Preparation powder cluster dispersion/depolymerization method of dry powder inhaler
A technology of agglomerates and powder aerosols, used in the field of preparation powder agglomerates for dispersion/depolymerization, and inhalation drug delivery devices, which can solve problems such as interfering with the effect of the dispersion process, achieve multiple collision opportunities, improve user experience, and increase rotation. The effect of residence time
Active Publication Date: 2018-02-23
SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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Problems solved by technology
[0013] However, the disadvantage of this technical solution is that its dispersion depends solely on the centrifugal effect of the airflow on the fine powder agglomerates and the resulting collision between the agglomerates and the wall of the rotating chamber, and the gravity of the agglomerates will interfere with the dispersion process.
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[0102] Shown in table 1 is prior art and the in vitro deposition experiment (n=3) of the present invention, experiment is evaluated respectively with two medicines, and experiment average value is done statistical analysis, because FPF directly reflects the depolymerization dispersion of device Ability, the higher the value, the stronger the ability of disaggregation and dispersion. From the average FPF values of medicine 1 and medicine 2, it can be known that the dispersion / deaggregation ability of the present invention is not lower than that of the prior art when the design size of the tangential rotating chamber is smaller. The MMAD data of drug 1 and drug 2 in the two devices are close.
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The invention discloses a preparation powder cluster dispersion / depolymerization method of a dry powder inhaler, and belongs to the field of medicine feeding instruments. When the dry powder inhaler is used for sucking medicine, the cross section of a tangential rotary cavity is maintained in a horizontal state; a powder inlet channel and a horizontal section of the tangential rotary cavity are arranged at the same plane; the middle of the upper portion of the tangential rotary cavity is provided with a preparation powder outlet; the central axis of the preparation powder outlet is perpendicular to the plane where the horizontal center axis of the tangential rotary cavity is located; when the dry powder inhaler is used for sucking the medicine, the preparation powder outlet of the tangential rotary cavity is maintained in an upward state; the preparation powder outlet of the tangential rotary cavity is provided with a section of bent dispersion channel. Secondary collision between thepreparation powder cluster and the inner wall of the bent dispersion channel is utilized to make the preparation powder dispersed / depolymerized more thoroughly after the powder is rotatably separatedby the tangential rotary cavity, and therefore the dispersion / depolymerization effect of the preparation powder is further ensured. The preparation powder cluster dispersion / depolymerization method ofthe dry powder inhaler can be widely applied in the design and manufacturing fields of powder inhalation feeding devices with different specifications.
Description
technical field [0001] The invention belongs to the field of devices for injecting media into the human body, and in particular relates to an inhalation drug delivery device for sending a specified dose of powder aerosol into the patient's lungs through the oral cavity along with the breathing air, and the powder of the preparation in the device Agglomerates are dispersed / deagglomerated. Background technique [0002] Powder spray refers to micronized drugs or in the form of capsules, vesicles or multi-dose reservoirs with carriers, using a special powder spray inhalation device or drug delivery device (or called an inhalation drug delivery device, also known as an inhalation drug delivery device in the past. It is a dry powder inhalation device or a dry powder drug delivery device), which is a preparation form in which the patient actively inhales aerosolized drugs into the lungs. [0003] Inhalation powder spray relies on the patient's spontaneous breathing to make the dru...
Claims
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IPC IPC(8): A61M15/00
CPCA61M2206/10A61M2210/1025A61M15/001
Inventor 谭中华陈岚衡瑞霖杜狄峥周晓堂
Owner SHANGHAI SINE YELLOW RIVER PHARMA CO LTD