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Probiotic composition, preparation, bacterial sludge and application

A probiotic preparation and probiotic technology, applied in the field of medical biology, can solve problems such as unhealthy teeth and achieve the effect of promoting oral immune function

Inactive Publication Date: 2018-04-03
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of probiotic composition, this probiotic composition is beneficial to the regeneration of damaged alveolar bone, can inhibit the growth of periodontal pathogenic bacteria at the same time, can prevent and treat periodontitis to a certain extent. Effectively inhibit periodontal disease and solve the problem of unhealthy teeth in modern people

Method used

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  • Probiotic composition, preparation, bacterial sludge and application
  • Probiotic composition, preparation, bacterial sludge and application
  • Probiotic composition, preparation, bacterial sludge and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Lactobacillus acidophilus is 4 x 10 8 CFU, Streptococcus salivarius M18 is 4 x 10 8 CFU, Streptococcus salivarius K12 is 2 x 10 8 CFU.

Embodiment 2

[0027] Lactobacillus acidophilus is 1 x 10 8 CFU, Streptococcus salivarius M18 is 1 x 10 8 CFU, Streptococcus salivarius K12 is 8 x 10 8 CFU.

[0028] A probiotic preparation can be made from the probiotic composition of Examples 1-2 and a pharmaceutically acceptable carrier. The unit of the probiotic composition in embodiment 1-2 is not limited to 10 8 CFU, at 10 7 CFU~10 10 CFU.

[0029] For example, one is implemented as a probiotic gel, and the other is implemented as a probiotic buccal tablet.

[0030] In order to further illustrate the beneficial effect of the present invention, the inventor has deliberately done several groups of comparative experiments. The comparison content is as follows:

[0031] The following comparative examples were used as comparison groups.

Embodiment 5

[0065] Embodiment 5 probiotic gel

[0066] A kind of preparation method of probiotic gel is characterized in that comprising the following steps:

[0067] (1) Preparation of probiotic bacteria slime: take probiotic strains in BHI liquid medium, 5% CO 2 1. Under the condition of 37°C, cultivate in an anaerobic environment for 12 hours, centrifuge the probiotic culture solution at a speed of 3000r / min for 10min, and wash it repeatedly with normal saline to obtain the probiotic slime.

[0068] (2) Gel matrix: the gel matrix is ​​made up of polymer gel material, bioadhesive material, humectant, distilled water, and described polymer material is carbomer, poloxamer, hydroxypropyl cellulose, One or more of hydroxypropyl methylcellulose sodium and chitosan; the bioadhesive material is one or more of sodium hyaluronate, hydroxypropyl methylcellulose and sodium alginate species; the humectant is one or more of glycerin, propylene glycol polyethylene glycol, glycerol, and sorbitol.

...

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Abstract

The invention discloses probiotic composition. The probiotic composition comprises Lactobacillus acidophilus, streptococcus salivarius M18 and streptococcus salivarius K12. By means of the probiotic composition, regeneration of damaged alveolar bone is facilitated, growth of periodontal pathogens can be inhibited, periodontitis can be prevented and treated to a certain degree, periodontal diseasescan be inhibited effectively, and the problem of unhealthy teeth of modern people is solved.

Description

technical field [0001] The invention relates to the field of medical biology, in particular to a probiotic composition, preparation, bacteria slime and application. Background technique [0002] Medically, the soft tissue that surrounds and covers the teeth is called gingiva, and the acute and chronic inflammation that occurs in the gingival tissue is called gingivitis. Manifested as gum bleeding, redness, swelling, pain, continue to develop invasion of hard tissue, resulting in periodontitis, including inflammation of gum tissue and systemic diseases in the gums. [0003] Periodontal disease refers to diseases that occur in the tooth supporting tissue (periodontal tissue), including gingival disease involving only gingival tissue and periodontitis involving deep periodontal tissue (periodontal ligament, alveolar bone, cementum). category. Periodontal disease is a common oral disease, one of the main causes of adult tooth loss, and a major oral disease that endangers human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P1/02A61P31/02A61P31/04A61K35/744
CPCA61K35/744A61K35/747A61K2300/00
Inventor 杜俊蓉胡英杨雪琴黎慧谈增薛丽
Owner SICHUAN UNIV
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