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Pharmaceutical composition for prevention and treatment of bronchial asthma

A technology for bronchial asthma and a composition is applied in the field of pharmaceutical compositions for preventing and treating bronchial asthma, and can solve problems such as drugs for asthma that have not yet been seen

Inactive Publication Date: 2018-01-16
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of drugs that can completely cure asthma

Method used

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  • Pharmaceutical composition for prevention and treatment of bronchial asthma
  • Pharmaceutical composition for prevention and treatment of bronchial asthma
  • Pharmaceutical composition for prevention and treatment of bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 prepares the pharmaceutical composition for preventing and treating bronchial asthma

[0026] According to the mass ratio of 2.5: 2.5: 1, take the herb, orris root and honey (the quality of the raw materials involved, the herb, orris root and honey, conform to the relevant regulations under the corresponding medicinal materials promulgated by the Chinese Pharmacopoeia 2010 edition), a total of 5kg, 95% Heat and reflux extraction with ethanol three times, use it successively for 3h, 3h, and 1h, filter, combine the filtrates, concentrate and recover ethanol, and evaporate the obtained concentrated solution to obtain ethanol extract; the extract is suspended in water, extracted with ethyl acetate, and the upper layer is separated , reclaiming the organic solvent to obtain part of the extract of ethyl acetate; the part of the extract of ethyl acetate was then eluted with 30%, 50%, and 70% ethanol to obtain 30%, 50%, and 70% ethanol elution parts; The extract is...

Embodiment 2

[0027] Embodiment 2: the influence of the medicinal composition of Herbal Herb, Orris Root and Honey on Bronchial Asthma

[0028] (1) Subjects: patients with chronic persistent asthma diagnosed as bronchial asthma by modern medicine, whose clinical control level is uncontrolled.

[0029] (2) Sample size: The number of cases in the treatment group and the control group is arranged in a ratio of 1:1, and the clinical curative effect of the treatment group is better than that of the control group. According to the formula for estimating the sample content of superiority clinical trials, according to the general requirements of curative effect and statistics , Control the rate of loss to follow-up below 15-20%, the observed number of qualified cases required by the treatment group and the control group is 110 cases, 220 cases in total.

[0030] (3) Blinding method: In order to better meet the requirements of evidence-based medicine and make the research results more reliable, a tw...

Embodiment 3

[0045] Example 3: Effects of Composition Extracts of Herbs, Orris Root and Honey on Bronchial Asthma

[0046] 60 female BALB / c mice aged 7 weeks in healthy and clean grade, with a body weight of 16-18 g (provided by Shanghai Xipuerbikai Experimental Animal Co., Ltd.), were randomly divided into 6 groups, 10 in each group, namely the normal control group ( NC), asthma model group (A), 30% alcohol washing group (30% alcohol-washing), 50% alcohol washing group (50% alcohol-washing), 70% alcohol washing group (70% alcohol-washing) and acetic acid Ethyl acetate extract group (ethyl acetate extract): From the 0th day, the mice were given a one-time intraperitoneal injection of 0.2ml of a saline suspension of 20ug ovalbumin and 2mg aluminum hydroxide, so that the mice were in a sensitized state. The sensitization was repeated three times in the same way on days 7, 14 and 21. From the 25th day, 3% ovalbumin was inhaled by ultrasonic atomization for about 30 minutes each time to induce...

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Abstract

Belonging to the field of traditional Chinese medicine, the invention relates to a pharmaceutical composition that is composed of Chinese herbal medicines Hyssopus officinalis, orris root, and honey or extracts thereof and is used for prevention and treatment of bronchial asthma. Multicenter, random and double-blind clinical study and observation of the pharmaceutical composition show that the pharmaceutical composition provided by the invention can effectively enhance the ACT score, improve lung function and increase the asymptomatic days of patients in nearly two weeks. Animal experiment results show that the pharmaceutical composition extract can reduce asthma mice's AHR, and lower the IL-5 and IL-13 level in BALF. The results show that the pharmaceutical composition has good therapeutic effect on bronchial asthma.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a pharmaceutical composition for preventing and treating bronchial asthma, in particular to a pharmaceutical composition for preventing and treating bronchial asthma, which is composed of Chinese medicinal materials, iris root and honey or their extracts. Background technique [0002] According to clinical research reports, bronchial asthma (referred to as "asthma") is a chronic airway allergic inflammatory disease involving a variety of cells, cytokines and their components, with airway inflammation, reversible airflow limitation, Pathological features such as airway mucus hypersecretion and airway remodeling. According to the statistics of the World Health Organization, there are currently about 300 million people worldwide suffering from asthma, which has become one of the most common chronic diseases in the world, and has become a major health problem and a major ch...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P11/06A61K35/644
Inventor 董竞成魏颖吕玉宝买买提江.阿布都瓦克居来提.托合提罗清莉陈美霞买买提.努尔艾合提
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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