Method for making model array of three-layer circular composite film

Abstract

The invention provides a method for making a model array of a three-layer circular composite membrane, comprising the following steps: 1) making a model whose apex angle cross-section is "U"-shaped and the fracture line cross-section is consistent, and the "U"-shaped model is combined into an array, and each The distance between the bottom of the "U" model is 3-5 mm; 2) Make a wet elastic layer, drug layer, and guide layer. The elastic layer is a dense degradable or non-degradable biofilm, and the drug layer is encapsulated to promote bone healing. The active drug sustained release system, the material of the guide layer is a degradable or non-degradable, absorbent or non-absorbable porous substance; 3) Cover the wet elastic layer on the model array, wrap the top corner of each model in the array and extend to the periphery of the model array, and then cover the wet drug layer on the elastic layer in the same range to form a biological microstructure membrane; 4) After the biological microstructure membrane is air-dried and fixed, place the biological Membrane shearing, peeling off the fabricated single biological microstructure membrane from the model.

Description

technical field [0001] The invention relates to a method for manufacturing a model array of a three-layer circular composite membrane. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line,...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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