Dispersion/deagglomeration device for powder agglomerates prepared by a powder spray device
A technology for agglomerates and powder aerosols, which is applied in the field of dispersion/depolymerization devices for powder agglomerates in powder aerosol devices, can solve problems such as interfering with the effect of the dispersion process, achieve multiple collision opportunities, improve user experience, and increase rotation retention. effect of time
Active Publication Date: 2021-01-29
SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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Problems solved by technology
[0013] However, the disadvantage of this technical solution is that its dispersion depends solely on the centrifugal effect of the airflow on the fine powder agglomerates and the resulting collision between the agglomerates and the wall of the rotating chamber, and the gravity of the agglomerates will interfere with the dispersion process.
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Embodiment
[0103] Shown in table 1 is prior art and the in vitro deposition experiment (n=3) of the present invention, experiment is evaluated respectively with two medicines, and experiment average value is done statistical analysis, because FPF directly reflects the depolymerization dispersion of device Ability, the higher the value, the stronger the ability of disaggregation and dispersion. From the average FPF values of medicine 1 and medicine 2, it can be known that the dispersion / deaggregation ability of the present invention is not lower than that of the prior art when the design size of the tangential rotating chamber is smaller. The MMAD data of drug 1 and drug 2 in the two devices are close.
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The invention discloses a method for dispersing / depolymerizing powder agglomerates of a powder mist device preparation, which belongs to the field of drug delivery devices. When the powder inhalation device is used for drug inhalation, the cross section of the tangential rotating chamber is in a horizontal state; the horizontal section of the powder inlet channel and the tangential rotating chamber is set on the same plane; in the middle of the upper part of the tangential rotating chamber A preparation powder outlet is provided; the central axis of the preparation powder outlet is perpendicular to the plane where the horizontal centerline of the tangential rotating chamber is located; when the powder aerosol inhalation device is used for drug inhalation, the preparation powder outlet of the tangential rotating chamber is in an upward state; A bent dispersing channel is arranged at the preparation powder outlet of the tangential rotating chamber. It utilizes the re-collision of the preparation powder agglomerates against the inner wall of the bent dispersion channel, so that the preparation powder after being rotated and separated by the tangential rotating chamber can be more thoroughly dispersed / deaggregated, further ensuring the dispersion / deaggregation effect of the preparation powder. It can be widely used in the field of design and manufacture of powder mist drug delivery devices of various specifications.
Description
technical field [0001] The invention belongs to the field of devices for injecting media into the human body, and in particular relates to an inhalation drug delivery device for sending a specified dose of powder aerosol into the patient's lungs through the oral cavity along with the breathing air, and the powder of the preparation in the device A device for dispersing / deagglomerating agglomerates. Background technique [0002] Powder spray refers to micronized drugs or in the form of capsules, vesicles or multi-dose reservoirs with carriers, using a special powder spray inhalation device or drug delivery device (or called an inhalation drug delivery device, also known as an inhalation drug delivery device in the past. It is a dry powder inhalation device or a dry powder drug delivery device), which is a preparation form in which the patient actively inhales aerosolized drugs into the lungs. [0003] Inhalation powder spray relies on the patient's spontaneous breathing to m...
Claims
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IPC IPC(8): A61M15/00
CPCA61M2206/10A61M2210/1025A61M15/001
Inventor 谭中华陈岚衡瑞霖杜狄峥周晓堂
Owner SHANGHAI SINE YELLOW RIVER PHARMA CO LTD