Oil-in-water type Febantel nanoemulsion and method for preparing same

A Tiernano, oil-in-water type technology, applied in medical preparations of non-active ingredients, oil/fat/wax non-effective ingredients, pharmaceutical formulations, etc., can solve incomplete absorption, short half-life, and low bioavailability and other problems, to achieve the effect of stable drug effect, convenient taking, and enhanced drug effect

Active Publication Date: 2018-02-09
HENAN SOAR VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are non-Bantyr anti-insect drugs on the market now, which are insoluble in water, incomplete absorption, low bioavailability, and short half-life in vivo

Method used

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  • Oil-in-water type Febantel nanoemulsion and method for preparing same
  • Oil-in-water type Febantel nanoemulsion and method for preparing same
  • Oil-in-water type Febantel nanoemulsion and method for preparing same

Examples

Experimental program
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Embodiment 1

[0022] Based on 100g of nanoemulsion, the prescription is: 7g of febantyre, 32g of surfactant, 4g of co-surfactant, 11g of oil, and the balance is water; wherein, the surfactant is EL40, and the co-surfactant is EL40. The agent is absolute ethanol, and the oil is fatty acid glyceride.

[0023] Preparation:

[0024] (1) According to the mass percentage composition, weigh out febantyre, surfactant, co-surfactant, oil, water, and reserve;

[0025] (2) First, dissolve the febantyre in the co-surfactant completely, then add the surfactant, stir evenly, then add the oil, stir and mix; finally add water dropwise, and keep stirring while dropping until it forms Uniform and transparent system, that is, oil-in-water febantyre nanoemulsion is obtained.

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Abstract

The invention belongs to the field of veterinary medicines, and particularly discloses oil-in-water type Febantel nanoemulsion and a method for preparing the same. The oil-in-water type Febantel nanoemulsion comprises, by weight, 1-20% of Febantel, 25-45% of surfactant, 0-20% of co-surfactant, 1-20% of oil and the balance water. The surfactant is EL40, the co-surfactant is absolute ethyl alcohol,and the oil is fatty glyceride. The oil-in-water type Febantel nanoemulsion and the method have the advantages that the oil-in-water type Febantel nanoemulsion is uniformly distributed and is low in surface tension, excellent in flowability and convenient to administer, and systems are transparent and are good in stability; the oil-in-water type Febantel nanoemulsion can be quickly swallowed by reticuloendothelial cells after being administrated, accordingly, effects of medicines can be quickly realized, constant blood concentration and pharmacological effects can be maintained, the bioavailability of the medicines can be improved, the efficacy can be enhanced, and the dosage and use frequencies of the medicines can be reduced.

Description

Technical field [0001] The invention belongs to the field of veterinary medicine, and specifically relates to an oil-in-water type Febantyre nanoemulsion and a preparation method thereof. Background technique [0002] Febentyl is a colorless powder. This product is soluble in acetone, chloroform, tetrahydrofuran and dichloromethane, but insoluble in water and ethanol. [0003] Febantyre is a benzimidazole precursor anthelmintic, which has been approved as an anthelmintic for various animals in the United States. Febantyl and Nitopramine are both benzimidazole prodrugs, which are transformed into fenbendazole (and its sulfoxide) and oxfendazole in the gastrointestinal tract to exert effective deworming effects. [0004] Febantyre is mostly marketed in the United States as a compound preparation. For example, products for dogs and cats are often combined with praziquantel to expand the scope of deworming. [0005] According to the metabolism studies of cattle and sheep, most drugs are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/27A61K47/44A61K47/10A61K47/14A61P33/10
CPCA61K9/1075A61K31/27A61K47/10A61K47/14A61K47/44
Inventor 孙江宏高贵超陈华花素静陈阳
Owner HENAN SOAR VETERINARY PHARMA
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