriate amount of auxiliary materials to obtain tablets. Usage: 5 tablets each time, 2 times a day, 7 days a week, 2 weeks as a course of treatment.

[0077] In order to verify the therapeutic effect of the Chinese medicine composition...

Embodiment 3

[0108] Weigh the following raw materials: Aconite 16g, Astragalus 45g, Curcuma 5g, Ophiopogon japonicus 14g;

[0109] Put each raw material drug in a closed container and decoct twice. During the first decoction, use 8 times the weight of the raw material drug. After boiling, keep it at 90°C for 30 minutes, and filter to obtain the decoction of the first decoction. Boil liquid; when boiling for the second time, use 6 times the weight of the raw material drug, heat it at 90°C for 20 minutes after boiling, and obtain the second decoction liquid after filtering; combine the two decoction liquids, filter, and combine filtrate. Concentrate under reduced pressure, dry under reduced pressure to obtain dry extract, and then add appropriate amount of dextrin as auxiliary material to obtain granules. Usage: 2 times a day, 7 days a week, 2 weeks as a course of treatment.

[0110] In order to verify the therapeutic effect of the Chinese medicine composition formula or Chinese medicine p...

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Abstract

The invention discloses a traditional Chinese medicine composition formula for promoting sarcoplasmic reticulum calcium pump expression to treat chronic heart failure. The traditional Chinese medicinecomposition formula comprises the following raw medicinal materials: radix aconiti carmichaeli, astragalus membranaceus, rhizoma curcumae and radix ophiopogonis. In addition, the invention further discloses a traditional Chinese medicine composition formula for promoting sarcoplasmic reticulum calcium pump expression to treat chronic heart failure. The traditional Chinese medicine composition formula comprises the following raw medicinal materials: radix aconiti carmichaeli, astragalus membranaceus, rhizoma curcumae and radix ophiopogonis. Correspondingly, the invention further discloses a traditional Chinese medicine preparation for promoting the sarcoplasmic reticulum calcium pump expression to treat chronic heart failure. The traditional Chinese medicine preparation is prepared from the traditional Chinese medicine composition, and is at least one of water decoction, powder, tablets, granules or capsules. In addition, the invention discloses a preparation method of the traditionalChinese medicine preparation for promoting the sarcoplasmic reticulum calcium pump expression to treat chronic heart failure. Moreover, the invention further discloses application of the traditional Chinese medicine composition formula and application of the traditional Chinese medicine preparation. The traditional Chinese medicine composition formula is capable of effectively promoting the sarcoplasmic reticulum calcium pump expression to treat chronic heart failure (CHF).

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a formula of a Chinese medicine composition, a Chinese medicine preparation, a preparation method of the Chinese medicine preparation, an application of the Chinese medicine composition and an application of the Chinese medicine preparation. Background technique [0002] Chronic heart failure (CHF for short) is a complex clinical syndrome in which various heart structural or functional diseases lead to poor ventricular ejection and / or filling function, and it is the terminal stage of the development of various heart diseases. Since the 1990s, CHF has become the only cardiovascular disease whose morbidity, prevalence, hospitalization rate, mortality rate and medical expenses have all increased significantly, and this situation is still increasing. Due to the high prevalence rate, morbidity rate and deteriorating chronic disease course, the huge cost of long...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P9/04
Inventor 刘永明鲁成宋磊
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M