Detection of cerebrospinal fluid

一种脑脊液、脊柱的技术，应用在检测生物样本中脑脊液（CSF）存在领域，能够解决花费3到5天等问题

Inactive Publication Date: 2018-03-27
NEUROLOGICAL SURGERY P C +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, to distinguish CSF from subcutaneous fluid, a fluid sample must be sent to a laboratory using electrophoresis, and results can take 3 to 5 days

Method used

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  • Detection of cerebrospinal fluid
  • Detection of cerebrospinal fluid
  • Detection of cerebrospinal fluid

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Embodiment Construction

[0033] Preferred embodiments of the present invention are described below.

[0034] Herein, unless stated otherwise, the singular is intended to include one or more. For example, "particle" includes one or more particles.

[0035] Transferrin (TF) is a secreted glycoprotein with various glycoforms including glycans blocked at their non-reducing ends with negatively charged sialic acid residues [11,12]. TF plays an important role in iron homeostasis and transport and in protecting the body from free radical damage associated with unbound iron [13]. TF in serum consists of 679 amino acid residues (~78kDa MW) and is separated by asparagine Asn 432 and Asn 630 There are two glycosylation sites on the TF glycoform, which are often occupied by N-linked glycans containing various terminal (non-reducing end) sialic acid (or N-acetylneuraminic acid) residues, resulting in TF glycoforms Heterogeneous populations [11,14] ( Figure 1A and 1B ). TF in serum consists only of fully sia...

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Abstract

The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 62 / 181,469, filed June 18, 2015, the contents of which are incorporated herein by reference in their entirety. Background technique [0003] Spinal fluid leakage resulting from incidental dural injury during spinal surgery is a relatively common complication, occurring in 2 to 17 percent of cases [1-6]. Often, a spinal fluid leak is discovered during surgery and successfully repaired. Occasionally, for example, if a small dural injury goes undetected during surgery or the initial repair is suboptimal, spinal fluid leakage can be delayed. Spine surgeons frequently encounter postoperative fluid effusions that may or may not represent a cerebrospinal fluid (CSF) leak. This problem is more common in lumbar spine surgery for degenerative disease. The diagnosis is easier to make if the patient presents with a positional headache or a clear leak. However, it is sometimes difficu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N33/566
CPCG01N2333/79G01N33/558G01N33/68G01N33/54326G01N2440/32G01N33/54306G01N33/54388
Inventor 权锡俊罗伯特·J·林哈特乔纳森·S·多迪克威廉·J·桑斯坦张福明
Owner NEUROLOGICAL SURGERY P C
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