49 results about "Double blinded" patented technology

A method and system are described for centrally managing data in an adaptive clinical trial or other adaptive process that is conducted at a plurality of geographically remote sites. The invention includes (1) flexible means for collecting data from remote sites; (2) processing, tracking, and validating such data and meta-data at a processing location; (3) interacting between central and remote sites to manage and resolve data discrepancies (4) reporting data to managers and remote sites; and (5) facilitation of special services to clinical research such as flexible randomization of patients, patient participation eligibility verification and double-blind trials. The invention is of particular relevance to adaptive clinical trials and other applications that demand the ability to quickly collect, process, and respond to various forms of data in order to adjust actions such as randomization schedules, interim analyses, treatment arm pruning, editing subpopulations, and other adaptive measures.

A server and a client mutually exclusively execute server-side and client-side commutative cryptographic processes and server-side and client-side commutative permutation processes. The server has access to a hash table, while the client does not. The server and client perform a method including: encrypting and reordering the hash table using the server; communicating the encrypted and reordered hash table to the client; further encrypting and further reordering the hash table using the client; communicating the further encrypted and further reordered hash table back to the server; and partially decrypting and partially undoing the reordering using the server to generate a double-blind hash table. To read an entry, the client hashes and permute an index key and communicates same to the server which retrieves an item from the double-blind hash table using the hashed and permuted index key and sends it back to the client which decrypts the retrieved item.

The present invention relates to pharmaceutical kits and methods to treat lung inflammation and redox imbalance in human cystic fibrosis patients using pharmaceutical compositions containing N-acetylcysteine (NAC), pharmaceutically acceptable salts of N-acetylcysteine, or N-acetylcysteine derivatives. In phase I studies, treatment with oral NAC at a dose of from about 1800 mg/day to about 3000 mg/day for a period of 4 weeks produced significant positive effects, namely, it decreased absolute numbers of white blood cells and neutrophils in the sputum and produced concomitant decreases in sputum neutrophil elastase specific activity and sputum interleukin-8 levels, suggesting an amelioration of lung inflammation in the patients. These effects were associated with an increased total GSH level in whole blood as well increased staining for reduced GSH in blood neutrophils, both of which reflect an amelioration of the redox imbalance in the patients. In ongoing phase II studies, oral NAC at a dose of about 2700 mg/day administered in double-blind manner for 12 weeks showed excellent safety and significantly decreased white blood cells in sputum as compared to placebo.

The invention provides a new application of berberine in the treatment of metabolic syndrome. Large-sample polycentric and randomized double-blind prospective experiments reveal the effect of berberine on metabolism of glucose and lipid and clarify the interrelation and common changes of the metabolism of glucose and lipid before and after berberine treatment. The berberine is used as a broad spectrum antibiotic and clinical drug with high efficiency and low toxicity for a long time and can be taken chronically without obvious side effect. Results of researches indicate that the berberine can help sufferers of type II diabetes mellitus combined with blood lipid abnormality regulate disorder of saccharometabolism and lipid metabolism, lower insulin resistance, avoid central obesity and elevation of blood pressure, thereby showing the positive effect of the berberine on the treatment of metabolic syndrome. The invention provides the new clinical application of berberine in the treatment of metabolic syndrome for human for the first time, which establishes the importance of the new clinical application of traditional Chinese medicine in the treatment of metabolic syndrome and provides a new basis as well, thereby helping to promote the traditional medicine of China.

Fructose-1,6-diphosphate (FDP) is used to treat patients who are undergoing coronary artery bypass grafting (CABG) surgery. Before cardiopulmonary bypass begins, a liquid that contains FDP is intravenously infused in the patient, preferably for about 10 to 30 minutes, to allow the FDP to enter the heart and lung tissue while the heart is still beating. FDP can also be added to cardioplegia solution; in addition, FDP can be injected after bypass is terminated, but if post-bypass injection is used, steps should be taken to avoid excess lactic acid accumulation, which appears to increase the risk of atrial fibrillation. To prevent or control lactic acidosis, a buffering or alkalizing agent, such as sodium bicarbonate, or an agent which reduces lactic acid formation, such as dichloroacetate, can be used. In double-blinded trials, this use of FDP substantially reduced heart damage and improved overall outcomes, as shown by lower levels of creatine kinase in blood, improvements in pumping performance, reduced requirements for vasodilator and inotropic drugs, and shorter stays in intensive care units. Certain dosages also reduced the likelihood of atrial fibrillation; however, FDP at high dosages increased the likelihood of A-fib. FDP also helped reduce pulmonary vascular resistance (PVR); this is an important finding, since pulmonary hypertension following cardiopulmonary bypass is a very difficult and often intractable problem, and is a contributing factor in nearly all deaths following CPB surgery.

The invention relates to a technology for diagnosing a bladder cancer through a molecular biology detection means and particularly provides a method for detecting FGFR3 gene mutation to diagnose the bladder cancer and a kit. The technology comprises the step that exons 7, 10 and 15 of an FGFR3 gene are detected to determine whether mutations exist in the exons or not. A double-blind screen test shows that the positive bladder cancer detection rate of the kit is 91.18%, the false positive rate is 3.23%, and the technology has a good clinical application value.

The invention relates to a method for capturing the phthisic Proteome in biological samples by supporting the stroma with the bead and separating the bead from the samples by the magnetic separator without the centrifuged samples. Then conduct the protein fingerprinting by the analysis of mass spectrography. The reagent kit tests the sensibility and the specificity of the normal person with the tuberculosis by Double Blind Test, which are all 100percent, among which the deviant SAA A can be used as blood serum in vitro for testing the normal person, minor tuberculosis patient, recrudescent tuberculosis patient, severe tuberculosis patient and tuberculosis patient after effective treatment. The elevated deviant SAA A shows poor treatment effectiveness, severe tuberculosis and the recrudescent tuberculosis, thus being a protein fingerprinting group for early warning of the early detection on tuberculosis worsening and prediction on tuberculosis recrudescence. The method provided in the invention can be used as the reagent kit to distinguish the protein fingerprinting or mass spectrum mapping between the normal person and the tuberculosis patient. The method is correct, convenient and fast.

The invention relates to a double-blind privacy protection face retrieval method and system. The method comprises the following steps that: 1) a client end detects an image containing a suspected missing person or an image containing a real missing person to obtain a face image; 2) the client carries out feature extraction on the detected face image to obtain a face representation vector; 3) thatclient end encrypts the face image and the extracted face representation vector and upload the encrypted face image and the extracted face representation vector to the cloud server; The cloud server matches the face image information of the suspected missing person with the face image information of the real missing person in the encrypted domain by using the face representation vector, obtains the matching result, and decrypts the adult face image by the matching result; 4) The client end receives the face image decrypted according to the matching result from the cloud server, and confirms whether the face image is a real missing person. The invention has good privacy protection, high precision and processing speed, and can provide an effective recovery scheme for missing persons, especially missing children.

The invention provides a system and a method for detecting qualities of double-blind laboratory samples based on cloud computing. The system comprises mass sample input ends, an information system disposed on a cloud platform and mass laboratory ends, and the information system on the cloud platform comprises a sample receiving end, a sample repackage marking end and a sample sending end; the sample receiving end is used for receiving sample detection applications and the samples sent by a sample input end and code-marks the samples; the sample repackage marking end is used for receiving the code-marked samples and repackage-marks the samples; and the sample sending end sends the repackage-marked samples to detection laboratories, and the background of the system transmits sample quality detection reports to detection sending people at the sample input end.

The invention provides an automatic electric power material sample sealing system. The sample sealing system involves a cabinet body automatic conveying device, a label recognition system and a multi-axis machine grabbing device; the label recognition system comprises an image recognition system and a positioning system, the image recognition system is used for finding the characteristics of an image and capturing and recognizing outstanding features, then the effective information in the image is recognized, the specific height of a nameplate is judged through three-dimensional coordinate positioning of the positioning system, and an instruction is issued to a cooperative sample sealing robot for automatic sample sealing so as to realize automatic acquisition of position information of the nameplate and a two-dimensional code; a quantum cloud code anti-counterfeit blind sample label is attached to a to-be-sealed electric power material through the cooperative sample sealing robot; "double-blind-sample management" of sampling and detecting is carried out, all links of materials sample sealing are subjected to layer-by-layer decomposition, so that integration of automatic sampling, sample sealing and sample feeding of the materials is realized, the quality level of the materials is improved, the operation stability of electric power facilities is ensured, the quality monitoring and sampling inspection work of the materials is reinforced.

The invention provides a wehicle survey information processing method and a system thereof. When a road accident occurs, it needs reporting, survey, rescue, loss determination, compensation and otherlinks, which may lead to the insured waiting time is too long, unreasonable quotation, and subsequent price disputes and other issues. The present application relates to an information processing system and an information processing method, wherein a server dispatches independently registered reconnaissance personnel to the site for reconnaissance, thereby alleviating the pressure of insufficientreconnaissance personnel of an insurance company and speeding up the reconnaissance process. At the same time, through the double blind quotation of surveyor and repair shop, it can effectively reducethe price dispute of vehicle damage, and ensure the objectivity of compensation.

Belonging to the field of traditional Chinese medicine, the invention relates to a pharmaceutical composition that is composed of Chinese herbal medicines Hyssopus officinalis, orris root, and honey or extracts thereof and is used for prevention and treatment of bronchial asthma. Multicenter, random and double-blind clinical study and observation of the pharmaceutical composition show that the pharmaceutical composition provided by the invention can effectively enhance the ACT score, improve lung function and increase the asymptomatic days of patients in nearly two weeks. Animal experiment results show that the pharmaceutical composition extract can reduce asthma mice's AHR, and lower the IL-5 and IL-13 level in BALF. The results show that the pharmaceutical composition has good therapeutic effect on bronchial asthma.

Epidermal growth factor (EGF) produced by an excretory recombinant approach was tested for its efficacy in treating various skin wounds. In a randomized double blind controlled study, local cream samples prepared with human EGF at a final concentration of as low as 0.02% (g/g) in topically suitable carrier were found to have an enhancing effect on the recovery of diabetes foot ulcers. This promotional effect is statistically significant and has resulted in a reduced mean healing time of over 3 weeks when compared with that of control. Both the 0.02% (g/g) and 0.04% (g/g) human EGF supplemented samples in comparison with control showed a trend of stimulatory effect when a recovery of 50% of an ulcer was considered. The EGF samples were also shown to be highly effective in promoting treatments of wounds resulting from bedsores and surgeries.

The various embodiments provide methods and systems for anonymously processing medical studies within a diagnostic healthcare environment. The embodiment methods and systems may provide efficient means for providing expert professionals with medical, legal, or other studies for review, without revealing client-identifying information. The embodiment methods and systems may further provide a means for obtaining professional expert opinion about case evidence from a number of experts all at the same time. The experts may be anonymous with reference to the requesting user (e.g., an attorney) and thus may be shielded from subpoena or further inquiry. The experts may also be free of biases as they would be unaware of the context and associations of the professional case review. Thus, the systems and methods of the various embodiments may provide a double-blind analysis of case evidence such as medical studies.

The invention relates to the field of food, in particular to a kit and an application thereof as well as a detection method. According to the invention, a method for detecting live cronobacter sakazakii in infant formula milk powder by using an EMA fluorescent quantitative PCR technology; a sample of infant formula milk powder polluted by cronobacter sakazakii is subjected to double-blind detection and simulation, and the tests for the removal rate of dead bacteria DNA, sensitivity and specificity indicate that the method is feasible. According to the method, EMA is used for the pretreatment of the detected sample, so as to avoid the false positive rate caused by dead bacteria or residual DNA in conventional PCR amplification and greatly improve the specificity. Moreover, the fluorescent PCR amplification technology of TaqMan-MGB probe is adopted, so as to greatly improve the bacterial sensitivity and specificity.

The invention relates to an acupuncture placebo needle device, belonging to the technical field of structures of placebo needles for the acupuncture clinical tests. The acupuncture placebo needle device is provided with a needle tube 1, a filiform needle 2, a filler 3, a base 4, a viscous rubber gasket 5 and sterile cotton 6, and is characterized in that the filiform needle is arranged in a semi-closed channel formed by connecting the base and the needle tube, the opening at the lower end of the base is completely closed, so that the filiform needle can not contact with the skin, and in the falling process of the filiform needle, the filler in the base can stimulate the hand feeling of a doctor; the needle body can be fixed in the base through the filler, and has the appearance nearly the same as that of a real acupuncture device for the acupuncture clinical tests. With the acupuncture placebo needle device, the acupuncture double-blind controlled test can be easily operated and realized.

The invention provides a multifunctional drying device. Heating power transmission and heat and moisture exchanging are performed in bidirectional air supplying and hot air circulating modes; the shortcoming that drying of the traditional drying room is carried out in an upward air supplying mode or a downward air supplying mode generally is overcome; double cold air inlet doors, double circulating fans and double blind windows are arranged on two sides of a drying chamber; the drying chamber is communicated with heat supply equipment through a pipeline; and two sides of the heat supply equipment are respectively connected with a positive-pressure combustion fan and a negative-pressure combustion fan. The shortcoming that the drying of the traditional drying room is carried out in the upward air supplying mode or the downward air supplying mode generally is overcome; and the problems that subsidiary agricultural products in the existing drying room are heated unevenly, heat loss is high and work efficiency is low are solved. Compared with the traditional drying room in China, the multifunctional drying device has the advantages that charging density is high, the labor and fuel are saved, the temperature and the humidity are stable, the automation degree is high, the multifunctional drying device is easy to operate, and the drying time is shortened. The multifunctional drying deice has wide applicability.

The invention discloses novel peptidase for preventing sow propagation, and a preparation technology, using method and application of the peptidase. The novel peptidase for preventing sow propagationconsists of the following components in percentage by weight of 50-65% of peptidase, 10-20% of subtilin, 10-20% of soybean isoflavone, 2-8% of catalase and the balance a carrier. 0.1% of the novel peptidase is added for feeding, after one period, the propagation and metabolism obstacle of the sows can be relieved, involuntary muscle of wombs is regulated, the anxiety degree of the sows at the prenatal period is reduced, and the childbirth time is shortened to 3 hours or less. The peptidas is used for activating the metabolism of protein and fat, the synthesis and metabolism capacity of liver can be accelerated, and improvement of milking capacity can be promoted. The ovarian function is regulated, the melting time of corpus luteum of the sows after weaning is controlled to 2-3 days or shorter, and many double blind experiment conforms that the effective rate is 93.3-96.9%.