Detection of cerebrospinal fluid

Abstract

The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 62 / 181,469, filed June 18, 2015, the contents of which are incorporated herein by reference in their entirety. Background technique [0003] Spinal fluid leakage resulting from incidental dural injury during spinal surgery is a relatively common complication, occurring in 2 to 17 percent of cases [1-6]. Often, a spinal fluid leak is discovered during surgery and successfully repaired. Occasionally, for example, if a small dural injury goes undetected during surgery or the initial repair is suboptimal, spinal fluid leakage can be delayed. Spine surgeons frequently encounter postoperative fluid effusions that may or may not represent a cerebrospinal fluid (CSF) leak. This problem is more common in lumbar spine surgery for degenerative disease. The diagnosis is easier to make if the patient presents with a positional headache or a clear leak. However, it is sometimes difficu...

AI Technical Summary

Problems solved by technology

Currently, to distinguish CSF from subcutaneous fluid, a fluid sample must be sent to a laboratory using electrophoresis, and results can take 3 to 5 days

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