Feed gas filling method for <13>C-urea synthesis
A filling method and raw material gas technology, applied in chemical instruments and methods, preparation of organic compounds, preparation of urea derivatives, etc., can solve problems such as large-scale preparation technology and process difficulties
Active Publication Date: 2018-02-06
SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD
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Problems solved by technology
13 C-urea is produced 13 C is an essential raw material for breath test reagents, and its large-scale preparation technology and process are still difficult
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[0019] Embodiments of the present invention will be specifically described below in conjunction with the accompanying drawings.
[0020] 13 The main components of the breath detection reagent used in the C breath test are 13 C-urea, that is, use 13 C marks the carbon element in urea, also known as carbon【 13 C]-urea【 13 CO(NH 2 ) 2 】 or Carbon【 13 C]-urea, which carries 13 C is 12 isotopes of C. If there is Helicobacter pylori (Hp) in the patient's stomach, the urease produced by it will decompose urea into 13 CO 2 , check the patient's exhaled gas with supporting equipment 13 The amount of C can be used to diagnose Helicobacter pylori (Hp) infection. contain 13 C labeled carbon【 13 C]-The large-scale preparation technology and process of urea has always been an industrial difficulty. The present invention is based on the method of Franz R.A. and Applegath F. to carry out carbon [ 13 C]-urea preparation, basic principle sees Organic Chemistry (1961), the 26th v...
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The invention relates to a feed gas filling method for <13>C-urea synthesis. The feed gas filling method comprises steps as follows: S100, purging of a reaction kettle: the reaction kettle is communicated with a helium source, and air in the reaction kettle is discharged completely by helium; S200, filling at ultralow temperature: the reaction kettle is communicated with a feed gas cylinder, and output pressure of the feed gas cylinder is higher than pressure in the reaction kettle; the reaction kettle is cooled by liquid nitrogen, the temperature in the reaction kettle is in a range from subzero 160 DEG C to subzero 200 DEG C, and pressure is in a range from-14 psig to -10 psig. According to the feed gas filling method for the <13>C-urea synthesis, all that is required is to communicate the reaction kettle with the feed gas cylinder and cool the reaction kettle, the gas filling process can be continuously and automatically completed by the aid of pressure difference between the reaction kettle and the feed gas cylinder and the ultralow temperature in the reaction kettle, so that <13>C and NH3 can enter the reaction kettle through fast filling without leakage.
Description
technical field [0001] The present invention relates to chemical synthesis method, more specifically, relates to a kind of 13 C- Feed gas filling method for urea synthesis. Background technique [0002] Helicobacter pylori (Hp for short) is a unipolar, multi-flagellate, blunt-rounded, spirally curved bacterium that was discovered in 1982 by Barry J. Marshall and Robin Warren ( J. Robin Warren first discovered it, and the two won the 2005 Nobel Prize in Physiology or Medicine. Subsequent studies have confirmed that this bacterium can indeed cause gastritis, chronic gastroenteritis, gastric ulcer, duodenal ulcer, non-ulcer dyspepsia and some gastric cancers. Therefore, Helicobacter pylori has attracted the attention of the medical community. The relationship between disease and disease has become a hot and difficult point in the research of global gastrointestinal disease infection for more than 30 years. [0003] At present, the methods for checking and identifying Helicob...
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IPC IPC(8): C07C273/02
CPCC07C273/02
Inventor 沈桂富范国民黄晋杰章高发闫长斌黄晓静王春玲
Owner SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD