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Climbazole alternative template molecularly imprinted polymer as well as preparation method and application thereof

A technology that replaces templates and molecular imprinting, applied in ion exchange, ion exchange regeneration, chemical/physical processes, etc., can solve the problems of template leakage and inaccuracy, and achieve the effect of efficient detection and ultra-high specific selectivity

Active Publication Date: 2018-04-03
LISHUI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material has better selectivity than imprinted polymers prepared with Campanol as a template, and solves the problem of inaccurate results caused by template leakage

Method used

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  • Climbazole alternative template molecularly imprinted polymer as well as preparation method and application thereof
  • Climbazole alternative template molecularly imprinted polymer as well as preparation method and application thereof
  • Climbazole alternative template molecularly imprinted polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Dissolve 1 mmol of the surrogate template molecule miconazole into acetonitrile (5.6 mL) containing 4 mmol of the functional monomer methacrylic acid, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in an ice bath, put the pre-polymerization solution in an ice bath and mix it with ultrasound for 10-15 minutes, then pass nitrogen gas for 10 minutes to remove the oxygen in the system, seal it and refrigerate it at 4°C for 2 hours, then place it at 60°C for 24 hours. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled with acetone to obtain a polymer with a particle size of 30-60 μm. The obtained polymer was sequentially subjected to Soxhlet extraction using methanol acetic acid (9:1, v / v) and methanol as extraction solvents to remove template molecules and other interfering substances, and the obtained polymer was dried overnight in a v...

Embodiment 2

[0044] Dissolve 1 mmol of the surrogate template molecule ketoconazole into acetonitrile (5.6 mL) containing 4 mmol of the functional monomer methacrylic acid, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in an ice bath, put the pre-polymerization solution in an ice bath and mix it with ultrasound for 10-15 minutes, then pass nitrogen gas for 10 minutes to remove the oxygen in the system, seal it and refrigerate it at 4°C for 2 hours, then place it at 60°C for 24 hours. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled with acetone to obtain a polymer with a particle size of 30-60 μm. The obtained polymer was sequentially subjected to Soxhlet extraction using methanol acetic acid (9:1, v / v) and methanol as extraction solvents to remove template molecules and other interfering substances, and the obtained polymer was dried overnight in ...

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Abstract

The invention discloses a climbazole alternative template molecularly imprinted polymer as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving an alternative template molecule, a cross-linking agent, a functional monomer and an initiator into a pore-forming solvent to obtain a prepolymerized solution, and carrying out polymerization reaction at the temperature of 55 to 75DEG C for 24 to 48 hours; grinding, sieving and precipitating a white block polymer generated by the polymerization reaction to obtain polymer white particleswith the particle size of 30 to 60mu m; carrying out Soxhlet extraction on obtained polymer particles by sequentially adopting methanol / acetic acid and methanol as extracting solvents and removing thealternative template molecule and unreacted substances to obtain the alternative template molecularly imprinted polymer. The alternative template molecularly imprinted polymer provided by the invention can be used as a solid phase extraction material, is applied to enrichment and purification of climbazole in environmental samples, food and personal caring products, has the advantages of high selectivity, high adsorption capacity and no template leakage, and has important significance for human health and environmental monitoring.

Description

technical field [0001] The invention relates to a highly selective enrichment and purification campanolin antifungal substitute template molecularly imprinted polymer and its preparation and application, belonging to the fields of environmental monitoring and new materials. Background technique [0002] Campanile, an azole fungicide, is widely used in various products containing antifungal active ingredients, especially in pharmaceuticals and personal care products, such as shampoo, skin cream, soap, toothpaste, body wash, etc. As a second-generation antifungal agent, the annual output of Campanola is gradually increasing (Environment International, 84(2015) 142). In recent years, it has been found that it has become a new type of pollutant, which poses potential hazards to the environment, organisms and humans. Reproductive toxicity (Journal of Hazardous Materials, 318 (2016) 794). For example, in 2013, Richter et al. found that the EC50 (lethal concentration) of Campolin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/26B01D15/08
CPCB01D15/08C08F222/1006C08F222/102C08J9/26C08J2335/02C08F220/06
Inventor 孙晓丽徐佳蒙唐林超杨罗星王慕华
Owner LISHUI UNIV
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